levels of CAR expression observed in cases of squamous cell carcinoma lung cancers, and in cases of small cell lung cancers, and in adenocarcinoma lung cancers

These data suggest that if the mesenchymal cell phenotype is an accurate measure of an undifferentiated and invasive state, then CAR expression may be more closely aligned with this phenotype of lung cancer cells.

CAR expression in tumor tissues was significantly higher than that in normal lung tissues. CAR expression had a correlation with the histological grade of lung squamous cell carcinoma.

present work shows that stable and transient expression of CAR in tumor cells reduced lung metastasis in an experimental lung metastasis model; CAR expression likely acts as a metastatic suppressor