lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2925
Symbol	GRPR
Synonymous	BB2
Full name	gastrin-releasing peptide receptor
Gene description	GRP-R\|GRP-preferring bombesin receptor\|bombesin receptor 2
Cytoband	Xp22.2
Gene type	protein-coding
Synonymous	MIM:305670; HGNC:HGNC:4609; HPRD:02376

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.820G>A; p.A274T; 23:16152310-16152310	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.820G>A; p.A274T; 23:16152310-16152310	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.820G>A; p.A274T; 23:16152310-16152310	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.120C>G; p.L40L; 23:16124073-16124073	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.121T>C; p.Y41H; 23:16124074-16124074	liver	carcinoma	Substitution - Missense
c.1101C>T; p.S367S; 23:16152591-16152591	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.121T>C; p.Y41H; 23:16124074-16124074	liver	carcinoma	Substitution - Missense
c.1000A>C; p.N334H; 23:16152490-16152490	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.111G>A; p.P37P; 23:16124064-16124064	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.651C>A; p.V217V; 23:16150542-16150542	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.891C>T; p.S297S; 23:16152381-16152381	skin	malignant_melanoma	Substitution - coding silent
c.841C>A; p.H281N; 23:16152331-16152331	central_nervous_system; brain	glioma	Substitution - Missense
c.80A>C; p.D27A; 23:16124033-16124033	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1035C>T; p.I345I; 23:16152525-16152525	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.959T>A; p.F320Y; 23:16152449-16152449	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.944C>T; p.S315F; 23:16152434-16152434	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.130C>T; p.P44S; 23:16124083-16124083	skin	malignant_melanoma	Substitution - Missense
c.944C>T; p.S315F; 23:16152434-16152434	skin	malignant_melanoma	Substitution - Missense
c.362T>C; p.L121P; 23:16124315-16124315	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.459C>A; p.A153A; 23:16150350-16150350	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.77C>T; p.A26V; 23:16124030-16124030	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.733C>T; p.P245S; 23:16150624-16150624	skin	malignant_melanoma	Substitution - Missense
c.733C>T; p.P245S; 23:16150624-16150624	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1122C>T; p.I374I; 23:16152612-16152612	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.314G>T; p.R105I; 23:16124267-16124267	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1102G>A; p.V368M; 23:16152592-16152592	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.457G>T; p.A153S; 23:16150348-16150348	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.275C>T; p.T92M; 23:16124228-16124228	central_nervous_system; brain	glioma	Substitution - Missense
c.616C>A; p.H206N; 23:16150507-16150507	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.672G>A; p.S224S; 23:16150563-16150563	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.218A>T; p.N73I; 23:16124171-16124171	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.662T>A; p.I221N; 23:16150553-16150553	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.186C>T; p.I62I; 23:16124139-16124139	skin	malignant_melanoma	Substitution - coding silent
c.1124A>G; p.N375S; 23:16152614-16152614	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.765G>A; p.Q255Q; 23:16150656-16150656	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.990G>A; p.R330R; 23:16152480-16152480	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.775C>T; p.R259W; 23:16152265-16152265	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1138C>A; p.H380N; 23:16152628-16152628	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.923G>A; p.R308H; 23:16152413-16152413	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1100C>G; p.S367C; 23:16152590-16152590	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1039C>A; p.R347R; 23:16152529-16152529	breast	carcinoma	Substitution - coding silent
c.672G>T; p.S224S; 23:16150563-16150563	lung	carcinoma; undifferentiated_carcinoma	Substitution - coding silent
c.819C>T; p.F273F; 23:16152309-16152309	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.819C>T; p.F273F; 23:16152309-16152309	pancreas	carcinoma	Substitution - coding silent
c.819C>T; p.F273F; 23:16152309-16152309	breast	carcinoma	Substitution - coding silent
c.528C>T; p.A176A; 23:16150419-16150419	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.543C>T; p.L181L; 23:16150434-16150434	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.528C>T; p.A176A; 23:16150419-16150419	pancreas	carcinoma	Substitution - coding silent
