lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1525
Symbol	CXADR
Synonymous	CAR\|CAR4/6\|HCAR
Full name	coxsackie virus and adenovirus receptor
Gene description	46 kD coxsackievirus and adenovirus receptor (CAR) protein\|CVB3-binding protein\|HCVADR\|coxsackievirus B-adenovirus receptor\|coxsackievirus and adenovirus receptor
Cytoband	21q21.1
Gene type	protein-coding
Synonymous	MIM:602621; HGNC:HGNC:2559; Ensembl:ENSG00000154639; HPRD:11804; Vega:OTTHUMG00000074508

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.686T>C; p.V229A; 21:17560816-17560816	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.42delG; p.D15fs*6; 21:17513171-17513171	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Deletion - Frameshift
c.1049C>T; p.A350V; 21:17565643-17565643	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.374C>T; p.A125V; 21:17551912-17551912	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.123C>A; p.C41*; 21:17547106-17547106	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.340G>C; p.D114H; 21:17551878-17551878	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.831C>T; p.I277I; 21:17561474-17561474	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.685G>A; p.V229I; 21:17560815-17560815	pancreas	carcinoma	Substitution - Missense
c.44-1G>T; p.?; 21:17547026-17547026	breast	carcinoma	Unknown
c.148C>A; p.Q50K; 21:17547131-17547131	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.606C>T; p.A202A; 21:17560736-17560736	skin	malignant_melanoma	Substitution - coding silent
c.344T>C; p.I115T; 21:17551882-17551882	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.248A>G; p.Y83C; 21:17551786-17551786	liver	carcinoma	Substitution - Missense
c.386C>A; p.A129E; 21:17551924-17551924	ovary	other; neoplasm	Substitution - Missense
c.289G>T; p.D97Y; 21:17551827-17551827	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.500G>C; p.G167A; 21:17559060-17559060	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.422C>T; p.P141L; 21:17558982-17558982	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.344T>A; p.I115N; 21:17551882-17551882	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.597delA; p.N201fs*27; 21:17560727-17560727	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.597delA; p.N201fs*27; 21:17560727-17560727	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.830T>C; p.I277T; 21:17561473-17561473	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.830T>C; p.I277T; 21:17561473-17561473	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.211-1G>T; p.?; 21:17551748-17551748	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.935G>A; p.G312E; 21:17565529-17565529	skin	malignant_melanoma	Substitution - Missense
c.862A>G; p.T288A; 21:17565456-17565456	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.211-1G>T; p.?; 21:17551748-17551748	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.822T>A; p.H274Q; 21:17561465-17561465	skin	malignant_melanoma	Substitution - Missense
c.172C>T; p.L58L; 21:17547155-17547155	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1017G>T; p.K339N; 21:17565611-17565611	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.814G>A; p.E272K; 21:17561457-17561457	skin	malignant_melanoma	Substitution - Missense
c.405G>T; p.L135L; 21:17551943-17551943	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.477G>A; p.K159K; 21:17559037-17559037	skin	malignant_melanoma	Substitution - coding silent
c.1026C>T; p.A342A; 21:17565620-17565620	skin	malignant_melanoma	Substitution - coding silent
c.345T>C; p.I115I; 21:17551883-17551883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.30G>A; p.L10L; 21:17513159-17513159	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.30G>A; p.L10L; 21:17513159-17513159	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.30G>A; p.L10L; 21:17513159-17513159	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.131C>T; p.T44M; 21:17547114-17547114	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.324G>A; p.T108T; 21:17551862-17551862	breast	carcinoma	Substitution - coding silent
c.324G>A; p.T108T; 21:17551862-17551862	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.324G>A; p.T108T; 21:17551862-17551862	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.33C>A; p.C11*; 21:17513162-17513162	pancreas	carcinoma	Substitution - Nonsense
c.748C>T; p.L250L; 21:17561391-17561391	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1069G>A; p.A357T; 21:17565663-17565663	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.625A>C; p.T209P; 21:17560755-17560755	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.885C>T; p.I295I; 21:17565479-17565479	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.602_603insAAA; p.K200_N201insK; 21:17560732-17560733	prostate	carcinoma	Insertion - In frame
c.106A>G; p.T36A; 21:17547089-17547089	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.903C>T; p.S301S; 21:17565497-17565497	skin	malignant_melanoma	Substitution - coding silent
c.676C>T; p.R226C; 21:17560806-17560806	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.753G>A; p.A251A; 21:17561396-17561396	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.753G>A; p.A251A; 21:17561396-17561396	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.753G>A; p.A251A; 21:17561396-17561396	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1013C>T; p.A338V; 21:17565607-17565607	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.768C>T; p.I256I; 21:17561411-17561411	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.115C>G; p.L39V; 21:17547098-17547098	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.269G>A; p.R90Q; 21:17551807-17551807	liver	carcinoma	Substitution - Missense
c.269G>A; p.R90Q; 21:17551807-17551807	liver	carcinoma	Substitution - Missense
c.421C>T; p.P141S; 21:17558981-17558981	skin	malignant_melanoma	Substitution - Missense
c.205C>T; p.Q69*; 21:17547188-17547188	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.786A>G; p.K262K; 21:17561429-17561429	breast	carcinoma	Substitution - coding silent
c.66C>T; p.I22I; 21:17547049-17547049	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.343A>G; p.I115V; 21:17551881-17551881	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.629A>G; p.Y210C; 21:17560759-17560759	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.766A>G; p.I256V; 21:17561409-17561409	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.771C>T; p.I257I; 21:17561414-17561414	skin	malignant_melanoma	Substitution - coding silent
c.630C>A; p.Y210*; 21:17560760-17560760	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.572-1G>A; p.?; 21:17560701-17560701	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.22G>A; p.V8M; 21:17513151-17513151	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.534G>A; p.L178L; 21:17559094-17559094	breast	carcinoma	Substitution - coding silent
c.734G>A; p.G245E; 21:17561377-17561377	breast	carcinoma	Substitution - Missense
c.485G>A; p.C162Y; 21:17559045-17559045	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.690C>G; p.V230V; 21:17560820-17560820	breast	carcinoma	Substitution - coding silent
c.392A>G; p.K131R; 21:17551930-17551930	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.923C>T; p.S308F; 21:17565517-17565517	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.833+2T>C; p.?; 21:17561478-17561478	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.79G>A; p.E27K; 21:17547062-17547062	skin	malignant_melanoma	Substitution - Missense
c.791G>A; p.R264H; 21:17561434-17561434	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.993G>C; p.Q331H; 21:17565587-17565587	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.487G>A; p.E163K; 21:17559047-17559047	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1070C>G; p.A357G; 21:17565664-17565664	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation