lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	8797
Symbol	TNFRSF10A
Synonymous	APO2\|CD261\|DR4\|TRAILR-1\|TRAILR1
Full name	tumor necrosis factor receptor superfamily, member 10a
Gene description	TNF-related apoptosis-inducing ligand receptor 1\|TRAIL receptor 1\|TRAIL-R1\|cytotoxic TRAIL receptor\|death receptor 4\|tumor necrosis factor receptor superfamily member 10A\|tumor necrosis factor receptor superfamily member 10a variant 2
Cytoband	8p21
Gene type	protein-coding
Synonymous	MIM:603611; HGNC:HGNC:11904; HPRD:04679

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.23T>C; p.V8A; 8:23225039-23225039	oesophagus	carcinoma	Substitution - Missense
c.54G>C; p.P18P; 8:23225008-23225008	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1195G>A; p.A399T; 8:23191906-23191906	skin	malignant_melanoma	Substitution - Missense
c.945G>A; p.M315I; 8:23199335-23199335	skin	malignant_melanoma	Substitution - Missense
c.1263G>A; p.R421R; 8:23191838-23191838	skin	malignant_melanoma	Substitution - coding silent
c.1122C>T; p.I374I; 8:23191979-23191979	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1122C>T; p.I374I; 8:23191979-23191979	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1262G>A; p.R421Q; 8:23191839-23191839	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1326_1327delGA; p.K443fs*>26; 8:23191774-23191775	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1170G>A; p.T390T; 8:23191931-23191931	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1170G>A; p.T390T; 8:23191931-23191931	skin	malignant_melanoma	Substitution - coding silent
c.1170G>A; p.T390T; 8:23191931-23191931	skin	malignant_melanoma	Substitution - coding silent
c.1170G>A; p.T390T; 8:23191931-23191931	skin	malignant_melanoma	Substitution - coding silent
c.570C>G; p.C190W; 8:23201867-23201867	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.422A>G; p.H141R; 8:23202743-23202743	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.860G>A; p.R287Q; 8:23199420-23199420	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.860G>A; p.R287Q; 8:23199420-23199420	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.578G>A; p.G193E; 8:23201859-23201859	skin	malignant_melanoma	Substitution - Missense
c.340C>T; p.H114Y; 8:23212179-23212179	skin	malignant_melanoma	Substitution - Missense
c.594C>T; p.D198D; 8:23201843-23201843	skin	malignant_melanoma	Substitution - coding silent
c.1122C>A; p.I374I; 8:23191979-23191979	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1122C>A; p.I374I; 8:23191979-23191979	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.309C>T; p.V103V; 8:23212210-23212210	breast	carcinoma	Substitution - coding silent
c.1384G>A; p.G462S; 8:23191717-23191717	skin	malignant_melanoma	Substitution - Missense
c.969G>T; p.L323F; 8:23199311-23199311	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.378C>T; p.S126S; 8:23212141-23212141	skin; abdomen	malignant_melanoma	Substitution - coding silent
c.1327A>G; p.K443E; 8:23191774-23191774	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.681C>T; p.I227I; 8:23200709-23200709	skin	malignant_melanoma	Substitution - coding silent
c.681C>T; p.I227I; 8:23200709-23200709	skin	malignant_melanoma	Substitution - coding silent
c.682G>T; p.E228*; 8:23200708-23200708	skin	malignant_melanoma	Substitution - Nonsense
c.464C>T; p.T155I; 8:23202701-23202701	NS	malignant_melanoma	Substitution - Missense
c.440G>T; p.R147L; 8:23202725-23202725	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1218T>G; p.D406E; 8:23191883-23191883	skin	malignant_melanoma	Substitution - Missense
c.1218T>G; p.D406E; 8:23191883-23191883	skin	malignant_melanoma	Substitution - Missense
c.1035G>A; p.G345G; 8:23197184-23197184	skin	malignant_melanoma	Substitution - coding silent
c.337C>T; p.L113F; 8:23212182-23212182	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.683A>C; p.E228A; 8:23200707-23200707	skin	malignant_melanoma	Substitution - Missense
c.683A>C; p.E228A; 8:23200707-23200707	skin	malignant_melanoma	Substitution - Missense
c.683A>C; p.E228A; 8:23200707-23200707	thyroid	other; neoplasm	Substitution - Missense
c.645G>T; p.M215I; 8:23200745-23200745	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.352A>G; p.I118V; 8:23212167-23212167	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1132G>A; p.D378N; 8:23191969-23191969	urinary_tract; bladder	carcinoma	Substitution - Missense
c.96C>T; p.A32A; 8:23224966-23224966	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.990C>T; p.S330S; 8:23199290-23199290	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1019C>T; p.P340L; 8:23197200-23197200	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.894G>C; p.E298D; 8:23199386-23199386	urinary_tract; bladder	carcinoma	Substitution - Missense
c.439C>A; p.R147R; 8:23202726-23202726	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1328A>G; p.K443R; 8:23191773-23191773	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1328A>G; p.K443R; 8:23191773-23191773	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.757C>T; p.L253L; 8:23200547-23200547	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.546G>A; p.T182T; 8:23201891-23201891	skin	malignant_melanoma	Substitution - coding silent
c.1043G>A; p.R348K; 8:23197176-23197176	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1185T>C; p.D395D; 8:23191916-23191916	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.751C>T; p.P251S; 8:23200553-23200553	NS	malignant_melanoma	Substitution - Missense
c.845G>T; p.R282L; 8:23199435-23199435	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.874G>A; p.E292K; 8:23199406-23199406	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1369T>G; p.L457V; 8:23191732-23191732	skin	malignant_melanoma	Substitution - Missense
c.947A>G; p.E316G; 8:23199333-23199333	pancreas	carcinoma	Substitution - Missense
c.799G>T; p.G267C; 8:23200505-23200505	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.440G>A; p.R147Q; 8:23202725-23202725	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.914C>T; p.S305L; 8:23199366-23199366	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.395G>T; p.C132F; 8:23212124-23212124	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.14C>T; p.P5L; 8:23225048-23225048	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.665C>T; p.T222M; 8:23200725-23200725	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.840C>G; p.F280L; 8:23199440-23199440	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.840C>G; p.F280L; 8:23199440-23199440	urinary_tract; bladder	carcinoma	Substitution - Missense
c.989C>T; p.S330F; 8:23199291-23199291	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1236G>A; p.L412L; 8:23191865-23191865	skin	malignant_melanoma	Substitution - coding silent
c.95C>A; p.A32D; 8:23224967-23224967	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.844C>T; p.R282C; 8:23199436-23199436	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.425C>A; p.P142H; 8:23202740-23202740	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1215G>A; p.G405G; 8:23191886-23191886	skin	malignant_melanoma	Substitution - coding silent
c.498A>G; p.P166P; 8:23202667-23202667	stomach	adenocarcinoma	Substitution - coding silent
c.1037C>G; p.S346C; 8:23197182-23197182	oesophagus	carcinoma	Substitution - Missense
c.1177G>A; p.E393K; 8:23191924-23191924	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1177G>A; p.E393K; 8:23191924-23191924	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1083T>C; p.T361T; 8:23197136-23197136	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.626G>C; p.R209T; 8:23201811-23201811	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.626G>C; p.R209T; 8:23201811-23201811	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.626G>C; p.R209T; 8:23201811-23201811	thyroid	other; neoplasm	Substitution - Missense
c.1004A>G; p.Q335R; 8:23199276-23199276	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.580A>G; p.T194A; 8:23201857-23201857	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.862G>T; p.G288W; 8:23199418-23199418	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.753G>A; p.P251P; 8:23200551-23200551	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.709G>T; p.G237*; 8:23200595-23200595	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.801T>C; p.G267G; 8:23199916-23199916	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.385G>A; p.G129R; 8:23212134-23212134	skin	malignant_melanoma	Substitution - Missense
c.295G>T; p.V99F; 8:23224767-23224767	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.187G>A; p.G63R; 8:23224875-23224875	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.933_934delTG; p.E312fs*32; 8:23199346-23199347	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.702A>G; p.S234S; 8:23200688-23200688	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation