lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	468
Symbol	ATF4
Synonymous	CREB-2\|CREB2\|TAXREB67\|TXREB
Full name	activating transcription factor 4
Gene description	DNA-binding protein TAXREB67\|cAMP response element-binding protein 2\|cAMP-dependent transcription factor ATF-4\|cAMP-responsive element-binding protein 2\|cyclic AMP-dependent transcription factor ATF-4\|cyclic AMP-responsive element-binding protein 2\|tax-re
Cytoband	22q13.1
Gene type	protein-coding
Synonymous	MIM:604064; HGNC:HGNC:786; Ensembl:ENSG00000128272; HPRD:06817; Vega:OTTHUMG00000151099

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.441T>C; p.S147S; 22:39521987-39521987	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.781_782insA; p.Y261fs*1; 22:39522327-39522328	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Insertion - Frameshift
c.674C>T; p.P225L; 22:39522220-39522220	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.40G>T; p.G14W; 22:39521485-39521485	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.912G>T; p.E304D; 22:39522458-39522458	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.641C>T; p.P214L; 22:39522187-39522187	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.644C>T; p.S215L; 22:39522190-39522190	skin	malignant_melanoma	Substitution - Missense
c.614C>T; p.P205L; 22:39522160-39522160	urinary_tract; bladder	carcinoma	Substitution - Missense
c.614C>T; p.P205L; 22:39522160-39522160	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.386A>G; p.E129G; 22:39521932-39521932	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.65A>C; p.Q22P; 22:39521510-39521510	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.65A>C; p.Q22P; 22:39521510-39521510	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.423T>G; p.I141M; 22:39521969-39521969	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.93A>G; p.L31L; 22:39521538-39521538	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.386A>C; p.E129A; 22:39521932-39521932	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.773C>T; p.P258L; 22:39522319-39522319	skin	malignant_melanoma	Substitution - Missense
c.528_531delTTCC; p.S177fs*3; 22:39522074-39522077	breast	carcinoma	Deletion - Frameshift
c.467C>T; p.P156L; 22:39522013-39522013	skin	malignant_melanoma	Substitution - Missense
c.302G>A; p.G101D; 22:39521848-39521848	skin; trunk	malignant_melanoma	Substitution - Missense
c.617A>G; p.Q206R; 22:39522163-39522163	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.531C>G; p.S177S; 22:39522077-39522077	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.693T>A; p.S231S; 22:39522239-39522239	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.466C>T; p.P156S; 22:39522012-39522012	skin	malignant_melanoma	Substitution - Missense
c.125A>G; p.K42R; 22:39521570-39521570	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.31G>C; p.V11L; 22:39521476-39521476	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.779C>T; p.P260L; 22:39522325-39522325	skin	malignant_melanoma	Substitution - Missense
c.286T>C; p.L96L; 22:39521832-39521832	breast	carcinoma	Substitution - coding silent
c.454G>C; p.D152H; 22:39522000-39522000	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.226+1G>A; p.?; 22:39521672-39521672	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Unknown
c.168G>A; p.A56A; 22:39521613-39521613	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.680C>T; p.S227F; 22:39522226-39522226	skin	malignant_melanoma	Substitution - Missense
c.150C>T; p.S50S; 22:39521595-39521595	skin	malignant_melanoma	Substitution - coding silent
c.262A>G; p.K88E; 22:39521808-39521808	pancreas	carcinoma	Substitution - Missense
c.697C>G; p.Q233E; 22:39522243-39522243	breast	carcinoma	Substitution - Missense
c.211T>G; p.S71A; 22:39521656-39521656	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.381C>G; p.V127V; 22:39521927-39521927	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1002G>A; p.L334L; 22:39522548-39522548	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.308A>G; p.D103G; 22:39521854-39521854	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.60C>G; p.F20L; 22:39521505-39521505	breast	carcinoma	Substitution - Missense
c.508C>A; p.L170M; 22:39522054-39522054	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.731G>T; p.R244M; 22:39522277-39522277	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.367delT; p.F123fs*4; 22:39521913-39521913	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.174C>T; p.S58S; 22:39521619-39521619	pancreas	carcinoma	Substitution - coding silent
c.631G>T; p.E211*; 22:39522177-39522177	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.557T>G; p.V186G; 22:39522103-39522103	thyroid	other; neoplasm	Substitution - Missense
c.429T>A; p.H143Q; 22:39521975-39521975	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.513C>A; p.S171S; 22:39522059-39522059	skin	malignant_melanoma	Substitution - coding silent
c.305T>C; p.I102T; 22:39521851-39521851	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.847delA; p.M285fs*36; 22:39522393-39522393	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.847delA; p.M285fs*36; 22:39522393-39522393	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.56C>T; p.P19L; 22:39521501-39521501	skin	malignant_melanoma	Substitution - Missense
c.400delC; p.Q136fs*3; 22:39521946-39521946	skin	malignant_melanoma	Deletion - Frameshift
c.400delC; p.Q136fs*3; 22:39521946-39521946	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.400delC; p.Q136fs*3; 22:39521946-39521946	pancreas	carcinoma; ductal_carcinoma	Deletion - Frameshift
c.1A>G; p.M1V; 22:39521446-39521446	liver	carcinoma	Substitution - Missense
c.83A>T; p.E28V; 22:39521528-39521528	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.83A>T; p.E28V; 22:39521528-39521528	liver	carcinoma	Substitution - Missense
c.413T>G; p.V138G; 22:39521959-39521959	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.780T>G; p.P260P; 22:39522326-39522326	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.53C>T; p.S18F; 22:39521498-39521498	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation