lung cancer gene and literature database Home
Cancer metastasis database

Annotation category 5

Literatures

Literature evidence

Links to all GeneRIF Items

23035

PubMed (Gene Name)

Literature evidence

23856247 (PHLPP2)

Low PHLPP2 expression is associated with malignant phenotypes in non-small cell lung cancer.

25977341 (PHLPP2)

Our studies not only first time identify PHLPP2 downregulation by lung carcinogen B[a]P/B[a]PDE, but also elucidate a novel molecular mechanisms underlying lung inflammation and carcinogenesis upon B[a]P/B[a]PDE exposure.

31571378 (PHLPP2)

Results found PHLPP2 expression level frequently downregulated in non-small cell lung cancer (NSCLC) patients and associated with the presence of lymph node metastasis. Importantly, PHLPP2 was found to be an independent indicator of prognosis for overall and disease-free survival suggesting it as a robust clinical marker for NSCLC survival.