The results suggest that alpha7nAChR has a central role in modulating the response to chronic cigarette smoking that could include altering susceptibility to associated lung diseases including fibrosis and cancer.

alpha7-subunit is constantly found in NE cells in normal lungs. In tumors, its expression is significantly higher in small-cell lung carcinoma than in carcinoid tumor (p=0.009)

These results showed that alpha7-nAChR plays an important role in non-small cell lung cancer cell growth and tumour progression as well as in cell death.

Nicotine-treated non-small cell lung cancer cells showed significant induction of the alpha7nAChR and alpha4nAChR, along with significant inductions of p-CREB and p-ERK1/2.

The CNV-3956 of CHRNA7 contributed to increased risks and poor prognoses of both COPD and lung cancer, and this may be a genetic biomarker of the two diseases.

these results indicate that nicotine induces non-small cell lung cancer cell invasion, migration, and epithelial to mesenchymal transition ; the effects are mediated by alpha7-nAChRs and involve MEK/ERK signaling pathway

These findings demonstrate that a7nAChR plays an important role in H1299 cell proliferation, tumor growth and expression of vimentin. Therefore, blocking a7nAChRs in non-small cell lung cancer (NSCLC) may be a potential adjuvant therapy for the targeted treatment of NSCLC