lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2744
Symbol	GLS
Synonymous	AAD20\|GAC\|GAM\|GLS1\|KGA
Full name	glutaminase
Gene description	K-glutaminase\|L-glutamine amidohydrolase\|glutaminase C\|glutaminase kidney isoform, mitochondrial\|glutaminase, phosphate-activated
Cytoband	2q32-q34
Gene type	protein-coding
Synonymous	MIM:138280; HGNC:HGNC:4331; Ensembl:ENSG00000115419; HPRD:00700; Vega:OTTHUMG00000132701

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.473A>C; p.K158T; 2:190895238-190895238	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.748A>C; p.I250L; 2:190901959-190901959	liver	carcinoma	Substitution - Missense
c.559C>T; p.Q187*; 2:190895679-190895679	breast	carcinoma	Substitution - Nonsense
c.246G>A; p.E82E; 2:190881330-190881330	ovary	other; neoplasm	Substitution - coding silent
c.1617A>T; p.K539N; 2:190931604-190931604	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1411C>T; p.Q471*; 2:190927468-190927468	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1348C>A; p.P450T; 2:190927405-190927405	liver	carcinoma	Substitution - Missense
c.1348C>A; p.P450T; 2:190927405-190927405	liver	carcinoma	Substitution - Missense
c.1802T>G; p.V601G; 2:190954767-190954767	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1862A>G; p.N621S; 2:190962838-190962838	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1758T>A; p.S586S; 2:190954629-190954629	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.413G>C; p.S138T; 2:190895178-190895178	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.698A>C; p.E233A; 2:190900656-190900656	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1159C>T; p.R387*; 2:190923945-190923945	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.489C>T; p.L163L; 2:190895609-190895609	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1344G>A; p.L448L; 2:190927401-190927401	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1560T>C; p.D520D; 2:190931547-190931547	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.456G>T; p.E152D; 2:190895221-190895221	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.456G>T; p.E152D; 2:190895221-190895221	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.969G>A; p.L323L; 2:190905157-190905157	cervix	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.873G>C; p.L291F; 2:190905061-190905061	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1853+2T>G; p.?; 2:190954820-190954820	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1372A>T; p.S458C; 2:190927429-190927429	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1756T>C; p.S586P; 2:190954627-190954627	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.994C>T; p.P332S; 2:190910277-190910277	skin	malignant_melanoma	Substitution - Missense
c.506G>A; p.R169Q; 2:190895626-190895626	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1016T>G; p.I339S; 2:190910299-190910299	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.914T>C; p.V305A; 2:190905102-190905102	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1423C>T; p.H475Y; 2:190927480-190927480	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1650+1G>A; p.?; 2:190931638-190931638	skin; neck	malignant_melanoma	Unknown
c.1192_1194delAAG; p.K399delK; 2:190923978-190923980	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1360C>T; p.R454*; 2:190927417-190927417	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1198-2A>G; p.?; 2:190924541-190924541	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Unknown
c.1628G>A; p.R543Q; 2:190931615-190931615	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.556C>T; p.L186F; 2:190895676-190895676	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.735G>A; p.K245K; 2:190900693-190900693	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.653A>C; p.K218T; 2:190900611-190900611	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1525G>T; p.G509C; 2:190930536-190930536	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1909A>G; p.K637E; 2:190962885-190962885	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1281C>T; p.A427A; 2:190927338-190927338	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.421G>T; p.D141Y; 2:190895186-190895186	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1669C>A; p.L557I; 2:190953583-190953583	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1669C>A; p.L557I; 2:190953583-190953583	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1263A>C; p.E421D; 2:190927320-190927320	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.843C>T; p.P281P; 2:190905031-190905031	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1662G>C; p.V554V; 2:190953576-190953576	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1545T>C; p.I515I; 2:190930556-190930556	liver	carcinoma	Substitution - coding silent
c.1545T>C; p.I515I; 2:190930556-190930556	liver	carcinoma	Substitution - coding silent
c.1901A>G; p.D634G; 2:190962877-190962877	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1901A>G; p.D634G; 2:190962877-190962877	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1980C>T; p.T660T; 2:190962956-190962956	breast	carcinoma	Substitution - coding silent
c.1404C>T; p.F468F; 2:190927461-190927461	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1339G>T; p.V447L; 2:190927396-190927396	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1339G>T; p.V447L; 2:190927396-190927396	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1789+6A>C; p.?; 2:190954666-190954666	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.603A>C; p.K201N; 2:190895723-190895723	breast	carcinoma	Substitution - Missense
c.1789+2T>C; p.?; 2:190954662-190954662	stomach	carcinoma; adenocarcinoma	Unknown
c.1130+1G>A; p.?; 2:190921204-190921204	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1415T>G; p.F472C; 2:190927472-190927472	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1139C>A; p.S380Y; 2:190923925-190923925	oesophagus	carcinoma	Substitution - Missense
c.1404C>G; p.F468L; 2:190927461-190927461	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.728G>A; p.G243E; 2:190900686-190900686	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.403C>G; p.L135V; 2:190895168-190895168	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.1610_1611insA; p.L540fs*2; 2:190931597-190931598	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1273G>A; p.E425K; 2:190927330-190927330	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1273G>A; p.E425K; 2:190927330-190927330	urinary_tract; bladder	carcinoma	Substitution - Missense
c.815G>T; p.R272M; 2:190902026-190902026	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1521G>T; p.K507N; 2:190930532-190930532	skin	malignant_melanoma	Substitution - Missense
c.1443A>T; p.K481N; 2:190930454-190930454	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.1708C>T; p.R570*; 2:190953622-190953622	skin	malignant_melanoma	Substitution - Nonsense
c.917A>T; p.H306L; 2:190905105-190905105	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1806T>C; p.V602V; 2:190954771-190954771	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1264G>A; p.V422M; 2:190927321-190927321	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.531G>A; p.E177E; 2:190895651-190895651	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1918C>T; p.Q640*; 2:190962894-190962894	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1025C>A; p.T342N; 2:190910308-190910308	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1791T>C; p.G597G; 2:190954756-190954756	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1561C>A; p.L521I; 2:190931548-190931548	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1791T>C; p.G597G; 2:190954756-190954756	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1757C>G; p.S586C; 2:190954628-190954628	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1758T>C; p.S586S; 2:190954629-190954629	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.510G>A; p.T170T; 2:190895630-190895630	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1482T>A; p.N494K; 2:190930493-190930493	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1547A>G; p.H516R; 2:190930558-190930558	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.594T>C; p.D198D; 2:190895714-190895714	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1656G>T; p.K552N; 2:190953570-190953570	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1341A>T; p.V447V; 2:190927398-190927398	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1341A>T; p.V447V; 2:190927398-190927398	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1835A>G; p.N612S; 2:190954800-190954800	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1958A>G; p.D653G; 2:190962934-190962934	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1435C>T; p.P479S; 2:190930446-190930446	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation