| Gene ID | 11200 |
| Symbol | CHEK2 |
| Synonymous | CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1 |
| Full name | checkpoint kinase 2 |
| Gene description | CHK2 checkpoint homolog|cds1 homolog|checkpoint-like protein CHK2|serine/threonine-protein kinase Chk2 |
| Cytoband | 22q12.1 |
| Gene type | protein-coding |
| Synonymous | MIM:604373; HGNC:HGNC:16627; Ensembl:ENSG00000183765; HPRD:05084; Vega:OTTHUMG00000151023 |
Pathways and Diseases | Detail |
|---|---|
Pathway | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;PID Reactome;500938 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | cell cycle: g2/m checkpoint;PID BioCarta;100159 |
Pathway | PLK3 signaling events;PID Curated;200186 |
Pathway | Cell Cycle Checkpoints;Reactome;REACT:1538 |
Pathway | role of brca1 brca2 and atr in cancer susceptibility;PID BioCarta;100234 |
Pathway | G2/M DNA damage checkpoint;PID Reactome;500952 |
Pathway | regulation of cell cycle progression by plk3;PID BioCarta;100068 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | FOXM1 transcription factor network;PID Curated;200120 |
Pathway | atm signaling pathway;PID BioCarta;100235 |
Pathway | p53 pathway;PID Curated;200175 |
Disease | Breast and colorectal cancer, susceptibility to;OMIM |
Disease | Vertical cup-disc ratio;NHGRI |
Disease | overall effect;GAD |
Disease | cancer;GAD |
Disease | Cancer;FunDO |
Disease | Prostate cancer, familial, susceptibility to;OMIM |
Disease | Leukoencephalopathy;FunDO |
Disease | prostate cancer;GAD |
Disease | METABOLIC;GAD |
Disease | estrogen receptor status;GAD |
Disease | upper aerodigestive tract cancer;GAD |
Disease | colorectal cancer;GAD |
Disease | diabetes, type 2;GAD |
Disease | endometrial cancer;GAD |
Disease | CANCER;GAD |
Disease | Yersinia infection;FunDO |
Disease | Li-Fraumeni syndrome;OMIM |
Disease | breast cancer;GAD |
Disease | Breast cancer, susceptibility to;OMIM |
Disease | Osteosarcoma, somatic;OMIM |
Disease | ovarian cancer;GAD |
Disease | Esophageal cancer and gastric cancer;NHGRI |
Sequence Information | |
|---|---|
Nucleotide Sequence | >11200 : length: 1991 GCAGGTTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTGTGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGT GCCTGTTCACAGCCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGCCAGTCCTCTCACTCCAGC TCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCTGAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTA TGGGCCCTTCAGGATGGATTTGCCAATCTTGAGACAGAGTCTGGCCATGTTACCCAATCTGATCTTGAACTCCTGCTGTCATCTGATCCTCCTGCCTCAGCCTCCCAAAGTGCTGGGATA AGAGGTGTGAGGCACCATCCCCGGCCAGTTTGCAGTCTAAAATGTGTGAATGACAACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACA GATAAATACCGAACATACAGCAAGAAACACTTTCGGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTAAATACAGAG CTTGTAGGGAAAGGAAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGTTTTTGTCTTTTTTGATCTGACTGTAGATGATCAGTCAGTTTATCCT AAGGCATTAAGAGATGAATACATCATGTCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAGGAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGCAAA AGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAAATAGAAATTTTGAAAAAGCTAAATCATCCTTGCATCATCAAGATTAAAAACTTTTTTGAT GCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGGGAGAGCTGTTTGACAAAGTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTG GCTGTGCAGTACCTTCATGAAAACGGTATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCCAAG ATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCTGGGTATAACCGTGCTGTGGACTGCTGGAGTTTA GGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACTCAAGTGTCACTGAAGGATCAGATCACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCA GAAGTCTCAGAGAAAGCTCTGGACCTTGTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCACGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAGAGA AAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAGCTCTACCCCAGGTTCTAGCCCAGCCTTCTACTAGTCGAAAGCGGCCCCGTGAAGGGGAAGCCGAGGGTGCCGAGACCACA AAGCGCCCAGCTGTGTGTGCTGCTGTGTTGTGAACTCCGTGGTTTGAACACGAAAGAAATGTACCTTCTTTCACTCTGTCATCTTTCTTTTCTTTGAGTCTGTTTTTTTATAGTTTGTAT TTTAATTATGGGAATAATTGCTTTTTCACAGTCACTGATGTACAATTAAAAACCTGATGGAACCTGGAAAA |
Protein Sequence | >11200 : length: 596 MLRLLTSMVVMSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLETES GHVTQSDLELLLSSDPPASASQSAGIRGVRHHPRPVCSLKCVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNS EIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGG ELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPF SEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL |