lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	5328
Symbol	PLAU
Synonymous	ATF\|BDPLT5\|QPD\|UPA\|URK\|u-PA
Full name	plasminogen activator, urokinase
Gene description	U-plasminogen activator\|plasminogen activator, urinary\|urokinase-type plasminogen activator
Cytoband	10q22.2
Gene type	protein-coding
Synonymous	MIM:191840; HGNC:HGNC:9052; Ensembl:ENSG00000122861; HPRD:01883; Vega:OTTHUMG00000018494

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.422T>C; p.L141P; 10:73913343-73913343	thyroid	other; neoplasm	Substitution - Missense
c.822C>T; p.N274N; 10:73914121-73914121	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.351G>A; p.G117G; 10:73913081-73913081	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1187G>T; p.W396L; 10:73916456-73916456	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.272G>T; p.C91F; 10:73913002-73913002	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1222G>A; p.V408I; 10:73916491-73916491	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1222G>A; p.V408I; 10:73916491-73916491	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1091A>G; p.D364G; 10:73915371-73915371	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.622G>A; p.V208M; 10:73913700-73913700	liver	carcinoma	Substitution - Missense
c.388C>T; p.R130*; 10:73913309-73913309	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.388C>T; p.R130*; 10:73913309-73913309	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1226A>T; p.Y409F; 10:73916495-73916495	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.678C>T; p.F226F; 10:73913756-73913756	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.744G>T; p.T248T; 10:73914043-73914043	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.398G>T; p.C133F; 10:73913319-73913319	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.265C>T; p.R89W; 10:73912995-73912995	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1264C>A; p.H422N; 10:73916533-73916533	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1042C>T; p.P348S; 10:73915322-73915322	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.105T>C; p.N35N; 10:73912234-73912234	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.224G>A; p.G75D; 10:73912954-73912954	breast	carcinoma	Substitution - Missense
c.681-7C>T; p.?; 10:73913973-73913973	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1141G>A; p.V381I; 10:73916410-73916410	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.824A>G; p.D275G; 10:73914123-73914123	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.517C>G; p.L173V; 10:73913595-73913595	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.866C>T; p.A289V; 10:73914812-73914812	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.866C>T; p.A289V; 10:73914812-73914812	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.601_602insG; p.S204fs*25; 10:73913679-73913680	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.601_602insG; p.S204fs*25; 10:73913679-73913680	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.875C>T; p.S292F; 10:73914821-73914821	skin	malignant_melanoma	Substitution - Missense
c.287C>T; p.S96F; 10:73913017-73913017	urinary_tract; bladder	carcinoma	Substitution - Missense
c.287C>T; p.S96F; 10:73913017-73913017	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.527G>A; p.R176H; 10:73913605-73913605	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.840G>T; p.K280N; 10:73914786-73914786	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1069A>G; p.T357A; 10:73915349-73915349	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.740A>G; p.N247S; 10:73914039-73914039	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.476C>T; p.S159F; 10:73913554-73913554	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.199T>A; p.S67T; 10:73912929-73912929	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.171C>T; p.F57F; 10:73912300-73912300	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.171C>T; p.F57F; 10:73912300-73912300	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.171C>T; p.F57F; 10:73912300-73912300	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.131A>G; p.Y44C; 10:73912260-73912260	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.131A>G; p.Y44C; 10:73912260-73912260	liver	carcinoma	Substitution - Missense
c.1011G>A; p.V337V; 10:73915291-73915291	breast	carcinoma	Substitution - coding silent
c.708C>T; p.I236I; 10:73914007-73914007	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.76C>G; p.Q26E; 10:73912059-73912059	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1053C>T; p.Y351Y; 10:73915333-73915333	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.212A>T; p.Y71F; 10:73912942-73912942	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1273G>A; p.E425K; 10:73916542-73916542	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.806C>T; p.T269M; 10:73914105-73914105	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.602delG; p.G203fs*17; 10:73913680-73913680	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.602delG; p.G203fs*17; 10:73913680-73913680	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.602delG; p.G203fs*17; 10:73913680-73913680	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.602delG; p.G203fs*17; 10:73913680-73913680	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.200C>G; p.S67*; 10:73912930-73912930	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1121G>A; p.G374E; 10:73916390-73916390	skin	malignant_melanoma	Substitution - Missense
c.86-8C>G; p.?; 10:73912207-73912207	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.642C>T; p.I214I; 10:73913720-73913720	skin	malignant_melanoma	Substitution - coding silent
c.1250C>T; p.P417L; 10:73916519-73916519	skin	malignant_melanoma	Substitution - Missense
c.462delA; p.K156fs*9; 10:73913540-73913540	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.462delA; p.K156fs*9; 10:73913540-73913540	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.647C>G; p.P216R; 10:73913725-73913725	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1232G>C; p.R411T; 10:73916501-73916501	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1020T>G; p.I340M; 10:73915300-73915300	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1048T>C; p.Y350H; 10:73915328-73915328	breast	carcinoma	Substitution - Missense
c.1276G>C; p.E426Q; 10:73916545-73916545	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1002G>C; p.M334I; 10:73915282-73915282	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.547G>T; p.E183*; 10:73913625-73913625	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.547G>T; p.E183*; 10:73913625-73913625	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.547G>T; p.E183*; 10:73913625-73913625	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.906G>A; p.S302S; 10:73914852-73914852	skin	malignant_melanoma	Substitution - coding silent
c.744G>A; p.T248T; 10:73914043-73914043	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1025A>C; p.H342P; 10:73915305-73915305	breast	carcinoma	Substitution - Missense
c.43G>T; p.V15L; 10:73911598-73911598	thyroid	other; neoplasm	Substitution - Missense
c.429C>T; p.V143V; 10:73913350-73913350	skin	malignant_melanoma	Substitution - coding silent
c.446A>G; p.H149R; 10:73913367-73913367	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1093C>A; p.P365T; 10:73915373-73915373	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.474C>T; p.S158S; 10:73913552-73913552	skin	malignant_melanoma	Substitution - coding silent
c.696G>A; p.K232K; 10:73913995-73913995	skin	malignant_melanoma	Substitution - coding silent
c.1085C>T; p.A362V; 10:73915365-73915365	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.999A>T; p.K333N; 10:73915279-73915279	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.522G>A; p.R174R; 10:73913600-73913600	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.987G>A; p.P329P; 10:73915267-73915267	central_nervous_system; brain	glioma	Substitution - coding silent
c.165G>A; p.K55K; 10:73912294-73912294	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.606G>T; p.G202G; 10:73913684-73913684	liver	carcinoma	Substitution - coding silent
c.940G>A; p.E314K; 10:73914886-73914886	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.487G>T; p.E163*; 10:73913565-73913565	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.617C>T; p.T206I; 10:73913695-73913695	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation