lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	28514
Symbol	DLL1
Synonymous	DELTA1\|DL1\|Delta
Full name	delta-like 1 (Drosophila)
Gene description	H-Delta-1\|delta-like protein 1\|drosophila Delta homolog 1
Cytoband	6q27
Gene type	protein-coding
Synonymous	MIM:606582; HGNC:HGNC:2908; Ensembl:ENSG00000198719; HPRD:05957; Vega:OTTHUMG00000016078

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1541C>A; p.P514H; 6:170283738-170283738	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1541C>A; p.P514H; 6:170283738-170283738	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1892G>A; p.G631D; 6:170283387-170283387	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.371T>C; p.I124T; 6:170288770-170288770	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1390G>A; p.D464N; 6:170283889-170283889	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1821C>T; p.I607I; 6:170283458-170283458	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1821C>T; p.I607I; 6:170283458-170283458	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.577C>T; p.R193C; 6:170288332-170288332	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1101C>A; p.A367A; 6:170285067-170285067	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1335C>T; p.D445D; 6:170283944-170283944	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2075C>T; p.P692L; 6:170283079-170283079	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.799A>T; p.T267S; 6:170285632-170285632	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.531C>T; p.F177F; 6:170288378-170288378	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.531C>T; p.F177F; 6:170288378-170288378	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.17C>A; p.A6E; 6:170290123-170290123	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.531C>T; p.F177F; 6:170288378-170288378	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.531C>T; p.F177F; 6:170288378-170288378	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.887A>G; p.K296R; 6:170285399-170285399	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.1100C>T; p.A367V; 6:170285068-170285068	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.360C>G; p.F120L; 6:170288781-170288781	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.437G>A; p.R146H; 6:170288472-170288472	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1362C>T; p.N454N; 6:170283917-170283917	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1239C>A; p.P413P; 6:170284929-170284929	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.583delC; p.R195fs*95; 6:170288326-170288326	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.583delC; p.R195fs*95; 6:170288326-170288326	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.598G>T; p.G200C; 6:170288311-170288311	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1307C>T; p.S436L; 6:170283972-170283972	skin	malignant_melanoma	Substitution - Missense
c.1802A>T; p.D601V; 6:170283477-170283477	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1971G>A; p.A657A; 6:170283308-170283308	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.837C>T; p.G279G; 6:170285594-170285594	NS	NS	Substitution - coding silent
c.1039G>A; p.E347K; 6:170285129-170285129	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.782C>T; p.P261L; 6:170285649-170285649	skin	malignant_melanoma	Substitution - Missense
c.1829C>T; p.T610M; 6:170283450-170283450	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2082G>A; p.S694S; 6:170283072-170283072	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2151C>T; p.C717C; 6:170283003-170283003	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.917A>C; p.N306T; 6:170285369-170285369	thyroid	other; neoplasm	Substitution - Missense
c.1951G>T; p.D651Y; 6:170283328-170283328	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1614C>T; p.G538G; 6:170283665-170283665	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1484C>G; p.T495S; 6:170283795-170283795	breast	carcinoma	Substitution - Missense
c.2034G>A; p.P678P; 6:170283245-170283245	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1835T>C; p.I612T; 6:170283444-170283444	skin	malignant_melanoma	Substitution - Missense
c.1116C>T; p.D372D; 6:170285052-170285052	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2034G>A; p.P678P; 6:170283245-170283245	oesophagus	carcinoma	Substitution - coding silent
c.671C>T; p.P224L; 6:170286298-170286298	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.712G>C; p.D238H; 6:170286257-170286257	pancreas	carcinoma	Substitution - Missense
c.1831C>T; p.Q611*; 6:170283448-170283448	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.671C>T; p.P224L; 6:170286298-170286298	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1930G>A; p.V644M; 6:170283349-170283349	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.541G>A; p.E181K; 6:170288368-170288368	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2115G>T; p.Q705H; 6:170283039-170283039	NS	NS	Substitution - Missense
