COMT gene polymorphism is associated with non-small cell lung cancer.

Data show that the L858R mutation of EGFR is associated with SNP of estrogen biosynthesis and metabolism genes CYP17, CYP19A1, ERalpha, and COMT in never-smoking female lung adenocarcinoma patients.

The COMT rs4680 A allele was positively associated with lung cancer in Singapore Chinese female never smokers (for G/A or A/A vs. G/G, OR = 1.46, 95% CI: 1.12, 1.90) but not in ever smokers.

Patients with the COMT rs4680 single-nucleotide polymorphism G allele had a reduced risk of developing non-small-cell lung cancer, especially a risk of developing adenocarcinoma.

findings suggested that the COMT l58Val/Met polymorphism confer genetic susceptibility to lung cancer among women [Meta-Analysis]

CYP2E1 rs2031920 and COMT rs4680 are not major contributors to lung cancer risk.

T-77C and Arg399Gln polymorphisms of the XRCC1 gene, as well as the 186C>T and Val158Met polymorphisms of the COMT gene, increased the risk of lung cancer in non-smoking women.

When green tea drinkers from Taiwan carrying COMT HL/LL genotypes were selected as the reference group, drinkers carrying the COMT HH genotype had a higher risk for the development of lung cancer. Among the current and ever smokers, the elevated risk for lung cancer was more apparent in green tea drinkers carrying the COMT HH genotype compared with green tea drinkers carrying COMT HL/LL genotypes.