Malignant lung tumors (squamous cell carcinoma and adenocarcinoma) had significantly increased levels of this enzyme.

associations between several smoking variables and alcohol intake and lung cancer risk among GPX1(TT) carriers than among GPX1(CC) and GPX1(CT) carriers

Role for selenium in risk of lung cancer and independent regulation of GPX1 in a tumor cell line.

T-Allel of GPX1(Pro200Leu)plays a protective role in early onset lung cancer susceptibility

our findings indicate that PRDX6 promotes lung tumor growth via increased glutathione peroxidase and iPLA2 activities

Our findings suggested that overexpression of GPX1 is a novel molecular mechanism for cisplatin-based chemoresistance in Non-Small-Cell lung Carcinoma(NSCLC). GPX1 overexpression blocks cisplatin-induced ROS intracellular accumulation, activates PI3K-AKT pathway by increased AKT phosphorylation, and further leads to cisplatin resistance in NSCLC cells.