CCR1 contributes to human non-small cell lung cancer cell migration by stimulating cell invasion, independent of cell proliferation.

expression of CCR1 was measured in retrospective clinical specimens of colorectal cancer lung metastases. CCR1+ cells accumulated around the CCL15-positive colorectal cancer cells in the lung, but few around the CCL15-negative ones.

Low CCR1 expression is associated with the development of lung adenocarcinoma.

MiR-126-3p was significantly down-regulated in non-small cell lung cancer (NSCLC) cell lines and tissues. The up-regulation of miR-126-3p inhibited the growth, colony formation, migration and invasion of NSCLC cell. Xenograft model indicated that miR-126-3p suppressed NSCLC cell growth and lung metastasis by targeting chemokine (C-C motif) receptor 1 (CCR1).