induction in tumoral stroma, but not in tumor cells, may promote angiogenesis in adenocarcinoma of the lung; may be important prognostic factor in adenocarcinoma of the lung

overexpression of thymidine phosphorylase is associated with invasiveness and metastasis in lung adenocarcinoma

the relationship between the expression of TK1 and TP as they relate to proliferation (Ki-67 labeling index) and angiogenesis (Chalkley count of CD31-stained blood vessels) in a series of 110 non-small-cell lung cancer (NSCLC) tumors

Thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase play a role in the prognosis of non-small-cell lung cancer.

action of thymidine phosphorylase in non-small cell lung cancer: crosstalk with Nrf2 and HO-1

These results indicated that hDHFR is not the only target of Pyr. We further found that thymidine phosphorylase (TP), an enzyme that is closely associated with the EMT of cancer cells, is also a target protein of Pyr. The data retrieved from the cancer Genome Atlas (TCGA) database revealed that TP overexpression is associated with poor prognosis of patients with lung cancer