c.541G>A; p.E181K; 6:170288368-170288368	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.541G>A; p.E181K; 6:170288368-170288368	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.612T>C; p.C204C; 6:170288297-170288297	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.508G>A; p.D170N; 6:170288401-170288401	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1914G>A; p.A638A; 6:170283365-170283365	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - coding silent
c.620G>A; p.R207H; 6:170288289-170288289	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.578G>A; p.R193H; 6:170288331-170288331	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1768A>T; p.M590L; 6:170283511-170283511	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1031C>T; p.T344M; 6:170285255-170285255	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2035A>G; p.T679A; 6:170283244-170283244	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.2117C>T; p.S706L; 6:170283037-170283037	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.97G>A; p.V33I; 6:170289766-170289766	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.962C>A; p.T321K; 6:170285324-170285324	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1604A>G; p.K535R; 6:170283675-170283675	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1017C>T; p.N339N; 6:170285269-170285269	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1137T>G; p.G379G; 6:170285031-170285031	central_nervous_system; brain	glioma	Substitution - coding silent
c.1971G>T; p.A657A; 6:170283308-170283308	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1069G>A; p.G357S; 6:170285099-170285099	thyroid	carcinoma	Substitution - Missense
c.553G>A; p.G185R; 6:170288356-170288356	ovary	carcinoma	Substitution - Missense
c.553G>A; p.G185R; 6:170288356-170288356	ovary	carcinoma	Substitution - Missense
c.1593C>T; p.D531D; 6:170283686-170283686	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1112C>T; p.A371V; 6:170285056-170285056	pancreas	carcinoma	Substitution - Missense
c.1367G>T; p.G456V; 6:170283912-170283912	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1830G>A; p.T610T; 6:170283449-170283449	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.614G>T; p.G205V; 6:170288295-170288295	thyroid	other; neoplasm	Substitution - Missense
c.1968C>A; p.D656E; 6:170283311-170283311	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1541C>T; p.P514L; 6:170283738-170283738	skin; neck	malignant_melanoma	Substitution - Missense
c.1755G>A; p.G585G; 6:170283524-170283524	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1133G>A; p.G378E; 6:170285035-170285035	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.1323C>T; p.D441D; 6:170283956-170283956	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - coding silent
c.1323C>T; p.D441D; 6:170283956-170283956	pancreas	carcinoma	Substitution - coding silent
c.1357G>A; p.A453T; 6:170283922-170283922	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.25C>T; p.L9L; 6:170290115-170290115	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.894C>A; p.C298*; 6:170285392-170285392	eye; uveal_tract	malignant_melanoma; spindle	Substitution - Nonsense
c.25C>T; p.L9L; 6:170290115-170290115	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.377C>A; p.A126D; 6:170288764-170288764	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1792C>A; p.R598S; 6:170283487-170283487	breast	carcinoma	Substitution - Missense
c.1248T>C; p.N416N; 6:170284920-170284920	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.829C>T; p.Q277*; 6:170285602-170285602	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1935G>T; p.Q645H; 6:170283344-170283344	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1960G>A; p.V654I; 6:170283319-170283319	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.242G>T; p.S81I; 6:170289621-170289621	liver	carcinoma	Substitution - Missense
c.242G>T; p.S81I; 6:170289621-170289621	liver	carcinoma	Substitution - Missense
c.631G>C; p.V211L; 6:170288278-170288278	skin	malignant_melanoma	Substitution - Missense
c.594C>T; p.A198A; 6:170288315-170288315	pancreas	carcinoma	Substitution - coding silent
c.507G>A; p.T169T; 6:170288402-170288402	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1957G>A; p.A653T; 6:170283322-170283322	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2124C>T; p.Y708Y; 6:170283030-170283030	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.2124C>T; p.Y708Y; 6:170283030-170283030	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.405C>T; p.L135L; 6:170288736-170288736	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1929C>T; p.L643L; 6:170283350-170283350	breast	carcinoma	Substitution - coding silent
c.1929C>T; p.L643L; 6:170283350-170283350	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.2003A>C; p.Q668P; 6:170283276-170283276	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1929C>T; p.L643L; 6:170283350-170283350	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1580C>A; p.P527Q; 6:170283699-170283699	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1793G>A; p.R598H; 6:170283486-170283486	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1793G>A; p.R598H; 6:170283486-170283486	pancreas	carcinoma	Substitution - Missense
c.1793G>A; p.R598H; 6:170283486-170283486	breast	carcinoma	Substitution - Missense
c.991G>A; p.E331K; 6:170285295-170285295	soft_tissue; fibrous_tissue_and_uncertain_o	gastrointestinal_stromal_tumour	Substitution - Missense
c.540C>T; p.D180D; 6:170288369-170288369	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1836C>T; p.I612I; 6:170283443-170283443	skin	malignant_melanoma	Substitution - coding silent
c.469G>A; p.E157K; 6:170288440-170288440	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.953C>G; p.P318R; 6:170285333-170285333	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1583C>T; p.A528V; 6:170283696-170283696	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1538delG; p.G513fs*24; 6:170283741-170283741	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1927C>T; p.L643F; 6:170283352-170283352	oesophagus	carcinoma	Substitution - Missense
c.1854G>A; p.K618K; 6:170283425-170283425	skin	malignant_melanoma	Substitution - coding silent
c.1156G>A; p.D386N; 6:170285012-170285012	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.502C>T; p.R168C; 6:170288407-170288407	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1383C>T; p.G461G; 6:170283896-170283896	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.376G>A; p.A126T; 6:170288765-170288765	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1131C>T; p.N377N; 6:170285037-170285037	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1131C>T; p.N377N; 6:170285037-170285037	prostate	carcinoma	Substitution - coding silent
c.1242T>G; p.C414W; 6:170284926-170284926	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1118G>A; p.G373D; 6:170285050-170285050	skin	malignant_melanoma	Substitution - Missense
c.1583C>A; p.A528E; 6:170283696-170283696	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.769T>C; p.C257R; 6:170285662-170285662	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2167-3delC; p.?; 6:170282882-170282882	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1903C>T; p.R635C; 6:170283376-170283376	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1913C>T; p.A638V; 6:170283366-170283366	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1523C>T; p.A508V; 6:170283756-170283756	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1697T>C; p.V566A; 6:170283582-170283582	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1155C>T; p.P385P; 6:170285013-170285013	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2079C>T; p.D693D; 6:170283075-170283075	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.523T>C; p.Y175H; 6:170288386-170288386	pancreas	carcinoma	Substitution - Missense
c.2154C>T; p.V718V; 6:170283000-170283000	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1879G>A; p.A627T; 6:170283400-170283400	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1879G>A; p.A627T; 6:170283400-170283400	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.700C>T; p.H234Y; 6:170286269-170286269	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1522G>T; p.A508S; 6:170283757-170283757	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1951G>A; p.D651N; 6:170283328-170283328	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.845delG; p.G282fs*8; 6:170285586-170285586	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.845delG; p.G282fs*8; 6:170285586-170285586	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.845delG; p.G282fs*8; 6:170285586-170285586	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.887A>C; p.K296T; 6:170285399-170285399	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1573C>T; p.P525S; 6:170283706-170283706	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1803C>T; p.D601D; 6:170283476-170283476	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1017C>A; p.N339K; 6:170285269-170285269	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1968C>G; p.D656E; 6:170283311-170283311	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.461C>T; p.T154M; 6:170288448-170288448	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1035T>A; p.D345E; 6:170285133-170285133	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.178T>A; p.F60I; 6:170289685-170289685	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1741G>A; p.D581N; 6:170283538-170283538	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.2081C>T; p.S694L; 6:170283073-170283073	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2081C>T; p.S694L; 6:170283073-170283073	urinary_tract; bladder	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation