HDAC1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line.

expression correlates with a poor prognosis in patients with adenocarcinoma of the lung

X-radiation and siRNA inhibit expression of HDAC1 and HDAC2, weaken the inhibitory effect of HDAC on Axin, upregulate Axin expression and induce apoptosis of lung cancer cells

Involvement of SNIP1 in progression of lung cancer by regulating the RB/HDAC1 interaction.

novel HDAC1/4/miR-200b/E2F3 signaling contributes to chemoresistance of human lung adenocarcinoma cells

Overexpression of histone deacetylase 1 was associated with lung adenocarcinoma.

Gefitinib-resistant lung cancer cells show HDAC1 overexpression, and its knockdown sensitizes resistant cells to gefitinib.

DW22 antitumor agent upregulates RXRa and downregulates histone deacetylase in lung cancer and breast cancer tissues and cell lines

Meta-analysis results suggest that HDAC1 mRNA or protein expression may serve as a good diagnostic and prognostic marker for lung cancer.

Reptin directly interacted with histone deacetylase 1 (HDAC1) as the critical mechanism driving non-small cell lung cancer (NSCLC) tumour progression. Pharmacological disruption of the Reptin/HDAC1 complex resulted in a substantial decrease in NSCLC cell proliferation and induced significant sensitisation to cisplatin.

Results showed that the higher expression of HDAC1 in advanced stage of lung cancer regulates its downstream protein in its pathway through epigenetic regulation. The epigenetic regulation of uPAR by HDAC1 significantly affects the p38 MAPK activation pathway as tumor progress.