lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	10630
Symbol	PDPN
Synonymous	AGGRUS\|GP36\|GP40\|Gp38\|HT1A-1\|OTS8\|PA2.26\|T1A\|T1A-2\|T1A2\|TI1A
Full name	podoplanin
Gene description	PA2.26 antigen\|T1-alpha\|glycoprotein 36\|glycoprotein, 36-KD\|hT1alpha-1\|hT1alpha-2\|lung type I cell membrane associated glycoprotein\|lung type-I cell membrane-associated glycoprotein (T1A-2)
Cytoband	1p36.21
Gene type	protein-coding
Synonymous	MIM:608863; HGNC:HGNC:29602; Ensembl:ENSG00000162493; HPRD:16398; Vega:OTTHUMG00000007912

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.685A>G; p.M229V; 1:13614386-13614386	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.522C>T; p.S174S; 1:13610479-13610479	breast	carcinoma	Substitution - coding silent
c.494C>G; p.T165R; 1:13610451-13610451	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.499C>T; p.H167Y; 1:13610456-13610456	skin	malignant_melanoma	Substitution - Missense
c.46C>T; p.R16W; 1:13583851-13583851	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.46C>T; p.R16W; 1:13583851-13583851	skin	malignant_melanoma	Substitution - Missense
c.666T>C; p.G222G; 1:13614367-13614367	bone; pelvis	chondrosarcoma	Substitution - coding silent
c.640G>T; p.V214F; 1:13614341-13614341	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.348C>T; p.G116G; 1:13607225-13607225	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.353C>T; p.A118V; 1:13607230-13607230	liver	carcinoma	Substitution - Missense
c.353C>T; p.A118V; 1:13607230-13607230	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.353C>T; p.A118V; 1:13607230-13607230	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.353C>T; p.A118V; 1:13607230-13607230	liver	carcinoma	Substitution - Missense
c.366C>G; p.A122A; 1:13607243-13607243	skin	malignant_melanoma	Substitution - coding silent
c.269C>T; p.A90V; 1:13584074-13584074	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.269C>T; p.A90V; 1:13584074-13584074	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.153G>A; p.P51P; 1:13583958-13583958	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.64G>A; p.E22K; 1:13583869-13583869	urinary_tract; bladder	carcinoma	Substitution - Missense
c.114C>T; p.A38A; 1:13583919-13583919	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.114C>T; p.A38A; 1:13583919-13583919	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.465C>T; p.R155R; 1:13610422-13610422	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.693A>G; p.K231K; 1:13614394-13614394	liver	carcinoma	Substitution - coding silent
c.119C>T; p.P40L; 1:13583924-13583924	skin	malignant_melanoma	Substitution - Missense
c.388G>T; p.G130*; 1:13607265-13607265	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.311C>T; p.P104L; 1:13607188-13607188	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.311C>T; p.P104L; 1:13607188-13607188	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.711-2A>G; p.?; 1:13615903-13615903	thyroid	carcinoma	Unknown
c.676G>A; p.V226I; 1:13614377-13614377	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.676G>A; p.V226I; 1:13614377-13614377	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.503C>T; p.A168V; 1:13610460-13610460	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.441T>C; p.S147S; 1:13610398-13610398	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.542C>T; p.A181V; 1:13610499-13610499	skin	malignant_melanoma	Substitution - Missense
c.101C>T; p.P34L; 1:13583906-13583906	skin	malignant_melanoma	Substitution - Missense
c.273G>A; p.S91S; 1:13584078-13584078	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.117C>T; p.P39P; 1:13583922-13583922	breast	carcinoma	Substitution - coding silent
c.117C>T; p.P39P; 1:13583922-13583922	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.117C>T; p.P39P; 1:13583922-13583922	thyroid	other; neoplasm	Substitution - coding silent
c.117C>T; p.P39P; 1:13583922-13583922	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.321C>G; p.D107E; 1:13607198-13607198	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.367G>A; p.E123K; 1:13607244-13607244	pancreas	carcinoma	Substitution - Missense
c.693A>T; p.K231N; 1:13614394-13614394	skin	malignant_melanoma	Substitution - Missense
c.365C>T; p.A122V; 1:13607242-13607242	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.309G>A; p.Q103Q; 1:13607186-13607186	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.553T>C; p.S185P; 1:13610510-13610510	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.109C>T; p.P37S; 1:13583914-13583914	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.610A>G; p.T204A; 1:13614311-13614311	liver	carcinoma	Substitution - Missense
c.489A>T; p.E163D; 1:13610446-13610446	skin	malignant_melanoma	Substitution - Missense
c.295delG; p.A99fs*29; 1:13584100-13584100	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.320A>T; p.D107V; 1:13607197-13607197	urinary_tract; bladder	carcinoma	Substitution - Missense
c.469G>A; p.E157K; 1:13610426-13610426	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.469G>A; p.E157K; 1:13610426-13610426	skin	malignant_melanoma	Substitution - Missense
c.469G>A; p.E157K; 1:13610426-13610426	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.469G>A; p.E157K; 1:13610426-13610426	skin; arm	malignant_melanoma	Substitution - Missense
c.608C>T; p.S203L; 1:13614309-13614309	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.710C>T; p.S237L; 1:13614411-13614411	skin	malignant_melanoma	Substitution - Missense
c.656G>A; p.G219D; 1:13614357-13614357	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.205G>C; p.E69Q; 1:13584010-13584010	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.582G>T; p.Q194H; 1:13613709-13613709	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.504G>A; p.A168A; 1:13610461-13610461	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.232T>A; p.W78R; 1:13584037-13584037	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.429+1G>T; p.?; 1:13607307-13607307	lung	carcinoma; adenocarcinoma	Unknown
c.537C>T; p.N179N; 1:13610494-13610494	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.675C>T; p.I225I; 1:13614376-13614376	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.571G>A; p.G191R; 1:13613698-13613698	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.517C>T; p.P173S; 1:13610474-13610474	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.267C>T; p.S89S; 1:13584072-13584072	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.560-8A>G; p.?; 1:13613679-13613679	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Unknown
c.637_638delGG; p.V214fs*>25; 1:13614338-13614339	bone; pelvis	chondrosarcoma	Deletion - Frameshift
c.463C>T; p.R155C; 1:13610420-13610420	skin	malignant_melanoma	Substitution - Missense
c.159C>A; p.C53*; 1:13583964-13583964	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Nonsense
c.82C>T; p.L28F; 1:13583887-13583887	skin	malignant_melanoma	Substitution - Missense
c.698C>T; p.S233L; 1:13614399-13614399	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.487G>C; p.E163Q; 1:13610444-13610444	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.496G>A; p.V166I; 1:13610453-13610453	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.112_113insC; p.P41fs*67; 1:13583917-13583918	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.393C>A; p.T131T; 1:13607270-13607270	liver	carcinoma	Substitution - coding silent
c.242C>T; p.S81L; 1:13584047-13584047	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.655G>A; p.G219S; 1:13614356-13614356	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.368A>T; p.E123V; 1:13607245-13607245	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.654C>T; p.I218I; 1:13614355-13614355	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.501C>A; p.H167Q; 1:13610458-13610458	pancreas	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation