Promoter methylation of Wnt inhibitory factor-1 is associated with lung cancer.

procaine and procainamide reactivate WIF-1 in lung cancer cells and downregulate the Wnt canonical pathway

The miR-29 family (miR-29a, -29b, and -29c) suppresses the Wnt signaling pathway through demethylation of WIF-1 in non-small-cell lung cancer.

Ihh is a marker for poor prognosis in patients with lung squamous cell carcinoma and adenocarcinoma. WIF-1 is not a predictive marker for lung cancer.

Data show the frequency of WIF-1 hypermethylation significantly increased in non-small cell lung cancer (NSCLC) specimens compared with normal lung tissue. WIF-1 hypermethylation is predominant in squamous cell carcinoma (SCC), suggesting that WIF-1 methylation contributes to the development of NSCLC, especially SCC. [review]

Promoter hypermethylation WIF1 play an important role in the carcinogenesis of lung cancer.

Data revealed that the upregulation of WIF1 induced autophagy in non-small cell lung cancer (NSCLC) cells. WIF1-mediated autophagy was demonstrated to inhibit Wnt/betacatenin signaling by downregulating Dvl2, which contributed to the inhibition of the proliferation and the promotion of the apoptosis of NSCLC cells.