glycogen synthase kinase 3alpha/beta (GSK3alpha/beta) modulates tumor necrosis factor-a (TNF) induced increased lung vascular permeability

Zi Shen Decoction Inhibits Growth and Metastasis of lung cancer via Regulating the AKT/GSK-3beta/beta-Catenin pathway.

Phosphorylated-GSK3beta-ser9 and EGFR are involved in the histogenesis of different lung carcinomas.

role of GSK3beta in Pdcd4 expression lung cancer cells

The AKT/GSK-3beta signaling pathway is activated in lung cancer cells following inhibition of mTORC1.

CRISPR-Cas9n-mediated knockout and reconstitution studies establish that dynamin-1 is activated by Akt/GSK3beta signaling in H1299 non-small lung cancer cells.

Inhibition of p90 ribosomal S6 kinase attenuates cell migration and proliferation of the human lung adenocarcinoma through phospho-GSK-3beta and osteopontin.

Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta in non-small cell lung cancer cells.

our findings identify the miR-410/Gsk3beta/beta-catenin signaling axis is a novel molecular circuit in inducing stemness of non-small cells lung cancer

Oncogenic miR-19a and miR-19b were up-regulated in lung cancer stem cells which modulated cancer cells activity. miR-19 activated Wnt/beta-catenin pathway via directly targeting Glycogen Synthase Kinase 3 beta. Sulforaphane suppressed lung cancer stem cells through down-regulating miR-19 and inhibiting Wnt/beta-catenin pathway activation.

Using integrated analysis of genome-wide short hairpin RNA (shRNA) screening data in combination with genome-wide gene expression data, the study identified GSK3 as one of the key factors in p53-mediated apoptosis in human lung cancer cells.

GSK-3beta expression is associated with non-small cell lung cancer differentiation and GSK-3beta inhibits autophagy and enhances the radiosensitivity of non-small cell lung cancer cells

LINC00222 acts as a tumor suppressor in lung adenocarcinoma, regulating GSK3beta activity to promote tumor cell apoptosis.

Data suggested that miR-1246 could directly target the 3'-UTR of GSK-3B mRNA, the effect may be as an upstream target of beta-catenin in regulating cell activities of lung cancer.

GSK3beta interacted with PCNA in H1299 lung adenocarcinoma cells. Overexpression of PCNA protein decreased GSK3beta Ser9 phosphorylation. Downregulation of PCNA sensitized H1299 cells to LiCl-induced apoptosis.

PRMT5 Promotes Human lung cancer Cell Apoptosis via Akt/Gsk3beta Signaling Induced by Resveratrol.