Cancer metastasis database

Annotation category 5

Gene information

Gene ID 5515
Symbol

PPP2CA

Synonymous

PP2Ac|PP2CA|PP2Calpha|RP-C

Full name

protein phosphatase 2, catalytic subunit, alpha isozyme

Gene description

PP2A-alpha|protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform|protein phosphatase 2A catalytic subunit, alpha isoform|replication protein C|serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform|serine/threonine-prote

Cytoband

5q31.1

Gene type

protein-coding

Synonymous

MIM:176915; HGNC:HGNC:9299; HPRD:08912

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.393T>C; p.D131D; 5:134201941-134201941

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.513G>A; p.S171S; 5:134201048-134201048

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.513G>A; p.S171S; 5:134201048-134201048

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.19A>G; p.T7A; 5:134225843-134225843

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.523G>C; p.D175H; 5:134201038-134201038

 livercarcinomaSubstitution - Missense

c.759C>T; p.D253D; 5:134199184-134199184

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.146G>A; p.R49Q; 5:134206088-134206088

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.664C>G; p.Q222E; 5:134200409-134200409

 livercarcinomaSubstitution - Missense

c.664C>G; p.Q222E; 5:134200409-134200409

 livercarcinomaSubstitution - Missense

c.862C>T; p.Q288*; 5:134197840-134197840

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

c.793T>A; p.Y265N; 5:134199150-134199150

 central_nervous_system; braingliomaSubstitution - Missense

c.676G>C; p.E226Q; 5:134200397-134200397

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.334A>G; p.T112A; 5:134202000-134202000

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.837C>T; p.D279D; 5:134199106-134199106

 bone; pelvisEwings_sarcoma-peripheral_primitive_neuroectodermal_tumourSubstitution - coding silent

c.508C>A; p.L170I; 5:134201053-134201053

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.460C>T; p.P154S; 5:134201874-134201874

 breastcarcinomaSubstitution - Missense

c.377T>C; p.V126A; 5:134201957-134201957

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.331A>T; p.I111F; 5:134202003-134202003

 livercarcinomaSubstitution - Missense

c.673T>C; p.S225P; 5:134200400-134200400

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.28C>T; p.L10L; 5:134225834-134225834

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - coding silent

c.194T>C; p.L65P; 5:134206040-134206040

 central_nervous_system; brainglioma; oligoastrocytomaSubstitution - Missense

c.492C>A; p.F164L; 5:134201069-134201069

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.752G>T; p.C251F; 5:134199191-134199191

 adrenal_gland; adrenal_glandadrenal_cortical_carcinoma; functioningSubstitution - Missense

c.200_218del19; p.E67fs*29; 5:134206016-134206034

 breastcarcinomaDeletion - Frameshift

c.617G>A; p.R206H; 5:134200456-134200456

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.617G>A; p.R206H; 5:134200456-134200456

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.640C>T; p.R214*; 5:134200433-134200433

 skin; abdomenmalignant_melanomaSubstitution - Nonsense

c.159T>C; p.T53T; 5:134206075-134206075

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.889G>A; p.E297K; 5:134197813-134197813

 breastcarcinomaSubstitution - Missense

c.924C>A; p.F308L; 5:134197778-134197778

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.803G>A; p.R268H; 5:134199140-134199140

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.589G>T; p.D197Y; 5:134200484-134200484

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.363A>G; p.R121R; 5:134201971-134201971

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.363A>G; p.R121R; 5:134201971-134201971

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.343C>T; p.R115*; 5:134201991-134201991

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.145C>T; p.R49*; 5:134206089-134206089

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.145C>T; p.R49*; 5:134206089-134206089

 ovarycarcinoma; serous_carcinomaSubstitution - Nonsense

c.283G>A; p.E95K; 5:134205951-134205951

 biliary_tract; gallbladdercarcinoma; adenocarcinomaSubstitution - Missense

c.659T>C; p.F220S; 5:134200414-134200414

 skinmalignant_melanomaSubstitution - Missense

c.329G>A; p.R110H; 5:134202005-134202005

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.329G>A; p.R110H; 5:134202005-134202005

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.219C>T; p.G73G; 5:134206015-134206015

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.526A>G; p.T176A; 5:134201035-134201035

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.408A>G; p.K136K; 5:134201926-134201926

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.840T>C; p.D280D; 5:134199103-134199103

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.115C>T; p.L39L; 5:134206119-134206119

 skinmalignant_melanomaSubstitution - coding silent

c.914delC; p.P305fs*>5; 5:134197788-134197788

 pancreascarcinoma; acinar_carcinomaDeletion - Frameshift

c.389A>G; p.Y130C; 5:134201945-134201945

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.733A>T; p.M245L; 5:134200340-134200340

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.362G>C; p.R121T; 5:134201972-134201972

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.489C>A; p.I163I; 5:134201072-134201072

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent