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Cancer metastasis database

Annotation category 5

Literatures

Literature evidence

Links to all GeneRIF Items

28514

PubMed (Gene Name)

Literature evidence

23769341 (DLL1)

Data suggest that overexpression of Delta-Like1 (DLL1) in small cell lung cancer may increase the sensitivity of cells to chemotherapeutic agents.

30940183 (Dll1)

Mice with CD11c lineage-specific deletion of Notch ligand gene Dll1, but not Jag2, exhibited accelerated growth of lung and pancreatic tumors concomitant with decreased antigen-specific CD8+T-cell functions and effector-memory (Tem) differentiation. Increased IL-4 but decreased IFN-gamma production and elevated populations of T-regulatory and myeloid-derived suppressor cells were observed in Dll1-ablated mice.