Cancer metastasis database

Annotation category 5

Gene information

Gene ID 8795
Symbol

TNFRSF10B

Synonymous

CD262|DR5|KILLER|KILLER/DR5|TRAIL-R2|TRAILR2|TRICK2|TRICK2A|TRICK2B|TRICKB|ZTNFR9

Full name

tumor necrosis factor receptor superfamily, member 10b

Gene description

Fas-like protein|TNF receptor superfamily member 10b|TNF-related apoptosis-inducing ligand receptor 2|apoptosis inducing protein TRICK2A/2B|apoptosis inducing receptor TRAIL-R2|cytotoxic TRAIL receptor-2|death domain containing receptor for TRAIL/Apo-2L|d

Cytoband

8p22-p21

Gene type

protein-coding

Synonymous

MIM:603612; HGNC:HGNC:11905; Ensembl:ENSG00000120889; HPRD:04680; Vega:OTTHUMG00000097826

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.470G>A; p.R157H; 8:23029616-23029616

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.544G>T; p.E182*; 8:23028535-23028535

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.544G>T; p.E182*; 8:23028535-23028535

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.803A>G; p.E268G; 8:23027266-23027266

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.231A>G; p.S77S; 8:23043157-23043157

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.766G>A; p.E256K; 8:23027736-23027736

 livercarcinomaSubstitution - Missense

c.1181G>T; p.G394V; 8:23022813-23022813

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.939A>T; p.E313D; 8:23024258-23024258

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.766G>A; p.E256K; 8:23027736-23027736

 livercarcinomaSubstitution - Missense

c.1180G>A; p.G394R; 8:23022814-23022814

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.640A>G; p.I214V; 8:23028439-23028439

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.1027G>T; p.D343Y; 8:23022967-23022967

 pancreascarcinomaSubstitution - Missense

c.271G>A; p.G91S; 8:23030852-23030852

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.529G>A; p.E177K; 8:23028550-23028550

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.23C>A; p.A8D; 8:23068872-23068872

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.982C>T; p.P328S; 8:23024215-23024215

 skinmalignant_melanomaSubstitution - Missense

c.476+1G>T; p.?; 8:23029609-23029609

 lungcarcinoma; squamous_cell_carcinomaUnknown

c.825C>G; p.I275M; 8:23027244-23027244

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.923C>T; p.S308L; 8:23027146-23027146

 stomachadenocarcinomaSubstitution - Missense

c.205C>T; p.P69S; 8:23043183-23043183

 skin; neckmalignant_melanomaSubstitution - Missense

c.174A>T; p.Q58H; 8:23043214-23043214

 boneEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - Missense

c.921G>C; p.E307D; 8:23027148-23027148

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.281G>A; p.C94Y; 8:23030842-23030842

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.919G>A; p.E307K; 8:23027150-23027150

 skinmalignant_melanomaSubstitution - Missense

c.38G>A; p.G13E; 8:23068857-23068857

 skinmalignant_melanomaSubstitution - Missense

c.461G>A; p.R154Q; 8:23029625-23029625

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.290G>A; p.C97Y; 8:23030833-23030833

 NSNSSubstitution - Missense

c.791G>A; p.R264Q; 8:23027278-23027278

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.914C>T; p.P305L; 8:23027155-23027155

 skinmalignant_melanomaSubstitution - Missense

c.914C>T; p.P305L; 8:23027155-23027155

 skinmalignant_melanomaSubstitution - Missense

c.22G>T; p.A8S; 8:23068873-23068873

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.649G>T; p.G217*; 8:23028430-23028430

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1314C>A; p.A438A; 8:23022680-23022680

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.528C>T; p.I176I; 8:23028551-23028551

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.144+2T>C; p.?; 8:23068749-23068749

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.985G>T; p.A329S; 8:23024212-23024212

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1030G>T; p.D344Y; 8:23022964-23022964

 breastcarcinomaSubstitution - Missense

c.1113T>C; p.A371A; 8:23022881-23022881

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1269G>C; p.L423F; 8:23022725-23022725

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.250+2T>C; p.?; 8:23043136-23043136

 stomachcarcinoma; adenocarcinomaUnknown

c.20A>G; p.N7S; 8:23068875-23068875

 pancreascarcinomaSubstitution - Missense

c.1164G>C; p.K388N; 8:23022830-23022830

 pancreascarcinomaSubstitution - Missense

c.298G>T; p.G100*; 8:23030825-23030825

 livercarcinomaSubstitution - Nonsense

c.344G>A; p.R115H; 8:23030779-23030779

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.591G>A; p.T197T; 8:23028488-23028488

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.226C>T; p.P76S; 8:23043162-23043162

 skin; extremitymalignant_melanomaSubstitution - Missense

c.746C>T; p.S249L; 8:23028333-23028333

 skinmalignant_melanomaSubstitution - Missense

c.382C>T; p.P128S; 8:23029704-23029704

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.418G>A; p.E140K; 8:23029668-23029668

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.463A>G; p.K155E; 8:23029623-23029623

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.820G>T; p.E274*; 8:23027249-23027249

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1181G>A; p.G394E; 8:23022813-23022813

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.1010-1G>C; p.?; 8:23022985-23022985

 livercarcinoma; hepatocellular_carcinomaUnknown

c.25C>A; p.P9T; 8:23068870-23068870

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1252A>C; p.I418L; 8:23022742-23022742

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.825C>T; p.I275I; 8:23027244-23027244

 skinmalignant_melanomaSubstitution - coding silent

c.248C>T; p.P83L; 8:23043140-23043140

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1047G>T; p.V349V; 8:23022947-23022947

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1131C>A; p.G377G; 8:23022863-23022863

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.763C>A; p.P255T; 8:23027739-23027739

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense