lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	11035
Symbol	RIPK3
Synonymous	RIP3
Full name	receptor-interacting serine-threonine kinase 3
Gene description	RIP-3\|RIP-like protein kinase 3\|receptor interacting protein 3\|receptor-interacting protein 3\|receptor-interacting serine/threonine-protein kinase 3
Cytoband	14q11.2
Gene type	protein-coding
Synonymous	MIM:605817; HGNC:HGNC:10021; Ensembl:ENSG00000129465; HPRD:09315; Vega:OTTHUMG00000029349

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1475delC; p.P492fs*3; 14:24336257-24336257	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1126G>A; p.E376K; 14:24337235-24337235	skin	malignant_melanoma	Substitution - Missense
c.1231C>T; p.P411S; 14:24337130-24337130	skin	malignant_melanoma	Substitution - Missense
c.1372G>A; p.V458M; 14:24336360-24336360	skin	malignant_melanoma	Substitution - Missense
c.244G>A; p.V82M; 14:24339242-24339242	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1442C>T; p.P481L; 14:24336290-24336290	skin	malignant_melanoma	Substitution - Missense
c.621C>T; p.F207F; 14:24338292-24338292	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.136G>A; p.D46N; 14:24339482-24339482	breast	carcinoma	Substitution - Missense
c.1372delG; p.V458fs*9; 14:24336360-24336360	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1347C>T; p.L449L; 14:24336385-24336385	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1173G>A; p.S391S; 14:24337188-24337188	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1445C>T; p.S482L; 14:24336287-24336287	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.246G>A; p.V82V; 14:24339240-24339240	skin	malignant_melanoma	Substitution - coding silent
c.167C>T; p.A56V; 14:24339319-24339319	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.246G>A; p.V82V; 14:24339240-24339240	skin	malignant_melanoma	Substitution - coding silent
c.271G>T; p.A91S; 14:24339215-24339215	prostate	carcinoma	Substitution - Missense
c.111G>A; p.R37R; 14:24339507-24339507	central_nervous_system; brain	glioma	Substitution - coding silent
c.111G>A; p.R37R; 14:24339507-24339507	central_nervous_system; brain	glioma	Substitution - coding silent
c.298G>A; p.G100S; 14:24339188-24339188	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1224G>A; p.M408I; 14:24337137-24337137	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.372G>A; p.V124V; 14:24339114-24339114	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.398A>T; p.D133V; 14:24339088-24339088	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1493A>G; p.E498G; 14:24336239-24336239	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.215T>C; p.V72A; 14:24339271-24339271	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.70C>T; p.Q24*; 14:24339548-24339548	breast	carcinoma	Substitution - Nonsense
c.1477C>T; p.P493S; 14:24336255-24336255	skin	malignant_melanoma	Substitution - Missense
c.184A>G; p.K62E; 14:24339302-24339302	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.30T>A; p.G10G; 14:24339588-24339588	breast	carcinoma	Substitution - coding silent
c.38C>T; p.A13V; 14:24339580-24339580	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.240G>A; p.E80E; 14:24339246-24339246	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1150A>G; p.T384A; 14:24337211-24337211	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1508C>T; p.P503L; 14:24336224-24336224	skin	malignant_melanoma	Substitution - Missense
c.1150A>G; p.T384A; 14:24337211-24337211	urinary_tract; bladder	carcinoma	Substitution - Missense
c.448C>T; p.L150L; 14:24339038-24339038	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - coding silent
c.1092delA; p.K364fs*69; 14:24337269-24337269	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.226G>C; p.E76Q; 14:24339260-24339260	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1301G>C; p.W434S; 14:24336920-24336920	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.323C>A; p.S108Y; 14:24339163-24339163	liver	carcinoma	Substitution - Missense
c.466G>A; p.V156I; 14:24339020-24339020	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.323C>A; p.S108Y; 14:24339163-24339163	liver	carcinoma	Substitution - Missense
c.1510G>A; p.E504K; 14:24336222-24336222	skin	malignant_melanoma	Substitution - Missense
c.1301G>C; p.W434S; 14:24336920-24336920	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1255C>T; p.P419S; 14:24337106-24337106	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1124A>G; p.Q375R; 14:24337237-24337237	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1322C>T; p.P441L; 14:24336899-24336899	pleura	pulmonary_blastoma	Substitution - Missense
c.1276G>A; p.G426R; 14:24336945-24336945	skin	malignant_melanoma	Substitution - Missense
c.421C>G; p.R141G; 14:24339065-24339065	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.633G>A; p.M211I; 14:24338280-24338280	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.709C>A; p.Q237K; 14:24337996-24337996	breast	carcinoma	Substitution - Missense
c.51C>T; p.S17S; 14:24339567-24339567	skin	malignant_melanoma	Substitution - coding silent
c.1317G>A; p.P439P; 14:24336904-24336904	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.967G>A; p.G323R; 14:24337394-24337394	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1254T>A; p.S418R; 14:24337107-24337107	breast	carcinoma	Substitution - Missense
c.334C>T; p.R112W; 14:24339152-24339152	skin	malignant_melanoma	Substitution - Missense
c.901-2A>T; p.?; 14:24337462-24337462	ovary	carcinoma; serous_carcinoma	Unknown
c.309G>A; p.S103S; 14:24339177-24339177	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1556A>G; p.519; 14:24336176-24336176	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1556A>G; p.519; 14:24336176-24336176	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1492G>A; p.E498K; 14:24336240-24336240	NS	malignant_melanoma	Substitution - Missense
c.110G>T; p.R37L; 14:24339508-24339508	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.324C>T; p.S108S; 14:24339162-24339162	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1446G>A; p.S482S; 14:24336286-24336286	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1132C>T; p.Q378*; 14:24337229-24337229	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.581T>A; p.V194E; 14:24338458-24338458	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1339C>T; p.R447*; 14:24336393-24336393	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1339C>T; p.R447*; 14:24336393-24336393	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.297C>T; p.N99N; 14:24339189-24339189	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.502G>A; p.G168R; 14:24338537-24338537	skin	malignant_melanoma	Substitution - Missense
c.1475C>A; p.P492Q; 14:24336257-24336257	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.565G>T; p.E189*; 14:24338474-24338474	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1230C>T; p.S410S; 14:24337131-24337131	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.304T>C; p.L102L; 14:24339182-24339182	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.304T>C; p.L102L; 14:24339182-24339182	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1473C>A; p.P491P; 14:24336259-24336259	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.213C>T; p.F71F; 14:24339273-24339273	skin	malignant_melanoma	Substitution - coding silent
c.1340G>A; p.R447Q; 14:24336392-24336392	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.691G>A; p.E231K; 14:24338014-24338014	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.375G>C; p.V125V; 14:24339111-24339111	pancreas	carcinoma	Substitution - coding silent
c.878A>T; p.N293I; 14:24337717-24337717	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1172C>T; p.S391L; 14:24337189-24337189	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1172C>T; p.S391L; 14:24337189-24337189	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.181G>A; p.V61I; 14:24339305-24339305	skin	malignant_melanoma	Substitution - Missense
c.308C>T; p.S103L; 14:24339178-24339178	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.421C>T; p.R141W; 14:24339065-24339065	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.332C>T; p.P111L; 14:24339154-24339154	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.221G>A; p.R74H; 14:24339265-24339265	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1348G>A; p.V450I; 14:24336384-24336384	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1348G>A; p.V450I; 14:24336384-24336384	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.129G>A; p.W43*; 14:24339489-24339489	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.158A>G; p.N53S; 14:24339460-24339460	skin	malignant_melanoma	Substitution - Missense
c.733C>T; p.L245L; 14:24337972-24337972	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.248A>T; p.N83I; 14:24339238-24339238	stomach	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation