lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	7066
Symbol	THPO
Synonymous	MGDF\|MKCSF\|ML\|MPLLG\|THCYT1\|TPO
Full name	thrombopoietin
Gene description	MPL ligand\|c-mpl ligand\|megakaryocyte colony-stimulating factor\|megakaryocyte growth and development factor\|megakaryocyte stimulating factor\|myeloproliferative leukemia virus oncogene ligand\|prepro-thrombopoietin
Cytoband	3q27
Gene type	protein-coding
Synonymous	MIM:600044; HGNC:HGNC:11795; Ensembl:ENSG00000090534; HPRD:02500; Vega:OTTHUMG00000156745

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.992C>T; p.T331M; 3:184372583-184372583	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.92G>A; p.R31Q; 3:184375937-184375937	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.816G>T; p.P272P; 3:184372759-184372759	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.754G>A; p.E252K; 3:184372821-184372821	skin	malignant_melanoma	Substitution - Missense
c.754G>A; p.E252K; 3:184372821-184372821	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.967delC; p.L323fs*17; 3:184372608-184372608	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.754G>A; p.E252K; 3:184372821-184372821	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.754G>A; p.E252K; 3:184372821-184372821	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.803C>T; p.T268I; 3:184372772-184372772	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.307G>A; p.G103R; 3:184373504-184373504	skin	malignant_melanoma	Substitution - Missense
c.497T>C; p.V166A; 3:184373078-184373078	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1012C>T; p.L338F; 3:184372563-184372563	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.944C>T; p.T315I; 3:184372631-184372631	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.850C>A; p.L284M; 3:184372725-184372725	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.767G>T; p.G256V; 3:184372808-184372808	urinary_tract; bladder	carcinoma	Substitution - Missense
c.231G>A; p.E77E; 3:184373580-184373580	skin	malignant_melanoma	Substitution - coding silent
c.794C>T; p.S265L; 3:184372781-184372781	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.496G>A; p.V166I; 3:184373079-184373079	prostate	carcinoma	Substitution - Missense
c.684G>T; p.K228N; 3:184372891-184372891	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.776G>A; p.G259E; 3:184372799-184372799	skin	malignant_melanoma	Substitution - Missense
c.776G>A; p.G259E; 3:184372799-184372799	skin	malignant_melanoma	Substitution - Missense
c.930A>G; p.P310P; 3:184372645-184372645	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.988C>T; p.P330S; 3:184372587-184372587	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.988C>T; p.P330S; 3:184372587-184372587	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.884C>T; p.S295F; 3:184372691-184372691	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.323C>T; p.S108L; 3:184373488-184373488	breast	carcinoma	Substitution - Missense
c.1041G>T; p.Q347H; 3:184372534-184372534	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.360C>T; p.L120L; 3:184373451-184373451	skin	malignant_melanoma	Substitution - coding silent
c.128T>G; p.L43R; 3:184375901-184375901	thyroid	carcinoma	Substitution - Missense
c.470G>A; p.R157Q; 3:184373105-184373105	skin	malignant_melanoma	Substitution - Missense
c.250A>C; p.I84L; 3:184373561-184373561	skin	malignant_melanoma	Substitution - Missense
c.1049C>G; p.S350C; 3:184372526-184372526	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.680C>G; p.A227G; 3:184372895-184372895	thyroid	carcinoma	Substitution - Missense
c.19C>T; p.L7F; 3:184376010-184376010	liver	carcinoma	Substitution - Missense
c.157G>A; p.V53I; 3:184375586-184375586	skin	malignant_melanoma	Substitution - Missense
c.19C>T; p.L7F; 3:184376010-184376010	liver	carcinoma	Substitution - Missense
c.528C>A; p.A176A; 3:184373047-184373047	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.904G>T; p.G302*; 3:184372671-184372671	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.632C>T; p.A211V; 3:184372943-184372943	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.632C>T; p.A211V; 3:184372943-184372943	stomach	adenocarcinoma	Substitution - Missense
c.61T>A; p.S21T; 3:184375968-184375968	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.755A>G; p.E252G; 3:184372820-184372820	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.769A>G; p.T257A; 3:184372806-184372806	skin	malignant_melanoma	Substitution - Missense
c.912T>C; p.Y304Y; 3:184372663-184372663	liver	carcinoma	Substitution - coding silent
c.912T>C; p.Y304Y; 3:184372663-184372663	liver	carcinoma	Substitution - coding silent
c.827C>T; p.S276L; 3:184372748-184372748	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.964C>T; p.P322S; 3:184372611-184372611	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.670G>A; p.G224R; 3:184372905-184372905	skin	malignant_melanoma	Substitution - Missense
c.68C>T; p.P23L; 3:184375961-184375961	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.914C>T; p.T305M; 3:184372661-184372661	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.56C>T; p.T19M; 3:184375973-184375973	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.897T>C; p.P299P; 3:184372678-184372678	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.112C>T; p.R38C; 3:184375917-184375917	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.593G>T; p.R198M; 3:184372982-184372982	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4G>A; p.E2K; 3:184376256-184376256	skin	malignant_melanoma	Substitution - Missense
c.533C>T; p.P178L; 3:184373042-184373042	NS	malignant_melanoma	Substitution - Missense
c.533C>T; p.P178L; 3:184373042-184373042	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.113G>A; p.R38H; 3:184375916-184375916	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.299G>A; p.G100E; 3:184373512-184373512	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.113G>A; p.R38H; 3:184375916-184375916	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.923C>T; p.P308L; 3:184372652-184372652	skin	malignant_melanoma	Substitution - Missense
c.732C>A; p.P244P; 3:184372843-184372843	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.842C>T; p.T281I; 3:184372733-184372733	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.523C>T; p.R175W; 3:184373052-184373052	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.523C>T; p.R175W; 3:184373052-184373052	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.728T>G; p.I243S; 3:184372847-184372847	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.130C>T; p.H44Y; 3:184375899-184375899	NS	NS	Substitution - Missense
c.941C>A; p.P314H; 3:184372634-184372634	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.896C>T; p.P299L; 3:184372679-184372679	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.481C>T; p.R161C; 3:184373094-184373094	breast	carcinoma	Substitution - Missense
c.584T>C; p.L195P; 3:184372991-184372991	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.584T>C; p.L195P; 3:184372991-184372991	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.914C>G; p.T305R; 3:184372661-184372661	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.584T>C; p.L195P; 3:184372991-184372991	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.558C>A; p.T186T; 3:184373017-184373017	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.797G>A; p.R266H; 3:184372778-184372778	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.255G>A; p.L85L; 3:184373556-184373556	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.275T>C; p.L92P; 3:184373536-184373536	ovary	other; neoplasm	Substitution - Missense
c.791C>T; p.P264L; 3:184372784-184372784	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.648T>G; p.S216S; 3:184372927-184372927	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.385delC; p.G130fs*21; 3:184373426-184373426	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.826T>C; p.S276P; 3:184372749-184372749	stomach	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation