lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5617
Symbol	PRL
Synonymous	-
Full name	prolactin
Gene description	decidual prolactin
Cytoband	6p22.3
Gene type	protein-coding
Synonymous	MIM:176760; HGNC:HGNC:9445; Ensembl:ENSG00000172179; HPRD:07180; Vega:OTTHUMG00000016111

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.88C>G; p.P30A; 6:22294525-22294525	urinary_tract; bladder	carcinoma	Substitution - Missense
c.321C>G; p.D107E; 6:22290345-22290345	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.79G>A; p.A27T; 6:22294534-22294534	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.76G>A; p.V26M; 6:22294537-22294537	skin	malignant_melanoma	Substitution - Missense
c.420C>T; p.I140I; 6:22290246-22290246	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.113G>A; p.R38Q; 6:22294500-22294500	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.137T>A; p.L46Q; 6:22294476-22294476	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.291G>A; p.K97K; 6:22292559-22292559	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.676_678delAAC; p.N226delN; 6:22287408-22287410	large_intestine	carcinoma; adenocarcinoma	Deletion - In frame
c.676_678delAAC; p.N226delN; 6:22287408-22287410	large_intestine	carcinoma; adenocarcinoma	Deletion - In frame
c.410C>T; p.P137L; 6:22290256-22290256	pancreas	carcinoma	Substitution - Missense
c.337G>T; p.V113F; 6:22290329-22290329	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.575G>T; p.R192L; 6:22287511-22287511	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.539G>A; p.G180E; 6:22287547-22287547	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.489C>G; p.S163R; 6:22290177-22290177	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.527C>A; p.P176H; 6:22287559-22287559	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.396T>C; p.G132G; 6:22290270-22290270	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.163C>T; p.H55Y; 6:22294450-22294450	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3G>A; p.M1I; 6:22296980-22296980	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.496C>T; p.H166Y; 6:22287590-22287590	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.244G>T; p.A82S; 6:22292606-22292606	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.199G>A; p.E67K; 6:22294414-22294414	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.366T>C; p.P122P; 6:22290300-22290300	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.133G>T; p.D45Y; 6:22294480-22294480	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.154G>A; p.V52I; 6:22294459-22294459	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.18G>A; p.S6S; 6:22296965-22296965	prostate	carcinoma	Substitution - coding silent
c.13G>A; p.G5R; 6:22296970-22296970	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.31T>G; p.S11A; 6:22294582-22294582	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.31T>G; p.S11A; 6:22294582-22294582	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.31T>G; p.S11A; 6:22294582-22294582	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.31T>G; p.S11A; 6:22294582-22294582	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.31T>G; p.S11A; 6:22294582-22294582	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.31T>G; p.S11A; 6:22294582-22294582	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.31T>G; p.S11A; 6:22294582-22294582	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.313-5C>T; p.?; 6:22290358-22290358	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.377T>C; p.L126P; 6:22290289-22290289	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.464T>G; p.L155R; 6:22290202-22290202	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.130C>T; p.R44*; 6:22294483-22294483	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.130C>T; p.R44*; 6:22294483-22294483	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Nonsense
c.278C>T; p.T93I; 6:22292572-22292572	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.130C>T; p.R44*; 6:22294483-22294483	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.376C>T; p.L126L; 6:22290290-22290290	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.211C>T; p.R71W; 6:22292639-22292639	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.648C>T; p.L216L; 6:22287438-22287438	skin	malignant_melanoma	Substitution - coding silent
c.349C>T; p.R117*; 6:22290317-22290317	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.145C>T; p.R49C; 6:22294468-22294468	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.642C>T; p.L214L; 6:22287444-22287444	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.650T>G; p.L217R; 6:22287436-22287436	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.526C>G; p.P176A; 6:22287560-22287560	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.383C>T; p.T128M; 6:22290283-22290283	pancreas	carcinoma	Substitution - Missense
c.614G>T; p.R205M; 6:22287472-22287472	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.381C>T; p.V127V; 6:22290285-22290285	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.381C>T; p.V127V; 6:22290285-22290285	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.661A>C; p.I221L; 6:22287425-22287425	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.575G>A; p.R192H; 6:22287511-22287511	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.9C>T; p.I3I; 6:22296974-22296974	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.135C>T; p.D45D; 6:22294478-22294478	skin	malignant_melanoma	Substitution - coding silent
c.442G>A; p.E148K; 6:22290224-22290224	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.319G>A; p.D107N; 6:22290347-22290347	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.147C>T; p.R49R; 6:22294466-22294466	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.533G>A; p.W178*; 6:22287553-22287553	skin	malignant_melanoma	Substitution - Nonsense
c.279C>T; p.T93T; 6:22292571-22292571	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.314A>C; p.Q105P; 6:22290352-22290352	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.75C>T; p.S25S; 6:22294538-22294538	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.75C>T; p.S25S; 6:22294538-22294538	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.29-4G>T; p.?; 6:22294588-22294588	ovary	other; neoplasm	Unknown
c.29-4G>T; p.?; 6:22294588-22294588	ovary	other; neoplasm	Unknown
c.628A>G; p.I210V; 6:22287458-22287458	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.570G>A; p.E190E; 6:22287516-22287516	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.205G>A; p.D69N; 6:22292645-22292645	NS	malignant_melanoma	Substitution - Missense
c.148G>T; p.A50S; 6:22294465-22294465	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.149C>T; p.A50V; 6:22294464-22294464	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.204C>T; p.F68F; 6:22294409-22294409	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.204C>T; p.F68F; 6:22294409-22294409	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.204C>T; p.F68F; 6:22294409-22294409	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.383C>G; p.T128R; 6:22290283-22290283	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.204C>T; p.F68F; 6:22294409-22294409	skin	malignant_melanoma	Substitution - coding silent
c.204C>T; p.F68F; 6:22294409-22294409	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.204C>T; p.F68F; 6:22294409-22294409	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.204C>T; p.F68F; 6:22294409-22294409	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.452C>T; p.T151I; 6:22290214-22290214	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.66G>A; p.L22L; 6:22294547-22294547	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.357G>C; p.W119C; 6:22290309-22290309	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.559G>A; p.A187T; 6:22287527-22287527	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.333G>C; p.L111L; 6:22290333-22290333	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.576C>T; p.R192R; 6:22287510-22287510	liver	carcinoma	Substitution - coding silent
c.659G>A; p.R220Q; 6:22287427-22287427	pancreas	carcinoma	Substitution - Missense
c.576C>T; p.R192R; 6:22287510-22287510	liver	carcinoma	Substitution - coding silent
c.659G>A; p.R220Q; 6:22287427-22287427	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.384G>A; p.T128T; 6:22290282-22290282	liver	carcinoma	Substitution - coding silent
c.131G>A; p.R44Q; 6:22294482-22294482	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.642C>G; p.L214L; 6:22287444-22287444	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation