lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5770
Symbol	PTPN1
Synonymous	PTP1B
Full name	protein tyrosine phosphatase, non-receptor type 1
Gene description	protein tyrosine phosphatase, placental\|protein-tyrosine phosphatase 1B\|tyrosine-protein phosphatase non-receptor type 1
Cytoband	20q13.1-q13.2
Gene type	protein-coding
Synonymous	MIM:176885; HGNC:HGNC:9642; Ensembl:ENSG00000196396; HPRD:01477; Vega:OTTHUMG00000032729

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.909C>T; p.P303P; 20:50579747-50579747	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.909C>T; p.P303P; 20:50579747-50579747	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.909C>T; p.P303P; 20:50579747-50579747	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.656T>C; p.I219T; 20:50578583-50578583	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.803G>A; p.R268H; 20:50579268-50579268	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.467G>A; p.R156Q; 20:50574629-50574629	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1157C>T; p.S386F; 20:50581333-50581333	skin	malignant_melanoma	Substitution - Missense
c.136T>C; p.Y46H; 20:50561435-50561435	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1270T>C; p.Y424H; 20:50581446-50581446	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.649G>A; p.A217T; 20:50578576-50578576	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1068_1069insT; p.A357fs*13; 20:50579906-50579907	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1190A>G; p.K397R; 20:50581366-50581366	liver	carcinoma	Substitution - Missense
c.1128G>A; p.G376G; 20:50581304-50581304	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.205G>A; p.A69T; 20:50565019-50565019	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1155C>T; p.A385A; 20:50581331-50581331	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1175C>T; p.P392L; 20:50581351-50581351	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.142G>T; p.D48Y; 20:50561441-50561441	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1095T>G; p.S365R; 20:50581271-50581271	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1247C>T; p.A416V; 20:50581423-50581423	skin; trunk	malignant_melanoma	Substitution - Missense
c.592G>T; p.V198F; 20:50578519-50578519	liver	carcinoma	Substitution - Missense
c.94T>G; p.C32G; 20:50561393-50561393	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.553C>T; p.P185S; 20:50578480-50578480	skin	malignant_melanoma	Substitution - Missense
c.592G>T; p.V198F; 20:50578519-50578519	liver	carcinoma	Substitution - Missense
c.1116T>C; p.S372S; 20:50581292-50581292	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.8T>C; p.M3T; 20:50510535-50510535	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.399G>T; p.M133I; 20:50574561-50574561	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.944G>A; p.R315Q; 20:50579782-50579782	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1051G>T; p.G351*; 20:50579889-50579889	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.276C>T; p.C92C; 20:50568400-50568400	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1263C>T; p.A421A; 20:50581439-50581439	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.898G>A; p.E300K; 20:50579736-50579736	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.64G>T; p.D22Y; 20:50561363-50561363	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.535T>C; p.W179R; 20:50578462-50578462	thyroid	other; neoplasm	Substitution - Missense
c.1250C>T; p.T417M; 20:50581426-50581426	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1099G>C; p.D367H; 20:50581275-50581275	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1185C>T; p.P395P; 20:50581361-50581361	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1147C>T; p.Q383*; 20:50581323-50581323	skin	malignant_melanoma	Substitution - Nonsense
c.1090A>G; p.M364V; 20:50581266-50581266	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.805T>G; p.F269V; 20:50579270-50579270	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1129G>A; p.G377R; 20:50581305-50581305	skin	malignant_melanoma	Substitution - Missense
c.777G>A; p.G259G; 20:50579242-50579242	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.943C>T; p.R315*; 20:50579781-50579781	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1027G>A; p.D343N; 20:50579865-50579865	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.809C>T; p.S270F; 20:50579274-50579274	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.191A>T; p.N64I; 20:50565005-50565005	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1106A>C; p.E369A; 20:50581282-50581282	liver	carcinoma	Substitution - Missense
c.659G>A; p.G220D; 20:50578586-50578586	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.840C>T; p.F280F; 20:50579305-50579305	skin	malignant_melanoma	Substitution - coding silent
c.591A>G; p.K197K; 20:50578518-50578518	liver	carcinoma	Substitution - coding silent
c.591A>G; p.K197K; 20:50578518-50578518	liver	carcinoma	Substitution - coding silent
c.691T>G; p.C231G; 20:50578618-50578618	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1167A>T; p.K389N; 20:50581343-50581343	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.774G>T; p.M258I; 20:50579239-50579239	skin	malignant_melanoma	Substitution - Missense
c.1267G>A; p.A423T; 20:50581443-50581443	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1084G>A; p.E362K; 20:50579922-50579922	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.675C>T; p.F225F; 20:50578602-50578602	skin	malignant_melanoma	Substitution - coding silent
c.998G>A; p.W333*; 20:50579836-50579836	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; peripheral_T_cell_lymphoma_unspecified	Substitution - Nonsense
c.1138C>T; p.R380*; 20:50581314-50581314	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1138C>T; p.R380*; 20:50581314-50581314	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1125delG; p.G377fs*27; 20:50581301-50581301	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1125delG; p.G377fs*27; 20:50581301-50581301	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.769C>T; p.R257W; 20:50579234-50579234	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.769C>T; p.R257W; 20:50579234-50579234	skin	malignant_melanoma	Substitution - Missense
c.466C>T; p.R156*; 20:50574628-50574628	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.127C>T; p.R43*; 20:50561426-50561426	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.641A>C; p.H214P; 20:50578568-50578568	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.259C>G; p.P87A; 20:50568383-50568383	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1099G>T; p.D367Y; 20:50581275-50581275	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation