mRNA transcripts are expressed in tumor cells of patients with small cell lung cancer

Increased gastrin-releasing peptide (GRP) receptor expression in small cell lung cancer cells confers sensitivity to [Arg6,D-Trp7,9,NmePhe8]-substance P (6-11)-induced growth inhibition

Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells

Bronchial gastrin-releasing peptide receptor expression was significantly associated with lung cancer in a multivariable logistic regression model adjusted for age, sex, smoking status and pulmonary function. lung cancer risk was not modified by sex.

GRPR expression was more pronounced in an advanced-stage lung cancer

Our results suggest that, similar to what happens in neutrophils, gastrin-releasing peptide is a migratory, rather than a proliferative, stimulus, for non-small cell lung carcinoma cells, indicating a putative role for gastrin-releasing peptide and gastrin-releasing peptide receptor in metastasis