TGF-beta release from platelets is necessary for podoplanin-mediated tumor invasion and metastasis in lung cancer.

Membranous podoplanin immunoreactivity, in conjunction with calretinin, would be more specific than CK5/6 and WT-1 in differentiating epithelioid malignant mesothelioma from adenocarcinoma of the lung, breast, and ovary.

Findings suggested that lung squamoid cancer cells -associated podoplanin was functional and could attenuate the potential for lymph node metastasis, possibly based on the suppression of tumor lymphangiogenesis

Suggest that immunohistochemical analysis for podoplanin may serve as a marker of risk of nodal metastasis and prognosis in patients with lung squamous cell carcinoma.

High podoplanin positive cancer-associated fibroblasts in metastatic lymph nodes is associated with lung adenocarcinoma

Because Aggrus knockdown suppressed platelet-induced proliferation in vitro and tumor growth of the lung squamous cell carcinoma in vivo, Aggrus may be involved in not only tumor metastasis but also tumor growth by promoting platelet-tumor interaction

High aggrus expression is associated with pulmonary metastasis in bladder cancer.

High PDPN expression is asasociated with lung adenocarcinoma.

podoplanin membrane expression, not only its localization, is a useful prognostic indicator of lung squamous cell carcinoma

We revealed that podoplanin expression in cancer-associated Fibroblasts was an independent indicator of worse prognosis, irrespective of the expression status of the tumor cells in patients with squamous cell carcinoma of the lung.

Podoplanin expression in cancer-associated fibroblasts could be an independent predictor of increased risk of recurrence in patients with p-stage IA lung adenocarcinoma.

In lung adenocarcinoma, the presence of podoplanin-positive cancer-associated fibroblasts (CAFs) was associated with higher numbers of single nucleotide variants (SNVs) in cancer cells.

Podoplanin+ fibroblast infiltration significantly decreased overall survival (OS) and disease-free survival in all types of solid tumors. In stratified analyses, podoplanin+ fibroblast infiltration was significantly associated with worse OS in cholangiocarcinoma, breast, lung and pancreatic cancer.

Results show that lung adenocarcinoma with podoplanin (PDPN+) cancer-associated fibroblasts (CAFs) is typified by the immunosuppressive microenvironment.