lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5734
Symbol	PTGER4
Synonymous	EP4\|EP4R
Full name	prostaglandin E receptor 4 (subtype EP4)
Gene description	PGE receptor EP4 subtype\|PGE receptor, EP4 subtype\|PGE2 receptor EP4 subtype\|prostaglandin E2 receptor EP4 subtype\|prostanoid EP4 receptor
Cytoband	5p13.1
Gene type	protein-coding
Synonymous	MIM:601586; HGNC:HGNC:9596; Ensembl:ENSG00000171522; HPRD:03350; Vega:OTTHUMG00000094769

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.221C>T; p.P74L; 5:40681214-40681214	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1060T>G; p.S354A; 5:40691971-40691971	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1060T>G; p.S354A; 5:40691971-40691971	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1060T>G; p.S354A; 5:40691971-40691971	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1060T>G; p.S354A; 5:40691971-40691971	thyroid	other; neoplasm	Substitution - Missense
c.1060T>G; p.S354A; 5:40691971-40691971	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1060T>G; p.S354A; 5:40691971-40691971	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1060T>G; p.S354A; 5:40691971-40691971	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1060T>G; p.S354A; 5:40691971-40691971	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1060T>G; p.S354A; 5:40691971-40691971	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1060T>G; p.S354A; 5:40691971-40691971	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.232G>A; p.A78T; 5:40681225-40681225	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1060T>G; p.S354A; 5:40691971-40691971	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1401T>C; p.P467P; 5:40692312-40692312	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1060T>G; p.S354A; 5:40691971-40691971	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1060T>G; p.S354A; 5:40691971-40691971	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.482C>T; p.S161L; 5:40681475-40681475	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.447C>T; p.L149L; 5:40681440-40681440	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.447C>T; p.L149L; 5:40681440-40681440	skin	malignant_melanoma	Substitution - coding silent
c.297G>C; p.L99L; 5:40681290-40681290	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.539C>T; p.A180V; 5:40681532-40681532	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.731C>T; p.A244V; 5:40681724-40681724	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.345C>T; p.V115V; 5:40681338-40681338	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1179G>C; p.Q393H; 5:40692090-40692090	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1199C>T; p.S400L; 5:40692110-40692110	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1238A>C; p.N413T; 5:40692149-40692149	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1002G>C; p.K334N; 5:40691913-40691913	urinary_tract; bladder	carcinoma	Substitution - Missense
c.540G>A; p.A180A; 5:40681533-40681533	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1304G>A; p.R435Q; 5:40692215-40692215	skin	malignant_melanoma	Substitution - Missense
c.540G>A; p.A180A; 5:40681533-40681533	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.137G>A; p.R46H; 5:40681130-40681130	thyroid	carcinoma	Substitution - Missense
c.540G>A; p.A180A; 5:40681533-40681533	prostate	carcinoma	Substitution - coding silent
c.773G>A; p.R258Q; 5:40681766-40681766	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.930A>G; p.P310P; 5:40691841-40691841	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.389A>G; p.Y130C; 5:40681382-40681382	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.33C>A; p.S11S; 5:40681026-40681026	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.813C>T; p.V271V; 5:40681806-40681806	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.433G>A; p.A145T; 5:40681426-40681426	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.605G>A; p.C202Y; 5:40681598-40681598	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.407C>T; p.A136V; 5:40681400-40681400	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.605G>A; p.C202Y; 5:40681598-40681598	soft_tissue; striated_muscle	rhabdomyosarcoma; alveolar	Substitution - Missense
c.253T>G; p.W85G; 5:40681246-40681246	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1057G>A; p.G353R; 5:40691968-40691968	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.23C>T; p.S8L; 5:40681016-40681016	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.538G>A; p.A180T; 5:40681531-40681531	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.237G>A; p.T79T; 5:40681230-40681230	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.380A>G; p.Y127C; 5:40681373-40681373	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.60A>G; p.P20P; 5:40681053-40681053	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.60A>G; p.P20P; 5:40681053-40681053	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.299_301delTCT; p.F102delF; 5:40681292-40681294	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Deletion - In frame
c.370G>A; p.A124T; 5:40681363-40681363	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.472C>T; p.L158F; 5:40681465-40681465	pancreas	carcinoma	Substitution - Missense
c.1450T>G; p.S484A; 5:40692361-40692361	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1408A>G; p.S470G; 5:40692319-40692319	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.474C>T; p.L158L; 5:40681467-40681467	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1095C>T; p.D365D; 5:40692006-40692006	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1330C>G; p.Q444E; 5:40692241-40692241	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.43G>A; p.D15N; 5:40681036-40681036	bone; pelvis	chondrosarcoma	Substitution - Missense
c.1071G>T; p.E357D; 5:40691982-40691982	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1024G>A; p.E342K; 5:40691935-40691935	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.442G>A; p.V148M; 5:40681435-40681435	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.767G>A; p.R256H; 5:40681760-40681760	urinary_tract; bladder	carcinoma	Substitution - Missense
c.537G>A; p.T179T; 5:40681530-40681530	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1380C>A; p.S460R; 5:40692291-40692291	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.334G>T; p.A112S; 5:40681327-40681327	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1071G>A; p.E357E; 5:40691982-40691982	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.722A>C; p.H241P; 5:40681715-40681715	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1253T>C; p.V418A; 5:40692164-40692164	kidney	Wilms_tumour	Substitution - Missense
c.1298C>A; p.T433N; 5:40692209-40692209	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1278A>G; p.E426E; 5:40692189-40692189	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1063C>T; p.R355C; 5:40691974-40691974	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.117C>T; p.I39I; 5:40681110-40681110	skin	malignant_melanoma	Substitution - coding silent
c.346G>A; p.E116K; 5:40681339-40681339	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.334G>A; p.A112T; 5:40681327-40681327	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.159C>T; p.T53T; 5:40681152-40681152	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.630G>A; p.L210L; 5:40681623-40681623	breast	carcinoma	Substitution - coding silent
c.1380C>T; p.S460S; 5:40692291-40692291	breast	carcinoma	Substitution - coding silent
c.1015A>G; p.K339E; 5:40691926-40691926	prostate	carcinoma	Substitution - Missense
c.1094A>G; p.D365G; 5:40692005-40692005	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.609C>T; p.N203N; 5:40681602-40681602	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1295G>A; p.R432K; 5:40692206-40692206	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.937C>T; p.Q313*; 5:40691848-40691848	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.202G>T; p.G68C; 5:40681195-40681195	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1036T>C; p.C346R; 5:40691947-40691947	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.378C>T; p.F126F; 5:40681371-40681371	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1197C>G; p.L399L; 5:40692108-40692108	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.947G>A; p.R316Q; 5:40691858-40691858	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1417C>A; p.Q473K; 5:40692328-40692328	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.947G>A; p.R316Q; 5:40691858-40691858	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.437C>A; p.S146Y; 5:40681430-40681430	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.985T>C; p.Y329H; 5:40691896-40691896	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.401G>A; p.R134Q; 5:40681394-40681394	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.4T>C; p.S2P; 5:40680997-40680997	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1237A>C; p.N413H; 5:40692148-40692148	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.798C>G; p.A266A; 5:40681791-40681791	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1093G>T; p.D365Y; 5:40692004-40692004	breast	carcinoma	Substitution - Missense
c.1287C>A; p.T429T; 5:40692198-40692198	breast	carcinoma	Substitution - coding silent
c.964C>A; p.P322T; 5:40691875-40691875	skin	malignant_melanoma	Substitution - Missense
c.1289C>A; p.S430*; 5:40692200-40692200	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.111G>T; p.V37V; 5:40681104-40681104	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1185C>T; p.L395L; 5:40692096-40692096	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1431C>A; p.P477P; 5:40692342-40692342	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.259delG; p.G88fs*26; 5:40681252-40681252	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.140A>G; p.K47R; 5:40681133-40681133	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.916G>A; p.V306I; 5:40691827-40691827	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation