lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	8434
Symbol	RECK
Synonymous	ST15
Full name	reversion-inducing-cysteine-rich protein with kazal motifs
Gene description	membrane-anchored glycoprotein (metastasis and invasion)\|reversion-inducing cysteine-rich protein with Kazal motifs\|suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)\|suppression of tumorigenicity 5 (reversion-in
Cytoband	9p13.3
Gene type	protein-coding
Synonymous	MIM:605227; HGNC:HGNC:11345; Ensembl:ENSG00000122707; HPRD:05567; Vega:OTTHUMG00000019898

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.2528C>A; p.T843N; 9:36120726-36120726	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2462C>G; p.P821R; 9:36118965-36118965	thyroid	carcinoma	Substitution - Missense
c.185G>A; p.R62Q; 9:36058852-36058852	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2031T>C; p.C677C; 9:36112447-36112447	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1086-1G>T; p.?; 9:36100330-36100330	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.1779C>A; p.S593S; 9:36109970-36109970	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.340C>T; p.R114*; 9:36063863-36063863	breast	carcinoma	Substitution - Nonsense
c.1935G>C; p.Q645H; 9:36112351-36112351	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2278G>A; p.V760I; 9:36118781-36118781	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1526G>A; p.R509Q; 9:36105233-36105233	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1526G>A; p.R509Q; 9:36105233-36105233	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.817C>T; p.P273S; 9:36087873-36087873	thyroid	other; neoplasm	Substitution - Missense
c.2579A>G; p.Q860R; 9:36121573-36121573	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1431C>A; p.Y477*; 9:36102226-36102226	central_nervous_system; brain	glioma	Substitution - Nonsense
c.755C>T; p.T252I; 9:36087811-36087811	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.160-1G>T; p.?; 9:36058826-36058826	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.210C>T; p.A70A; 9:36058877-36058877	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.263C>G; p.S88C; 9:36060147-36060147	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1538C>T; p.P513L; 9:36105245-36105245	skin	malignant_melanoma	Substitution - Missense
c.1882T>C; p.F628L; 9:36110073-36110073	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.263C>G; p.S88C; 9:36060147-36060147	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2785C>G; p.L929V; 9:36122914-36122914	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.2452A>C; p.I818L; 9:36118955-36118955	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2142C>T; p.L714L; 9:36117066-36117066	skin	malignant_melanoma	Substitution - coding silent
c.2463G>A; p.P821P; 9:36118966-36118966	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.929G>A; p.S310N; 9:36091187-36091187	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.559T>G; p.C187G; 9:36083484-36083484	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2655C>T; p.I885I; 9:36121649-36121649	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.561C>T; p.C187C; 9:36083486-36083486	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2667C>T; p.P889P; 9:36121661-36121661	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1347C>T; p.F449F; 9:36102142-36102142	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1093G>T; p.E365*; 9:36100338-36100338	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1093G>T; p.E365*; 9:36100338-36100338	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1320_1321insA; p.C443fs*9; 9:36102115-36102116	skin; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.268C>T; p.P90S; 9:36060152-36060152	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2127T>C; p.C709C; 9:36117051-36117051	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2255C>T; p.P752L; 9:36118758-36118758	skin	malignant_melanoma	Substitution - Missense
c.2145G>A; p.A715A; 9:36117069-36117069	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2332C>T; p.R778C; 9:36118835-36118835	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.708G>T; p.K236N; 9:36087764-36087764	breast	carcinoma	Substitution - Missense
c.1064_1067delACTG; p.Y355fs*24; 9:36091322-36091325	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1933C>T; p.Q645*; 9:36112349-36112349	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.1086G>A; p.R362R; 9:36100331-36100331	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1129G>A; p.G377R; 9:36100374-36100374	skin; abdomen	malignant_melanoma	Substitution - Missense
c.2539G>T; p.V847L; 9:36121533-36121533	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.406-1G>A; p.?; 9:36080604-36080604	skin	malignant_melanoma	Unknown
c.1417C>T; p.P473S; 9:36102212-36102212	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1366G>A; p.E456K; 9:36102161-36102161	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1373T>A; p.I458N; 9:36102168-36102168	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2318C>T; p.A773V; 9:36118821-36118821	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2318C>T; p.A773V; 9:36118821-36118821	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1875T>A; p.R625R; 9:36110066-36110066	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2562A>G; p.T854T; 9:36121556-36121556	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2826G>T; p.S942S; 9:36122955-36122955	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2562A>G; p.T854T; 9:36121556-36121556	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1875T>A; p.R625R; 9:36110066-36110066	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1766-1G>T; p.?; 9:36109956-36109956	lung	carcinoma; adenocarcinoma	Unknown
c.2152C>T; p.Q718*; 9:36117076-36117076	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.2272G>A; p.E758K; 9:36118775-36118775	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1560A>G; p.P520P; 9:36105267-36105267	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1852G>A; p.E618K; 9:36110043-36110043	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1560A>G; p.P520P; 9:36105267-36105267	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1613G>A; p.R538H; 9:36108012-36108012	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1613G>A; p.R538H; 9:36108012-36108012	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2772C>T; p.V924V; 9:36122901-36122901	skin	malignant_melanoma	Substitution - coding silent
c.347C>T; p.A116V; 9:36063870-36063870	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2564T>G; p.V855G; 9:36121558-36121558	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2200C>T; p.L734F; 9:36117124-36117124	skin	malignant_melanoma	Substitution - Missense
c.2143G>A; p.A715T; 9:36117067-36117067	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2143G>A; p.A715T; 9:36117067-36117067	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1185C>T; p.I395I; 9:36100430-36100430	skin	malignant_melanoma	Substitution - coding silent
c.2222G>T; p.G741V; 9:36117146-36117146	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1533A>G; p.G511G; 9:36105240-36105240	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2794T>G; p.S932A; 9:36122923-36122923	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2149G>C; p.D717H; 9:36117073-36117073	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2149G>C; p.D717H; 9:36117073-36117073	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1277C>A; p.S426Y; 9:36100522-36100522	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2520A>C; p.K840N; 9:36120718-36120718	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2671G>A; p.D891N; 9:36121665-36121665	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1002C>T; p.S334S; 9:36091260-36091260	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1002C>T; p.S334S; 9:36091260-36091260	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2671G>A; p.D891N; 9:36121665-36121665	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.577C>T; p.Q193*; 9:36083502-36083502	ovary	carcinoma	Substitution - Nonsense
c.2310T>G; p.S770R; 9:36118813-36118813	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1970G>A; p.R657H; 9:36112386-36112386	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.248A>G; p.N83S; 9:36060132-36060132	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.509G>A; p.R170Q; 9:36083434-36083434	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2393C>T; p.S798F; 9:36118896-36118896	skin	malignant_melanoma	Substitution - Missense
c.1838G>A; p.R613H; 9:36110029-36110029	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2294G>T; p.G765V; 9:36118797-36118797	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1655T>C; p.V552A; 9:36108054-36108054	skin	malignant_melanoma	Substitution - Missense
c.2184C>T; p.H728H; 9:36117108-36117108	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.616C>T; p.P206S; 9:36083541-36083541	skin	malignant_melanoma	Substitution - Missense
c.2394C>G; p.S798S; 9:36118897-36118897	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.500C>T; p.A167V; 9:36083425-36083425	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2161G>C; p.D721H; 9:36117085-36117085	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.2161G>C; p.D721H; 9:36117085-36117085	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2279T>A; p.V760E; 9:36118782-36118782	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1994A>T; p.Q665L; 9:36112410-36112410	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.524C>T; p.P175L; 9:36083449-36083449	skin	malignant_melanoma	Substitution - Missense
c.823G>C; p.V275L; 9:36087879-36087879	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.551A>G; p.E184G; 9:36083476-36083476	skin	malignant_melanoma	Substitution - Missense
c.2775T>C; p.P925P; 9:36122904-36122904	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2096T>C; p.F699S; 9:36117020-36117020	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.544G>A; p.A182T; 9:36083469-36083469	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.544G>A; p.A182T; 9:36083469-36083469	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.544G>A; p.A182T; 9:36083469-36083469	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1494_1496delTTG; p.C499delC; 9:36105201-36105203	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - In frame
c.1494_1496delTTG; p.C499delC; 9:36105201-36105203	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - In frame
c.1494_1496delTTG; p.C499delC; 9:36105201-36105203	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - In frame
c.2596G>A; p.V866M; 9:36121590-36121590	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2662A>G; p.I888V; 9:36121656-36121656	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1955G>A; p.S652N; 9:36112371-36112371	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1588G>A; p.G530R; 9:36107987-36107987	liver	carcinoma	Substitution - Missense
c.1019C>A; p.A340E; 9:36091277-36091277	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1311G>T; p.V437V; 9:36102106-36102106	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2777T>A; p.L926H; 9:36122906-36122906	skin	malignant_melanoma	Substitution - Missense
c.517T>A; p.S173T; 9:36083442-36083442	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.725T>C; p.I242T; 9:36087781-36087781	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.184C>A; p.R62R; 9:36058851-36058851	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.953G>T; p.S318I; 9:36091211-36091211	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.850G>T; p.G284C; 9:36087906-36087906	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.840T>C; p.P280P; 9:36087896-36087896	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2416A>G; p.K806E; 9:36118919-36118919	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1354G>A; p.D452N; 9:36102149-36102149	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2109A>T; p.G703G; 9:36117033-36117033	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.816C>A; p.H272Q; 9:36087872-36087872	thyroid	other; neoplasm	Substitution - Missense
c.562G>A; p.A188T; 9:36083487-36083487	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.2534C>T; p.A845V; 9:36120732-36120732	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2595C>T; p.H865H; 9:36121589-36121589	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.775C>T; p.P259S; 9:36087831-36087831	skin	malignant_melanoma	Substitution - Missense
c.322G>C; p.A108P; 9:36063845-36063845	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1313A>T; p.E438V; 9:36102108-36102108	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2587C>T; p.R863C; 9:36121581-36121581	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2370C>T; p.V790V; 9:36118873-36118873	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1837C>G; p.R613G; 9:36110028-36110028	skin	malignant_melanoma	Substitution - Missense
c.1770T>A; p.H590Q; 9:36109961-36109961	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1766-7C>A; p.?; 9:36109950-36109950	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.741C>T; p.I247I; 9:36087797-36087797	skin	malignant_melanoma	Substitution - coding silent
c.2154G>T; p.Q718H; 9:36117078-36117078	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2048delA; p.N685fs*12; 9:36112464-36112464	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2048delA; p.N685fs*12; 9:36112464-36112464	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2048delA; p.N685fs*12; 9:36112464-36112464	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2308_2309insGT; p.A773fs*61; 9:36118811-36118812	endometrium	carcinoma; endometrioid_carcinoma	Insertion - Frameshift
c.2048delA; p.N685fs*12; 9:36112464-36112464	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1057_1060delCTTA; p.Y355fs*24; 9:36091315-36091318	endometrium	carcinoma; endometrioid_carcinoma	Deletion - Frameshift
c.2503T>G; p.L835V; 9:36120701-36120701	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.817C>A; p.P273T; 9:36087873-36087873	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2398G>T; p.A800S; 9:36118901-36118901	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2670C>T; p.V890V; 9:36121664-36121664	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2015T>C; p.M672T; 9:36112431-36112431	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2670C>T; p.V890V; 9:36121664-36121664	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.147T>C; p.D49D; 9:36052311-36052311	breast	carcinoma	Substitution - coding silent
c.950_951delAG; p.S318fs*5; 9:36091208-36091209	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.815A>G; p.H272R; 9:36087871-36087871	thyroid	other; neoplasm	Substitution - Missense
c.316G>A; p.E106K; 9:36063839-36063839	pancreas	carcinoma	Substitution - Missense
c.316G>A; p.E106K; 9:36063839-36063839	pancreas	carcinoma	Substitution - Missense
c.1197T>G; p.V399V; 9:36100442-36100442	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1371T>C; p.S457S; 9:36102166-36102166	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.459T>C; p.S153S; 9:36083384-36083384	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1731C>T; p.L577L; 9:36108130-36108130	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2409T>G; p.A803A; 9:36118912-36118912	liver	carcinoma	Substitution - coding silent
c.1351G>A; p.E451K; 9:36102146-36102146	skin	malignant_melanoma	Substitution - Missense
c.514G>C; p.D172H; 9:36083439-36083439	skin	malignant_melanoma	Substitution - Missense
c.778C>T; p.L260F; 9:36087834-36087834	skin; abdomen	malignant_melanoma	Substitution - Missense
c.809C>T; p.S270F; 9:36087865-36087865	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1291A>G; p.I431V; 9:36100536-36100536	breast	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation