lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	9046
Symbol	DOK2
Synonymous	p56DOK\|p56dok-2
Full name	docking protein 2, 56kDa
Gene description	docking protein 2\|docking protein 2, 56kD\|downstream of tyrosine kinase 2\|p56(dok-2)
Cytoband	8p21.3
Gene type	protein-coding
Synonymous	MIM:604997; HGNC:HGNC:2991; Ensembl:ENSG00000147443; HPRD:05411; Vega:OTTHUMG00000131075

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.562_563GG>TA; p.G188*; 8:21910728-21910729	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.182G>A; p.R61H; 8:21912392-21912392	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1129G>A; p.D377N; 8:21909421-21909421	skin	malignant_melanoma	Substitution - Missense
c.933G>T; p.G311G; 8:21909617-21909617	skin	malignant_melanoma	Substitution - coding silent
c.70C>T; p.R24C; 8:21912504-21912504	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.70C>T; p.R24C; 8:21912504-21912504	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.70C>T; p.R24C; 8:21912504-21912504	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.871C>T; p.R291W; 8:21909679-21909679	thyroid	carcinoma	Substitution - Missense
c.70C>T; p.R24C; 8:21912504-21912504	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_related	Substitution - Missense
c.272G>A; p.R91H; 8:21912302-21912302	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.288G>A; p.A96A; 8:21912286-21912286	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1234A>C; p.K412Q; 8:21909316-21909316	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.301G>A; p.E101K; 8:21912273-21912273	skin; extremity	malignant_melanoma	Substitution - Missense
c.922C>A; p.R308S; 8:21909628-21909628	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.424G>A; p.A142T; 8:21911910-21911910	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.479C>A; p.A160D; 8:21910812-21910812	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.255C>T; p.F85F; 8:21912319-21912319	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.505T>C; p.S169P; 8:21910786-21910786	breast	carcinoma	Substitution - Missense
c.46C>A; p.Q16K; 8:21913556-21913556	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.499delC; p.R167fs*41; 8:21910792-21910792	liver	carcinoma	Deletion - Frameshift
c.644G>A; p.R215H; 8:21909906-21909906	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.519G>T; p.R173R; 8:21910772-21910772	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1068C>T; p.L356L; 8:21909482-21909482	skin	malignant_melanoma	Substitution - coding silent
c.1068C>T; p.L356L; 8:21909482-21909482	skin	malignant_melanoma	Substitution - coding silent
c.562G>A; p.G188R; 8:21910729-21910729	skin	malignant_melanoma	Substitution - Missense
c.790C>A; p.L264M; 8:21909760-21909760	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.310G>A; p.D104N; 8:21912264-21912264	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.237G>A; p.R79R; 8:21912337-21912337	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.173A>C; p.K58T; 8:21912401-21912401	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.434-7T>A; p.?; 8:21910864-21910864	ovary	other; neoplasm	Unknown
c.612G>A; p.R204R; 8:21910679-21910679	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.765G>A; p.P255P; 8:21909785-21909785	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.765G>A; p.P255P; 8:21909785-21909785	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.915G>C; p.A305A; 8:21909635-21909635	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.684C>T; p.T228T; 8:21909866-21909866	ovary	other; neoplasm	Substitution - coding silent
c.765G>A; p.P255P; 8:21909785-21909785	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1079C>T; p.P360L; 8:21909471-21909471	skin	malignant_melanoma	Substitution - Missense
c.296C>A; p.A99E; 8:21912278-21912278	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.252C>A; p.F84L; 8:21912322-21912322	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.747A>G; p.A249A; 8:21909803-21909803	pleura	pulmonary_blastoma	Substitution - coding silent
c.73C>T; p.R25C; 8:21912501-21912501	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.10G>A; p.G4R; 8:21913592-21913592	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.516C>G; p.L172L; 8:21910775-21910775	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.117C>A; p.A39A; 8:21912457-21912457	liver	carcinoma	Substitution - coding silent
c.117C>A; p.A39A; 8:21912457-21912457	liver	carcinoma	Substitution - coding silent
c.838C>A; p.P280T; 8:21909712-21909712	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.21A>G; p.K7K; 8:21913581-21913581	prostate	carcinoma	Substitution - coding silent
c.299C>T; p.A100V; 8:21912275-21912275	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.500G>A; p.R167Q; 8:21910791-21910791	skin	malignant_melanoma	Substitution - Missense
c.500G>A; p.R167Q; 8:21910791-21910791	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1001_1002insT; p.E334fs*9; 8:21909548-21909549	ovary	carcinoma; serous_carcinoma	Insertion - Frameshift
c.649T>G; p.C217G; 8:21909901-21909901	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.598C>T; p.R200W; 8:21910693-21910693	prostate	carcinoma	Substitution - Missense
c.598C>T; p.R200W; 8:21910693-21910693	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.759C>A; p.P253P; 8:21909791-21909791	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.759C>A; p.P253P; 8:21909791-21909791	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.759C>A; p.P253P; 8:21909791-21909791	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.577G>A; p.D193N; 8:21910714-21910714	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.577G>A; p.D193N; 8:21910714-21910714	NS	malignant_melanoma	Substitution - Missense
c.1152C>A; p.V384V; 8:21909398-21909398	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.10G>T; p.G4W; 8:21913592-21913592	skin	malignant_melanoma	Substitution - Missense
c.1152C>A; p.V384V; 8:21909398-21909398	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.82G>A; p.A28T; 8:21912492-21912492	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.82G>A; p.A28T; 8:21912492-21912492	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.170G>A; p.R57Q; 8:21912404-21912404	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1090C>T; p.R364W; 8:21909460-21909460	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.847C>A; p.P283T; 8:21909703-21909703	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1140C>A; p.G380G; 8:21909410-21909410	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1009C>T; p.L337L; 8:21909541-21909541	skin	malignant_melanoma	Substitution - coding silent
c.17T>G; p.V6G; 8:21913585-21913585	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.659G>A; p.G220E; 8:21909891-21909891	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.84C>A; p.A28A; 8:21912490-21912490	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.447G>A; p.K149K; 8:21910844-21910844	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.447G>A; p.K149K; 8:21910844-21910844	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1083G>A; p.Q361Q; 8:21909467-21909467	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.499C>T; p.R167W; 8:21910792-21910792	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.499C>T; p.R167W; 8:21910792-21910792	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.53C>A; p.T18K; 8:21913549-21913549	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.149C>T; p.P50L; 8:21912425-21912425	skin	malignant_melanoma	Substitution - Missense
c.728C>G; p.S243C; 8:21909822-21909822	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.72C>A; p.R24R; 8:21912502-21912502	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.287C>T; p.A96V; 8:21912287-21912287	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.967C>G; p.Q323E; 8:21909583-21909583	urinary_tract; bladder	carcinoma	Substitution - Missense
c.271C>T; p.R91C; 8:21912303-21912303	breast	carcinoma	Substitution - Missense
c.1048G>T; p.G350*; 8:21909502-21909502	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.823C>T; p.H275Y; 8:21909727-21909727	breast	carcinoma	Substitution - Missense
c.519G>C; p.R173R; 8:21910772-21910772	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1189C>G; p.Q397E; 8:21909361-21909361	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1189C>G; p.Q397E; 8:21909361-21909361	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.576C>T; p.Y192Y; 8:21910715-21910715	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.955G>A; p.A319T; 8:21909595-21909595	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.990C>T; p.Y330Y; 8:21909560-21909560	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.640_641GG>TT; p.G214F; 8:21909909-21909910	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.590G>T; p.R197M; 8:21910701-21910701	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.611G>A; p.R204Q; 8:21910680-21910680	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.827A>T; p.D276V; 8:21909723-21909723	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1150G>T; p.V384F; 8:21909400-21909400	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.647G>A; p.R216H; 8:21909903-21909903	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.647G>A; p.R216H; 8:21909903-21909903	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1079C>G; p.P360R; 8:21909471-21909471	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation