lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	54345
Symbol	SOX18
Synonymous	HLTS
Full name	SRY (sex determining region Y)-box 18
Gene description	SRY-box 18\|transcription factor SOX-18
Cytoband	20q13.33
Gene type	protein-coding
Synonymous	MIM:601618; HGNC:HGNC:11194; Ensembl:ENSG00000203883; HPRD:07208; Vega:OTTHUMG00000033017

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.395G>A; p.R132Q; 20:64048926-64048926	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.326A>G; p.D109G; 20:64049191-64049191	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1098C>T; p.I366I; 20:64048223-64048223	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.338C>A; p.A113E; 20:64049179-64049179	large_intestine	adenoma	Substitution - Missense
c.336C>T; p.N112N; 20:64049181-64049181	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.420G>A; p.R140R; 20:64048901-64048901	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.313C>G; p.Q105E; 20:64049204-64049204	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1009C>T; p.R337W; 20:64048312-64048312	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.231C>T; p.R77R; 20:64049286-64049286	skin	malignant_melanoma	Substitution - coding silent
c.434A>G; p.H145R; 20:64048887-64048887	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.434A>G; p.H145R; 20:64048887-64048887	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.318G>T; p.Q106H; 20:64049199-64049199	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.205C>T; p.L69F; 20:64049312-64049312	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.212C>G; p.P71R; 20:64049305-64049305	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.212C>G; p.P71R; 20:64049305-64049305	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1023delC; p.L343fs*23; 20:64048298-64048298	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.975C>T; p.T325T; 20:64048346-64048346	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1039G>A; p.V347M; 20:64048282-64048282	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense