| Gene ID | 1312 |
| Symbol | COMT |
| Synonymous | HEL-S-98n |
| Full name | catechol-O-methyltransferase |
| Gene description | catechol O-methyltransferase|epididymis secretory sperm binding protein Li 98n |
| Cytoband | 22q11.21 |
| Gene type | protein-coding |
| Synonymous | MIM:116790; HGNC:HGNC:2228; Ensembl:ENSG00000093010; HPRD:00284; Vega:OTTHUMG00000150529 |
Pathways and Diseases | Detail |
|---|---|
Pathway | Steroid hormone biosynthesis;KEGG PATHWAY;hsa00140 |
Pathway | noradrenaline and adrenaline degradation;BioCyc;PWY-6342 |
Pathway | Dopamine clearance from the synaptic cleft;PID Reactome;500155 |
Pathway | Tyrosine metabolism;KEGG PATHWAY;hsa00350 |
Pathway | Enzymatic degradation of Dopamine by monoamine oxidase;PID Reactome;500157 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | Enzymatic degradation of dopamine by COMT;PID Reactome;500156 |
Pathway | Biological oxidations;Reactome;REACT:13433 |
Pathway | Synaptic Transmission;Reactome;REACT:13685 |
Pathway | Adrenaline and noradrenaline biosynthesis;PANTHER;P00001 |
Pathway | dopamine degradation;BioCyc;PWY6666-2 |
Pathway | Methylation;PID Reactome;500215 |
Pathway | L-dopa degradation;BioCyc;PWY-6334 |
Disease | oxidative stress;GAD |
Disease | performance on the Wisconsin Card Sorting Test;GAD |
Disease | information processing;GAD |
Disease | obsessive compusive diorder;GAD |
Disease | estradiol;GAD |
Disease | Arthralgia;GAD |
Disease | obesity;GAD |
Disease | menarche;GAD |
Disease | AGING;GAD |
Disease | schizotypal traits;GAD |
Disease | neuroticism;GAD |
Disease | personality disorders;GAD |
Disease | hypertension;GAD |
Disease | psychoses;GAD |
Disease | anorexia nervosa;GAD |
Disease | cognitive function;GAD |
Disease | Depression, Postpartum;GAD |
Disease | Parkinson's disease;GAD |
Disease | obsessive compulsive disorder;GAD |
Disease | PHARMACOGENOMIC;GAD |
Disease | panic disorder;GAD |
Disease | hormone disturbance;GAD |
Disease | alcoholism;GAD |
Disease | Schizophrenia, susceptibility to;OMIM |
Disease | sex hormone binding globulin;GAD |
Disease | METABOLIC;GAD |
Disease | menopause;GAD |
Disease | heroin abuse;GAD |
Disease | PSYCH;GAD |
Disease | CHEMDEPENDENCY;GAD |
Disease | eating disorders;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | ovarian cancer;GAD |
Disease | CANCER;GAD |
Disease | prostate carcinoma;GAD |
Disease | Panic disorder, susceptibility to;OMIM |
Disease | Weight Gain;GAD |
Disease | bipolar affective disorder.;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | psychiatric manifestations of velo-cardio-facial syndrome;GAD |
Disease | REPRODUCTION;GAD |
Disease | major depressive disorder;GAD |
Disease | smoking cessation;GAD |
Disease | suicide;GAD |
Disease | adenomyosis endometriosis;GAD |
Disease | breast cancer;GAD |
Disease | schizophrenia;GAD |
Disease | Osteoarthritis, Hip;GAD |
Disease | bipolar disorder;GAD |
Disease | aggressive personality traits;GAD |
Disease | skeletal muscle properties;GAD |
Sequence Information | |
|---|---|
Nucleotide Sequence | >1312 : length: 2304 CGGCCTGCGTCCGCCACCGGAAGCGCCCTCCTAATCCCCGCAGCGCCACCGCCATTGCCGCCATCGTCGTGGGGCTTCTGGGGCAGCTAGGGCTGCCCGCCGCGCTGCCTGCGCCGGACC GGGGCGGGTCCAGTCCCGGGCGGGCCGTCGCGGGAGAGAAATAACATCTGCTTTGCTGCCGAGCTCAGAGGAGACCCCAGACCCCTCCCGCAGCCAGAGGGCTGGAGCCTGCTCAGAGGT GCTTTGAAGATGCCGGAGGCCCCGCCTCTGCTGTTGGCAGCTGTGTTGCTGGGCCTGGTGCTGCTGGTGGTGCTGCTGCTGCTTCTGAGGCACTGGGGCTGGGGCCTGTGCCTTATCGGC TGGAACGAGTTCATCCTGCAGCCCATCCACAACCTGCTCATGGGTGACACCAAGGAGCAGCGCATCCTGAACCACGTGCTGCAGCATGCGGAGCCCGGGAACGCACAGAGCGTGCTGGAG GCCATTGACACCTACTGCGAGCAGAAGGAGTGGGCCATGAACGTGGGCGACAAGAAAGGCAAGATCGTGGACGCCGTGATTCAGGAGCACCAGCCCTCCGTGCTGCTGGAGCTGGGGGCC TACTGTGGCTACTCAGCTGTGCGCATGGCCCGCCTGCTGTCACCAGGGGCGAGGCTCATCACCATCGAGATCAACCCCGACTGTGCCGCCATCACCCAGCGGATGGTGGATTTCGCTGGC GTGAAGGACAAGGTCACCCTTGTGGTTGGAGCGTCCCAGGACATCATCCCCCAGCTGAAGAAGAAGTATGATGTGGACACACTGGACATGGTCTTCCTCGACCACTGGAAGGACCGGTAC CTGCCGGACACGCTTCTCTTGGAGGAATGTGGCCTGCTGCGGAAGGGGACAGTGCTACTGGCTGACAACGTGATCTGCCCAGGTGCGCCAGACTTCCTAGCACACGTGCGCGGGAGCAGC TGCTTTGAGTGCACACACTACCAATCGTTCCTGGAATACAGGGAGGTGGTGGACGGCCTGGAGAAGGCCATCTACAAGGGCCCAGGCAGCGAAGCAGGGCCCTGACTGCCCCCCCGGCCC CCCTCTCGGGCTCTCTCACCCAGCCTGGTACTGAAGGTGCCAGACGTGCTCCTGCTGACCTTCTGCGGCTCCGGGCTGTGTCCTAAATGCAAAGCACACCTCGGCCGAGGCCTGCGCCCT GACATGCTAACCTCTCTGAACTGCAACACTGGATTGTTCTTTTTTAAGACTCAATCATGACTTCTTTACTAACACTGGCTAGCTATATTATCTTATATACTAATATCATGTTTTAAAAAT ATAAAATAGAAATTAAGAATCTAAATATTTAGATATAACTCGACTTAGTACATCCTTCTCAACTGCCATTCCCCTGCTGCCCTTGACTTGGGCACCAAACATTCAAAGCTCCCCTTGACG GACGCTAACGCTAAGGGCGGGGCCCCTAGCTGGCTGGGTTCTGGGTGGCACGCCTGGCCCACTGGCCTCCCAGCCACAGTGGTGCAGAGGTCAGCCCTCCTGCAGCTAGGCCAGGGGCAC CTGTTAGCCCCATGGGGACGACTGCCGGCCTGGGAAACGAAGAGGAGTCAGCCAGCATTCACACCTTTCTGACCAAGCAGGCGCTGGGGACAGGTGGACCCCGCAGCAGCACCAGCCCCT CTGGGCCCCATGTGGCACAGAGTGGAAGCATCTCCTTCCCTACTCCCCACTGGGCCTTGCTTACAGAAGAGGCAATGGCTCAGACCAGCTCCCGCATCCCTGTAGTTGCCTCCCTGGCCC ATGAGTGAGGATGCAGTGCTGGTTTCTGCCCACCTACACCTAGAGCTGTCCCCATCTCCTCCAAGGGGTCAGACTGCTAGCCACCTCAGAGGCTCCAAGGGCCCAGTTCCCAGGCCCAGG ACAGGAATCAACCCTGTGCTAGCTGAGTTCACCTGCACCGAGACCAGCCCCTAGCCAAGATTCTACTCCTGGGCTCAAGGCCTGGCTAGCCCCCAGCCAGCCCACTCCTATGGATAGACA GACCAGTGAGCCCAAGTGGACAAGTTTGGGGCCACCCAGGGACCAGAAACAGAGCCTCTGCAGGACACAGCAGATGGGCACCTGGGACCACCTCCACCCAGGGCCCTGCCCCAGACGCGC AGAGGCCCGACACAAGGGAGAAGCCAGCCACTTGTGCCAGACCTGAGTGGCAGAAAGCAAAAAGTTCCTTTGCTGCTTTAATTTTTAAATTTTCTTACAAAAATTTAGGTGTTTACCAAT AGTCTTATTTTGGCTTATTTTTAA |
Protein Sequence | >1312 : length: 330 MMLLCILGNNICFAAELRGDPRPLPQPEGWSLLRGALKMPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTY CEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTL LLEVQWSGVFQSADVFCIPDDQIGLLSPLAQPEKSRSPGPSLMHSLAQTGRQPPCSRPRPLSSSRVALCSTSFQLTLLGHFFFFLNENTS |