lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	1139
Symbol	CHRNA7
Synonymous	CHRNA7-2\|NACHRA7
Full name	cholinergic receptor, nicotinic, alpha 7 (neuronal)
Gene description	a7 nicotinic acetylcholine receptor\|alpha 7 neuronal nicotinic acetylcholine receptor\|alpha-7 nicotinic cholinergic receptor subunit\|cholinergic receptor, nicotinic, alpha polypeptide 7\|neuronal acetylcholine receptor protein, alpha-7 chain\|neuronal acety
Cytoband	15q14
Gene type	protein-coding
Synonymous	MIM:118511; HGNC:HGNC:1960; Ensembl:ENSG00000175344; HPRD:00339; Vega:OTTHUMG00000129285

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.109T>A; p.Y37N; 15:32030951-32030951	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.109T>A; p.Y37N; 15:32030951-32030951	urinary_tract; bladder	carcinoma	Substitution - Missense
c.742G>T; p.A248S; 15:32158555-32158555	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.196-4G>T; p.?; 15:32101299-32101299	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.196-4G>T; p.?; 15:32101299-32101299	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.196-4G>T; p.?; 15:32101299-32101299	liver	carcinoma	Unknown
c.1060C>T; p.R354C; 15:32168009-32168009	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.643G>A; p.E215K; 15:32158456-32158456	skin	malignant_melanoma	Substitution - Missense
c.1119C>T; p.A373A; 15:32168068-32168068	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.111delC; p.Y37fs*1; 15:32030953-32030953	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.851C>A; p.P284H; 15:32159626-32159626	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1044C>T; p.P348P; 15:32167993-32167993	thyroid	other; neoplasm	Substitution - coding silent
c.599G>A; p.G200E; 15:32158412-32158412	skin	malignant_melanoma	Substitution - Missense
c.12G>T; p.S4S; 15:32030606-32030606	liver	carcinoma	Substitution - coding silent
c.246G>A; p.W82*; 15:32111795-32111795	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Nonsense
c.61C>A; p.L21M; 15:32030903-32030903	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1135G>A; p.A379T; 15:32168084-32168084	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1104T>C; p.S368S; 15:32168053-32168053	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.72G>C; p.E24D; 15:32030914-32030914	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.866C>T; p.S289L; 15:32159641-32159641	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.267G>A; p.W89*; 15:32111816-32111816	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.689C>T; p.T230M; 15:32158502-32158502	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1117G>T; p.A373S; 15:32168066-32168066	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.683G>T; p.R228L; 15:32158496-32158496	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1144G>A; p.G382R; 15:32168093-32168093	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1144G>A; p.G382R; 15:32168093-32168093	skin	malignant_melanoma	Substitution - Missense
c.834C>T; p.L278L; 15:32159609-32159609	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.960C>T; p.H320H; 15:32163305-32163305	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.712C>T; p.L238L; 15:32158525-32158525	breast	carcinoma	Substitution - coding silent
c.871C>T; p.P291S; 15:32159646-32159646	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.712C>T; p.L238L; 15:32158525-32158525	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1303A>G; p.K435E; 15:32168252-32168252	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1153C>T; p.L385L; 15:32168102-32168102	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.807A>C; p.L269F; 15:32159582-32159582	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.606C>T; p.P202P; 15:32158419-32158419	skin	malignant_melanoma	Substitution - coding silent
c.1096C>A; p.L366M; 15:32168045-32168045	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1075C>T; p.H359Y; 15:32168024-32168024	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.332A>G; p.D111G; 15:32111881-32111881	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.332A>G; p.D111G; 15:32111881-32111881	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.648C>G; p.P216P; 15:32158461-32158461	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.296C>T; p.T99I; 15:32111845-32111845	skin	malignant_melanoma	Substitution - Missense
c.783G>T; p.K261N; 15:32158596-32158596	breast	carcinoma	Substitution - Missense
c.157G>A; p.V53I; 15:32030999-32030999	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.891C>T; p.F297F; 15:32163236-32163236	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.891C>T; p.F297F; 15:32163236-32163236	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1131G>A; p.P377P; 15:32168080-32168080	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1269C>T; p.G423G; 15:32168218-32168218	thyroid	other; neoplasm	Substitution - coding silent
c.1269C>T; p.G423G; 15:32168218-32168218	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1354G>A; p.E452K; 15:32168303-32168303	thyroid	other; neoplasm	Substitution - Missense
c.1466C>T; p.S489L; 15:32168415-32168415	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1466C>T; p.S489L; 15:32168415-32168415	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1466C>T; p.S489L; 15:32168415-32168415	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1466C>T; p.S489L; 15:32168415-32168415	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1466C>T; p.S489L; 15:32168415-32168415	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1466C>T; p.S489L; 15:32168415-32168415	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1146G>A; p.G382G; 15:32168095-32168095	skin	malignant_melanoma	Substitution - coding silent
c.961G>T; p.D321Y; 15:32163306-32163306	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1085G>A; p.R362Q; 15:32168034-32168034	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.650A>G; p.Y217C; 15:32158463-32158463	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1061G>A; p.R354H; 15:32168010-32168010	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.234G>T; p.L78L; 15:32101341-32101341	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.783G>A; p.K261K; 15:32158596-32158596	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.351-2A>G; p.?; 15:32153905-32153905	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1335C>T; p.N445N; 15:32168284-32168284	breast	carcinoma	Substitution - coding silent
c.1335C>T; p.N445N; 15:32168284-32168284	thyroid	other; neoplasm	Substitution - coding silent
c.690G>A; p.T230T; 15:32158503-32158503	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.690G>A; p.T230T; 15:32158503-32158503	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.690G>A; p.T230T; 15:32158503-32158503	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1335C>T; p.N445N; 15:32168284-32168284	breast	carcinoma	Substitution - coding silent
c.1335C>T; p.N445N; 15:32168284-32168284	thyroid	other; neoplasm	Substitution - coding silent
c.690G>A; p.T230T; 15:32158503-32158503	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.690G>A; p.T230T; 15:32158503-32158503	breast	carcinoma	Substitution - coding silent
c.690G>A; p.T230T; 15:32158503-32158503	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.690G>A; p.T230T; 15:32158503-32158503	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.690G>A; p.T230T; 15:32158503-32158503	thyroid	other; neoplasm	Substitution - coding silent
c.1335C>T; p.N445N; 15:32168284-32168284	breast	carcinoma	Substitution - coding silent
c.690G>A; p.T230T; 15:32158503-32158503	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.969C>T; p.D323D; 15:32163314-32163314	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.595G>A; p.V199M; 15:32157772-32157772	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.33G>T; p.A11A; 15:32030627-32030627	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.701G>A; p.G234D; 15:32158514-32158514	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_B_cell_leukaemia	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation