Links to all GeneRIF Items | 29110 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 30912981 (Tbk1) | Coculture of 2 mammary carcinoma cell lines, Ep5 from mice and MCF10A(MII) from humans, with isolated platelets induced morphologic as well as molecular changes characteristic of EMT, which was paralleled with activation of TBK1.TBK1 depletion using siRNA impaired platelet-induced EMT in Ep5 cells. TBK1 loss in mammary carcinoma cells during in vitro preconditioning with platelets suppressed lung metastases. |
| 23836654 (TBK1) | results collectively revealed TBK1 as a mitosis regulator through activation of PLK1 and also suggested metadherin as a putative TBK1 downstream effector involved in lung cancer cell survival |
| 28716898 (TBK1) | High TBK1 expression is associated with lung cancer. |