c.528C>T; p.A176A; 23:16150419-16150419	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.15C>A; p.D5E; 23:16123968-16123968	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.229C>T; p.L77L; 23:16124182-16124182	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.658G>A; p.V220I; 23:16150549-16150549	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.735C>A; p.P245P; 23:16150626-16150626	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1014C>A; p.L338L; 23:16152504-16152504	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.342A>C; p.K114N; 23:16124295-16124295	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.811G>T; p.G271C; 23:16152301-16152301	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.729T>A; p.N243K; 23:16150620-16150620	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.677T>A; p.I226N; 23:16150568-16150568	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.677T>A; p.I226N; 23:16150568-16150568	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.42C>A; p.D14E; 23:16123995-16123995	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.841C>T; p.H281Y; 23:16152331-16152331	skin	malignant_melanoma	Substitution - Missense
c.1144C>T; p.R382W; 23:16152634-16152634	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.458C>T; p.A153V; 23:16150349-16150349	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.529G>A; p.V177M; 23:16150420-16150420	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.395C>T; p.T132M; 23:16124348-16124348	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.107A>C; p.H36P; 23:16124060-16124060	breast	carcinoma	Substitution - Missense
c.1066A>G; p.T356A; 23:16152556-16152556	skin	malignant_melanoma	Substitution - Missense
c.619C>A; p.P207T; 23:16150510-16150510	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.493_494TG>CT; p.W165L; 23:16150384-16150385	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.970C>G; p.L324V; 23:16152460-16152460	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.25C>G; p.L9V; 23:16123978-16123978	breast	carcinoma	Substitution - Missense
c.632C>A; p.S211Y; 23:16150523-16150523	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.773C>T; p.S258F; 23:16152263-16152263	skin	malignant_melanoma	Substitution - Missense
c.90G>A; p.V30V; 23:16124043-16124043	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.235A>G; p.I79V; 23:16124188-16124188	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.731T>A; p.L244H; 23:16150622-16150622	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1144C>A; p.R382R; 23:16152634-16152634	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.193T>G; p.F65V; 23:16124146-16124146	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.84C>G; p.L28L; 23:16124037-16124037	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.803T>A; p.V268E; 23:16152293-16152293	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1137T>C; p.C379C; 23:16152627-16152627	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.705A>G; p.K235K; 23:16150596-16150596	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.575C>A; p.T192N; 23:16150466-16150466	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.663T>C; p.I221I; 23:16150554-16150554	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1108A>C; p.T370P; 23:16152598-16152598	breast	carcinoma	Substitution - Missense
c.944C>A; p.S315Y; 23:16152434-16152434	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.781C>A; p.R261R; 23:16152271-16152271	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.898C>T; p.H300Y; 23:16152388-16152388	skin	malignant_melanoma	Substitution - Missense
c.576C>A; p.T192T; 23:16150467-16150467	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.591C>T; p.A197A; 23:16150482-16150482	skin	malignant_melanoma	Substitution - coding silent
c.264C>T; p.L88L; 23:16124217-16124217	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.453T>C; p.S151S; 23:16150344-16150344	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.736G>A; p.V246M; 23:16150627-16150627	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.143G>A; p.G48E; 23:16124096-16124096	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.734C>G; p.P245R; 23:16150625-16150625	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.151A>G; p.I51V; 23:16124104-16124104	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1033A>G; p.I345V; 23:16152523-16152523	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1100C>A; p.S367Y; 23:16152590-16152590	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.977G>T; p.S326I; 23:16152467-16152467	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.574A>G; p.T192A; 23:16150465-16150465	central_nervous_system; brain	glioma	Substitution - Missense
c.446A>G; p.Q149R; 23:16150337-16150337	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.612G>A; p.E204E; 23:16150503-16150503	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.495G>A; p.W165*; 23:16150386-16150386	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.812G>A; p.G271D; 23:16152302-16152302	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1147T>C; p.Y383H; 23:16152637-16152637	stomach	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation