Cancer metastasis database

Annotation category 5

Gene information

Gene ID 4521
Symbol

NUDT1

Synonymous

MTH1

Full name

nudix (nucleoside diphosphate linked moiety X)-type motif 1

Gene description

2-hydroxy-dATP diphosphatase|7,8-dihydro-8-oxoguanine triphosphatase|8-oxo-7,8-dihydrodeoxyguanosine triphosphatase|8-oxo-7,8-dihydroguanosine triphosphatase|8-oxo-dGTPase|mutT human homolog 1|nucleoside diphosphate-linked moiety X motif 1|nucleoside diph

Cytoband

7p22

Gene type

protein-coding

Synonymous

MIM:600312; HGNC:HGNC:8048; Ensembl:ENSG00000106268; HPRD:02634; Vega:OTTHUMG00000023072

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.157G>A; p.G53S; 7:2244662-2244662

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.495_496insC; p.D166fs*>15; 7:2250956-2250957

 skinmalignant_melanomaInsertion - Frameshift

c.495_496insC; p.D166fs*>15; 7:2250956-2250957

 skinmalignant_melanomaInsertion - Frameshift

c.129G>C; p.L43L; 7:2244634-2244634

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.473G>C; p.G158A; 7:2250934-2250934

 livercarcinomaSubstitution - Missense

c.473G>C; p.G158A; 7:2250934-2250934

 livercarcinomaSubstitution - Missense

c.100C>A; p.L34M; 7:2244605-2244605

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.100C>A; p.L34M; 7:2244605-2244605

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.112C>T; p.P38S; 7:2244617-2244617

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.112C>T; p.P38S; 7:2244617-2244617

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.402C>G; p.I134M; 7:2250863-2250863

 kidneyother; neoplasmSubstitution - Missense

c.205G>A; p.E69K; 7:2244710-2244710

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.196G>A; p.E66K; 7:2244701-2244701

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.129G>A; p.L43L; 7:2244634-2244634

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.271G>A; p.G91S; 7:2249906-2249906

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.320A>G; p.H107R; 7:2249955-2249955

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.255C>T; p.D85D; 7:2249890-2249890

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.417G>A; p.M139I; 7:2250878-2250878

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.417G>A; p.M139I; 7:2250878-2250878

 livercarcinomaSubstitution - Missense

c.373C>T; p.R125C; 7:2250834-2250834

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.496G>A; p.D166N; 7:2250957-2250957

 thyroidcarcinoma; medullary_carcinomaSubstitution - Missense

c.534G>A; p.T178T; 7:2250995-2250995

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.326T>C; p.F109S; 7:2249961-2249961

 skinmalignant_melanomaSubstitution - Missense

c.75C>T; p.G25G; 7:2244580-2244580

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.76G>A; p.A26T; 7:2244581-2244581

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.459G>T; p.K153N; 7:2250920-2250920

 livercarcinomaSubstitution - Missense

c.291C>T; p.F97F; 7:2249926-2249926

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.297C>T; p.G99G; 7:2249932-2249932

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.291C>T; p.F97F; 7:2249926-2249926

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.472G>A; p.G158R; 7:2250933-2250933

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.426C>T; p.D142D; 7:2250887-2250887

 thyroidother; neoplasmSubstitution - coding silent

c.471C>T; p.H157H; 7:2250932-2250932

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.533C>T; p.T178M; 7:2250994-2250994

 breastcarcinomaSubstitution - Missense

c.533C>T; p.T178M; 7:2250994-2250994

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.430A>G; p.S144G; 7:2250891-2250891

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.157G>T; p.G53C; 7:2244662-2244662

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.367G>A; p.E123K; 7:2250002-2250002

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.378A>G; p.P126P; 7:2250839-2250839

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.74G>C; p.G25A; 7:2244579-2244579

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.150C>T; p.F50F; 7:2244655-2244655

 breastcarcinomaSubstitution - coding silent

c.142C>T; p.R48*; 7:2244647-2244647

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense