Links to all GeneRIF Items | 2744 |
PubMed (Gene Name) | Literature evidence |
|---|---|
| 22326218 (GLS) | Inhibition of Gls1 kills lung cancer cells that overexpress MYC and catabolize glutamine. |
| 26575584 (GLS) | Data suggest that glutaminase C (GAC) inhibition maybe a potential treatment strategy for acquired erlotinib-resistant non-small cell lung cancer (NSCLC). |
| 29515166 (GLS) | Phosphorylation is a crucial post-translational modification of GAC, which is responsible for the higher glutaminase activity in lung tumor tissues and cancer cells. This study identified the key Ser314 phosphorylation site on GAC that is regulated by the NF-kappaB-protein kinase C epsilon axis. |
| 32228887 (GLS) | NUDT21 suppresses the growth of small cell lung cancer by modulating GLS1 splicing. |