lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	94031
Symbol	HTRA3
Synonymous	Prsp\|Tasp
Full name	HtrA serine peptidase 3
Gene description	high-temperature requirement factor A3\|pregnancy-related serine protease\|probable serine protease HTRA3\|serine protease HTRA3
Cytoband	4p16.1
Gene type	protein-coding
Synonymous	MIM:608785; HGNC:HGNC:30406; Ensembl:ENSG00000170801; HPRD:08821; Vega:OTTHUMG00000090561

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.874G>A; p.D292N; 4:8291535-8291535	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.751C>T; p.R251W; 4:8291412-8291412	urinary_tract; bladder	carcinoma	Substitution - Missense
c.233G>A; p.R78H; 4:8270201-8270201	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1064G>A; p.R355H; 4:8302475-8302475	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.991G>A; p.A331T; 4:8294141-8294141	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.262G>A; p.A88T; 4:8270230-8270230	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1324G>A; p.D442N; 4:8306098-8306098	skin	malignant_melanoma	Substitution - Missense
c.785C>T; p.P262L; 4:8291446-8291446	skin	malignant_melanoma	Substitution - Missense
c.152G>T; p.C51F; 4:8270120-8270120	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.925C>T; p.L309L; 4:8292342-8292342	breast	carcinoma	Substitution - coding silent
c.474G>T; p.E158D; 4:8282525-8282525	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1276G>A; p.V426M; 4:8306050-8306050	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.745G>A; p.D249N; 4:8291406-8291406	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1236C>A; p.N412K; 4:8306010-8306010	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1313G>A; p.R438Q; 4:8306087-8306087	prostate	carcinoma	Substitution - Missense
c.1313G>A; p.R438Q; 4:8306087-8306087	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1120G>A; p.A374T; 4:8304203-8304203	skin	malignant_melanoma	Substitution - Missense
c.1120G>A; p.A374T; 4:8304203-8304203	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1318A>G; p.N440D; 4:8306092-8306092	thyroid	other; neoplasm	Substitution - Missense
c.907G>A; p.G303R; 4:8292324-8292324	skin	malignant_melanoma	Substitution - Missense
c.1146C>T; p.V382V; 4:8304229-8304229	kidney	other; neoplasm	Substitution - coding silent
c.1307T>G; p.V436G; 4:8306081-8306081	pancreas	carcinoma	Substitution - Missense
c.1056G>A; p.W352*; 4:8302467-8302467	skin	malignant_melanoma	Substitution - Nonsense
c.1085G>A; p.R362Q; 4:8302496-8302496	skin	malignant_melanoma	Substitution - Missense
c.1188T>G; p.P396P; 4:8304271-8304271	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.460G>A; p.V154M; 4:8282511-8282511	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1342G>T; p.A448S; 4:8306116-8306116	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1161T>A; p.Y387*; 4:8304244-8304244	breast	carcinoma	Substitution - Nonsense
c.906C>A; p.Y302*; 4:8292323-8292323	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.887C>T; p.T296M; 4:8291548-8291548	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.887C>T; p.T296M; 4:8291548-8291548	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1104G>C; p.L368L; 4:8304187-8304187	pancreas	carcinoma	Substitution - coding silent
c.1078C>T; p.R360W; 4:8302489-8302489	oesophagus	carcinoma	Substitution - Missense
c.1094C>T; p.T365I; 4:8302505-8302505	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.639C>T; p.D213D; 4:8286714-8286714	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.836G>A; p.R279Q; 4:8291497-8291497	central_nervous_system; brain	glioma	Substitution - Missense
c.1238G>A; p.G413E; 4:8306012-8306012	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.510G>A; p.V170V; 4:8286585-8286585	liver	carcinoma	Substitution - coding silent
c.510G>A; p.V170V; 4:8286585-8286585	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1241G>A; p.R414H; 4:8306015-8306015	pancreas	carcinoma	Substitution - Missense
c.820G>A; p.V274I; 4:8291481-8291481	central_nervous_system; brain	glioma	Substitution - Missense
c.842G>T; p.G281V; 4:8291503-8291503	kidney	other; neoplasm	Substitution - Missense
