mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors.

lung cancer cells from people with impaired CHEK2 function undergo increased rates of cell death.

down-regulation of CHK2 gene via distal promoter CpG islands methylation may play a role in the pathogenesis of non-small cell lung cancers

CHEK2 rs2236141 variant modifies lung cancer susceptibility in the Chinese population by affecting CHEK2 expression.

CHEK2 p.Ile157Thr is associated with lung cancer.

High CHEK2 expression is associated with lung Adenocarcinoma.

Results demonstrate that CHK2 is deubiquitinated by USP39 enhancing its stability. CHK2 regulates cell cycle checkpoint, cell apoptosis and chemo-radiation response. Furthermore, USP39 and CHK2 expression are correlatively downregulated in lung cancer samples.