lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5740
Symbol	PTGIS
Synonymous	CYP8\|CYP8A1\|PGIS\|PTGI
Full name	prostaglandin I2 (prostacyclin) synthase
Gene description	cytochrome P450, family 8, subfamily A, polypeptide 1\|prostacyclin synthase\|prostaglandin I2 synthase
Cytoband	20q13.13
Gene type	protein-coding
Synonymous	MIM:601699; HGNC:HGNC:9603; Ensembl:ENSG00000124212; HPRD:09046; Vega:OTTHUMG00000033077

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.879C>A; p.F293L; 20:49514372-49514372	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.781C>T; p.L261L; 20:49524132-49524132	skin	malignant_melanoma	Substitution - coding silent
c.781C>T; p.L261L; 20:49524132-49524132	skin	malignant_melanoma	Substitution - coding silent
c.175G>A; p.E59K; 20:49550089-49550089	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1432C>A; p.L478I; 20:49507991-49507991	pancreas	carcinoma	Substitution - Missense
c.927C>T; p.V309V; 20:49514324-49514324	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.252C>T; p.D84D; 20:49547966-49547966	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.975G>A; p.S325S; 20:49514276-49514276	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.256G>A; p.V86M; 20:49547962-49547962	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.128C>T; p.A43V; 20:49550136-49550136	skin	malignant_melanoma	Substitution - Missense
c.157T>C; p.F53L; 20:49550107-49550107	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.192C>A; p.I64I; 20:49550072-49550072	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.980C>T; p.T327M; 20:49514271-49514271	prostate	carcinoma	Substitution - Missense
c.905A>G; p.N302S; 20:49514346-49514346	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1058C>A; p.A353D; 20:49513228-49513228	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.103G>A; p.G35S; 20:49550161-49550161	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.192C>A; p.I64I; 20:49550072-49550072	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.828C>T; p.A276A; 20:49524085-49524085	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.960G>A; p.A320A; 20:49514291-49514291	pancreas	carcinoma	Substitution - coding silent
c.622C>T; p.R208C; 20:49539621-49539621	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.858G>A; p.G286G; 20:49514393-49514393	skin	malignant_melanoma	Substitution - coding silent
c.622C>T; p.R208C; 20:49539621-49539621	skin	malignant_melanoma	Substitution - Missense
c.622C>T; p.R208C; 20:49539621-49539621	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.622C>T; p.R208C; 20:49539621-49539621	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.746G>A; p.R249Q; 20:49524167-49524167	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.948C>T; p.I316I; 20:49514303-49514303	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.713G>A; p.W238*; 20:49524200-49524200	lung	carcinoid-endocrine_tumour; atypical	Substitution - Nonsense
c.272G>A; p.R91H; 20:49547946-49547946	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1133G>A; p.R378Q; 20:49513153-49513153	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.879C>G; p.F293L; 20:49514372-49514372	breast	carcinoma	Substitution - Missense
c.1012A>G; p.T338A; 20:49514239-49514239	pancreas	carcinoma	Substitution - Missense
c.1132C>T; p.R378*; 20:49513154-49513154	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.1228C>T; p.L410L; 20:49511158-49511158	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.88C>T; p.P30S; 20:49550176-49550176	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.88C>T; p.P30S; 20:49550176-49550176	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.337C>A; p.P113T; 20:49547881-49547881	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1331G>T; p.R444M; 20:49511055-49511055	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.864G>T; p.M288I; 20:49514387-49514387	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.793G>A; p.E265K; 20:49524120-49524120	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.793G>A; p.E265K; 20:49524120-49524120	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.909T>A; p.P303P; 20:49514342-49514342	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.623G>A; p.R208H; 20:49539620-49539620	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1120G>A; p.E374K; 20:49513166-49513166	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.723A>G; p.L241L; 20:49524190-49524190	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.723A>G; p.L241L; 20:49524190-49524190	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.107G>A; p.S36N; 20:49550157-49550157	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1304G>A; p.G435E; 20:49511082-49511082	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.931G>A; p.G311R; 20:49514320-49514320	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.254C>T; p.A85V; 20:49547964-49547964	oesophagus	carcinoma	Substitution - Missense
c.1401C>G; p.I467M; 20:49508022-49508022	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.647A>T; p.K216I; 20:49539596-49539596	skin	malignant_melanoma	Substitution - Missense
c.613C>T; p.H205Y; 20:49539630-49539630	oesophagus	carcinoma	Substitution - Missense
c.707G>A; p.R236H; 20:49524206-49524206	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.707G>A; p.R236H; 20:49524206-49524206	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.707G>A; p.R236H; 20:49524206-49524206	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.707G>A; p.R236H; 20:49524206-49524206	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.707G>A; p.R236H; 20:49524206-49524206	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.624C>T; p.R208R; 20:49539619-49539619	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.674G>T; p.G225V; 20:49524239-49524239	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.919G>T; p.A307S; 20:49514332-49514332	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.193T>G; p.F65V; 20:49550071-49550071	skin; mucosal	malignant_melanoma	Substitution - Missense
c.864G>A; p.M288I; 20:49514387-49514387	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1424A>C; p.E475A; 20:49507999-49507999	breast	carcinoma	Substitution - Missense
c.501C>T; p.F167F; 20:49544325-49544325	oesophagus	carcinoma	Substitution - coding silent
c.1186G>A; p.E396K; 20:49513100-49513100	skin	malignant_melanoma	Substitution - Missense
c.1414G>C; p.E472Q; 20:49508009-49508009	urinary_tract; bladder	carcinoma	Substitution - Missense
c.974C>T; p.S325L; 20:49514277-49514277	skin	malignant_melanoma	Substitution - Missense
c.522-1G>T; p.?; 20:49539722-49539722	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.555G>A; p.A185A; 20:49539688-49539688	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.217T>C; p.Y73H; 20:49548001-49548001	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.555G>A; p.A185A; 20:49539688-49539688	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.217T>C; p.Y73H; 20:49548001-49548001	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.894C>T; p.F298F; 20:49514357-49514357	skin; abdomen	malignant_melanoma	Substitution - coding silent
c.1030G>A; p.V344M; 20:49513256-49513256	liver	carcinoma	Substitution - Missense
c.1030G>A; p.V344M; 20:49513256-49513256	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1030G>A; p.V344M; 20:49513256-49513256	pancreas	carcinoma	Substitution - Missense
c.231C>T; p.L77L; 20:49547987-49547987	breast	carcinoma	Substitution - coding silent
c.1030G>A; p.V344M; 20:49513256-49513256	liver	carcinoma	Substitution - Missense
c.563G>A; p.R188H; 20:49539680-49539680	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1270G>T; p.G424W; 20:49511116-49511116	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1243T>C; p.S415P; 20:49511143-49511143	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.123_124insG; p.Y42fs*22; 20:49550140-49550141	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.891C>G; p.L297L; 20:49514360-49514360	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1464G>A; p.P488P; 20:49507959-49507959	stomach	adenocarcinoma	Substitution - coding silent
c.482_483insCA; p.E161fs*19; 20:49544343-49544344	breast	carcinoma	Insertion - Frameshift
c.1368C>T; p.F456F; 20:49508055-49508055	skin	malignant_melanoma	Substitution - coding silent
c.145G>T; p.D49Y; 20:49550119-49550119	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.723A>C; p.L241L; 20:49524190-49524190	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.356A>G; p.D119G; 20:49547862-49547862	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1331G>A; p.R444K; 20:49511055-49511055	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1499C>A; p.P500Q; 20:49507924-49507924	skin	malignant_melanoma	Substitution - Missense
c.1047C>T; p.L349L; 20:49513239-49513239	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.805T>C; p.S269P; 20:49524108-49524108	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.990C>T; p.L330L; 20:49514261-49514261	skin; trunk	malignant_melanoma; nodular	Substitution - coding silent
c.250G>A; p.D84N; 20:49547968-49547968	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1186G>T; p.E396*; 20:49513100-49513100	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.171G>T; p.M57I; 20:49550093-49550093	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.330G>A; p.V110V; 20:49547888-49547888	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1474G>A; p.V492M; 20:49507949-49507949	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.535A>T; p.T179S; 20:49539708-49539708	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1379T>C; p.V460A; 20:49508044-49508044	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.348C>A; p.S116R; 20:49547870-49547870	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.725C>T; p.S242F; 20:49524188-49524188	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.859A>G; p.N287D; 20:49514392-49514392	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.768G>A; p.L256L; 20:49524145-49524145	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.562C>A; p.R188S; 20:49539681-49539681	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.560C>G; p.P187R; 20:49539683-49539683	ovary	other; neoplasm	Substitution - Missense
c.1290C>A; p.Y430*; 20:49511096-49511096	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.560C>G; p.P187R; 20:49539683-49539683	ovary	other; neoplasm	Substitution - Missense
c.100C>A; p.L34M; 20:49550164-49550164	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.560C>G; p.P187R; 20:49539683-49539683	ovary	other; neoplasm	Substitution - Missense
c.560C>G; p.P187R; 20:49539683-49539683	ovary	other; neoplasm	Substitution - Missense
c.1164C>T; p.F388F; 20:49513122-49513122	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.674G>A; p.G225E; 20:49524239-49524239	skin	malignant_melanoma	Substitution - Missense
c.1093C>A; p.L365M; 20:49513193-49513193	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1306delG; p.A436fs*31; 20:49511080-49511080	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.544G>A; p.G182R; 20:49539699-49539699	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.737T>A; p.L246Q; 20:49524176-49524176	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1025-1G>A; p.?; 20:49513262-49513262	ovary	carcinoma; serous_carcinoma	Unknown
c.1488C>A; p.Y496*; 20:49507935-49507935	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.255G>A; p.A85A; 20:49547963-49547963	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.481G>A; p.E161K; 20:49544345-49544345	skin	malignant_melanoma	Substitution - Missense
c.1076G>A; p.R359H; 20:49513210-49513210	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.225C>T; p.T75T; 20:49547993-49547993	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1006G>A; p.D336N; 20:49514245-49514245	skin	malignant_melanoma	Substitution - Missense
c.1071C>T; p.I357I; 20:49513215-49513215	skin; arm	malignant_melanoma	Substitution - coding silent
c.932G>A; p.G311E; 20:49514319-49514319	skin	malignant_melanoma	Substitution - Missense
c.1118G>A; p.R373Q; 20:49513168-49513168	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1118G>A; p.R373Q; 20:49513168-49513168	skin	malignant_melanoma	Substitution - Missense
c.1118G>A; p.R373Q; 20:49513168-49513168	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1310G>A; p.G437E; 20:49511076-49511076	liver	carcinoma	Substitution - Missense
c.171G>A; p.M57I; 20:49550093-49550093	skin	malignant_melanoma	Substitution - Missense
c.1310G>A; p.G437E; 20:49511076-49511076	liver	carcinoma	Substitution - Missense
c.278G>T; p.R93M; 20:49547940-49547940	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1161C>T; p.P387P; 20:49513125-49513125	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.926T>A; p.V309D; 20:49514325-49514325	skin	malignant_melanoma	Substitution - Missense
c.1483C>T; p.R495C; 20:49507940-49507940	prostate	carcinoma	Substitution - Missense
c.725C>A; p.S242Y; 20:49524188-49524188	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.939C>T; p.L313L; 20:49514312-49514312	skin	malignant_melanoma	Substitution - coding silent
c.1113C>T; p.D371D; 20:49513173-49513173	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1113C>T; p.D371D; 20:49513173-49513173	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1004T>C; p.L335P; 20:49514247-49514247	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1467A>T; p.E489D; 20:49507956-49507956	breast	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation