Cancer metastasis database

Annotation category 5

Gene information

Gene ID 8678
Symbol

BECN1

Synonymous

ATG6|VPS30|beclin1

Full name

beclin 1, autophagy related

Gene description

ATG6 autophagy related 6 homolog|beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)|beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)|beclin-1|coiled-coil myosin-like BCL2-interacting protein

Cytoband

17q21

Gene type

protein-coding

Synonymous

MIM:604378; HGNC:HGNC:1034; Ensembl:ENSG00000126581; HPRD:05087; Vega:OTTHUMG00000180653

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.365T>C; p.L122P; 17:42818667-42818667

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.720G>C; p.Q240H; 17:42816018-42816018

 central_nervous_system; medullaglioma; oligodendroglioma_Grade_IIISubstitution - Missense

c.1091A>G; p.K364R; 17:42811748-42811748

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.38A>G; p.Q13R; 17:42823840-42823840

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.358G>T; p.G120W; 17:42818674-42818674

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.542A>G; p.Q181R; 17:42818362-42818362

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemia_therapy_relatedSubstitution - Missense

c.542A>G; p.Q181R; 17:42818362-42818362

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.375_377delCAT; p.I125delI; 17:42818655-42818657

 livercarcinomaDeletion - In frame

c.999C>T; p.Y333Y; 17:42813990-42813990

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.224A>T; p.Q75L; 17:42819584-42819584

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.784G>T; p.D262Y; 17:42815954-42815954

 thyroidcarcinomaSubstitution - Missense

c.558G>A; p.E186E; 17:42818346-42818346

 pancreascarcinoma; ductal_carcinomaSubstitution - coding silent

c.292A>C; p.T98P; 17:42818846-42818846

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.294T>G; p.T98T; 17:42818844-42818844

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1133A>G; p.Q378R; 17:42811706-42811706

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.494G>T; p.C165F; 17:42818410-42818410

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1041G>C; p.K347N; 17:42813948-42813948

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.14A>G; p.K5R; 17:42823864-42823864

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.405A>G; p.P135P; 17:42818627-42818627

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1042-3C>G; p.?; 17:42811800-42811800

 livercarcinomaUnknown

c.1159G>A; p.E387K; 17:42811680-42811680

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1092G>C; p.K364N; 17:42811747-42811747

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1092G>C; p.K364N; 17:42811747-42811747

 pancreascarcinomaSubstitution - Missense

c.1000G>A; p.G334R; 17:42813989-42813989

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.804C>T; p.N268N; 17:42815934-42815934

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.676G>T; p.E226*; 17:42818228-42818228

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.424G>C; p.D142H; 17:42818608-42818608

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.75G>A; p.L25L; 17:42823803-42823803

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.918T>C; p.A306A; 17:42814586-42814586

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.412G>A; p.E138K; 17:42818620-42818620

 skinmalignant_melanomaSubstitution - Missense

c.59G>A; p.R20H; 17:42823819-42823819

 kidneyother; neoplasmSubstitution - Missense

c.1120G>T; p.D374Y; 17:42811719-42811719

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.318C>T; p.G106G; 17:42818820-42818820

 oesophaguscarcinomaSubstitution - coding silent

c.1324T>C; p.W442R; 17:42810789-42810789

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.251C>T; p.P84L; 17:42819557-42819557

 skinmalignant_melanomaSubstitution - Missense

c.995C>T; p.P332L; 17:42813994-42813994

 skinmalignant_melanomaSubstitution - Missense

c.995C>T; p.P332L; 17:42813994-42813994

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1313G>T; p.W438L; 17:42810800-42810800

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.133C>G; p.P45A; 17:42820839-42820839

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.133C>G; p.P45A; 17:42820839-42820839

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.238C>T; p.R80C; 17:42819570-42819570

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1214A>G; p.D405G; 17:42810899-42810899

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.93C>G; p.F31L; 17:42823785-42823785

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.459C>T; p.N153N; 17:42818573-42818573

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.694G>T; p.E232*; 17:42816044-42816044

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.859A>G; p.N287D; 17:42814645-42814645

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.927G>C; p.Q309H; 17:42814577-42814577

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.609G>A; p.K203K; 17:42818295-42818295

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.962T>C; p.M321T; 17:42814542-42814542

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.684-2A>C; p.?; 17:42816056-42816056

 livercarcinomaUnknown

c.199G>A; p.E67K; 17:42819609-42819609

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.199G>A; p.E67K; 17:42819609-42819609

 skin; trunkmalignant_melanomaSubstitution - Missense