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Cancer metastasis database

Annotation category 5

Expression and regulation

Regulation From TransFac database

PTP1B(h) + Cas(h) <==> PTP1B(h):Cas(h) (binding)
PTP1B(h) --calpain-1(h)--> protein remnants + PTP1B-p42(h) (cleavage)
PTP1B(h) --calpain-2(h)--> protein remnants + PTP1B-p42(h) (cleavage)
Trpv6(r) + PTP1B(h) <==> Trpv6(r):PTP1B(h) (binding)
PTP1B(h) + ATP --Cdk1(m.s.)--> PTP1B(h){pS386} + ADP (phosphorylation)
PTP1B(h) + ATP --PKC(v.s.)--> PTP1B(h){pS378} + ADP (phosphorylation)
PTP1B(h) + ATP --AKT-1(m)--> PTP1B(h){pS50} + ADP (phosphorylation)
PTP1B(h) + InsR(h){pY} <==> PTP1B(h):InsR(h){pY} (binding)
PTP1B(h) + LAT(h){p} --> PTP1B(h):LAT(h) + p (dephosphorylation; binding)
PTP1B(h) --/ IGF1(h) (transrepression)
PTP1B(h) --/ IGF-1(h) (decrease of abundance)
PTP1B(h) --> STAT5(h){pY} (decrease of phosphorylation)
H2O2 --/ PTP1B(h) (inhibition)
superoxide --/ PTP1B(h) (inhibition)
PTPN1(h) --> PTP1B(h) (expression).
Crk-II(m.s.){pY221} --PTP1B(h)--> Crk-II(m.s.) + p (dephosphorylation)
Trpv6(r){pY} --PTP1B(h)--> Trpv6(r) + p (dephosphorylation)
Src(h){pY419}{pY530} --PTP1B(h)--> Src(h) + 2 p (dephosphorylation)
Src(h){pY530} --PTP1B(h)--> Src(h) + p (dephosphorylation)
InsR(h){pY} --PTP1B(h)--> InsR(h) + p (dephosphorylation)
IRS-1(h){pY} --PTP1B(h)--> IRS-1(h) + p (dephosphorylation)
Lck(m){pY} --PTP1B(h)--> Lck(m) + p (dephosphorylation)
LYZ(m.s.){pY} --PTP1B(h)--> p + LYZ(m.s.) (dephosphorylation)
Myosin-P-light chain(m.s.){pY} --PTP1B(h)--> p + Myosin-P-light chain(m.s.) (dephosphorylation)
Albumin(b){pY} --PTP1B(h)--> p + Albumin(b) (dephosphorylation)
MBP(m.s.){pY} --PTP1B(h)--> p + MBP(m.s.) (dephosphorylation)
PTPN1(h) --> PTP1B(h) (expression).
GHR(rb){pY} --PTP1B(h)--> GHR(rb) + p (dephosphorylation)
STAT5(h){pY} --PTP1B(h)--> STAT5(h) + p (dephosphorylation)
STAT3(h){pY} --PTP1B(h)--> STAT3(h) + p (dephosphorylation)

Human Primary Tumor Samples (U95)  | Top

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Human U133A/GNF1H Gene Atlas  | Top