c.49G>T; p.A17S; 4:8270017-8270017	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.668A>G; p.D223G; 4:8286743-8286743	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.666C>T; p.I222I; 4:8286741-8286741	skin	malignant_melanoma	Substitution - coding silent
c.223G>A; p.E75K; 4:8270191-8270191	skin	malignant_melanoma	Substitution - Missense
c.968A>C; p.K323T; 4:8294118-8294118	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.819C>T; p.I273I; 4:8291480-8291480	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1015C>T; p.R339W; 4:8294165-8294165	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.65C>T; p.A22V; 4:8270033-8270033	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1342G>A; p.A448T; 4:8306116-8306116	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.948C>A; p.V316V; 4:8294098-8294098	thyroid	other; neoplasm	Substitution - coding silent
c.675G>T; p.K225N; 4:8286750-8286750	pancreas	carcinoma	Substitution - Missense
c.574G>A; p.V192M; 4:8286649-8286649	urinary_tract; bladder	carcinoma	Substitution - Missense
c.914_915CC>TT; p.S305F; 4:8292331-8292332	skin	malignant_melanoma	Substitution - Missense
c.1208A>G; p.Q403R; 4:8305982-8305982	skin	malignant_melanoma	Substitution - Missense
c.1208A>G; p.Q403R; 4:8305982-8305982	skin	malignant_melanoma	Substitution - Missense
c.1208A>G; p.Q403R; 4:8305982-8305982	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1208A>G; p.Q403R; 4:8305982-8305982	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1208A>G; p.Q403R; 4:8305982-8305982	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1208A>G; p.Q403R; 4:8305982-8305982	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.842G>A; p.G281D; 4:8291503-8291503	skin	malignant_melanoma	Substitution - Missense
c.483G>A; p.L161L; 4:8282534-8282534	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.483G>A; p.L161L; 4:8282534-8282534	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1088C>T; p.T363M; 4:8302499-8302499	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.503G>A; p.R168H; 4:8286578-8286578	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1323C>T; p.D441D; 4:8306097-8306097	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.992C>T; p.A331V; 4:8294142-8294142	urinary_tract; bladder	carcinoma	Substitution - Missense
c.586A>C; p.N196H; 4:8286661-8286661	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1285G>A; p.E429K; 4:8306059-8306059	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.634G>A; p.G212R; 4:8286709-8286709	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.410G>A; p.R137H; 4:8282461-8282461	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.777C>T; p.I259I; 4:8291438-8291438	skin	malignant_melanoma	Substitution - coding silent
c.835C>T; p.R279W; 4:8291496-8291496	central_nervous_system; cerebellum	primitive_neuroectodermal_tumour-medulloblastoma; SHH_subtype	Substitution - Missense
c.1311G>A; p.R437R; 4:8306085-8306085	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.835C>T; p.R279W; 4:8291496-8291496	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; medullomyoblastoma	Substitution - Missense
c.1179G>A; p.P393P; 4:8304262-8304262	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1179G>A; p.P393P; 4:8304262-8304262	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1312C>T; p.R438W; 4:8306086-8306086	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1179G>A; p.P393P; 4:8304262-8304262	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1212T>C; p.D404D; 4:8305986-8305986	liver	carcinoma	Substitution - coding silent
c.1212T>C; p.D404D; 4:8305986-8305986	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.637G>A; p.D213N; 4:8286712-8286712	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.501C>T; p.G167G; 4:8286576-8286576	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.514C>T; p.L172L; 4:8286589-8286589	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1161T>G; p.Y387*; 4:8304244-8304244	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.837G>A; p.R279R; 4:8291498-8291498	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.943G>A; p.E315K; 4:8294093-8294093	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation