Real-time PCR analysis reveals that the ratio of RIP3 gamma to RIP3 is significantly increased in colon and lung cancers relative to their matched normal tissues, indicating that RIP3 gamma might be a splice form associated with tumorigenesis.

expression level of receptor-interacting protein kinase 3 (RIPK3) in cisplatin-resistant A549 (A549/DDP) cells is lower. RIPK3 expression level which influences cisplatin sensitivity of lung cancer cells is regulated by CCR4-NOT transcription complex subunit 3 (CNOT3). CNOT3 depletion up-regulates the expression level of RIPK3 and enhances apoptosis by elevating RIPK3 to further trigger Caspase 8 activation.

ID1 overexpression increases gefitinib sensitivity in non-small cell lung cancer by activating RIP3/MLKL-dependent necroptosis.