lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4103
Symbol	MAGEA4
Synonymous	CT1.4\|MAGE-41\|MAGE-X2\|MAGE4\|MAGE4A\|MAGE4B
Full name	melanoma antigen family A4
Gene description	MAGE-4 antigen\|MAGE-41 antigen\|MAGE-X2 antigen\|cancer/testis antigen 1.4\|cancer/testis antigen family 1, member 4\|melanoma antigen family A, 4\|melanoma-associated antigen 4
Cytoband	Xq28
Gene type	protein-coding
Synonymous	MIM:300175; HGNC:HGNC:6802; Ensembl:ENSG00000147381; HPRD:02167; Vega:OTTHUMG00000024174

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.63G>C; p.E21D; 23:151923727-151923727	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.704G>A; p.R235K; 23:151924368-151924368	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.803C>A; p.A268E; 23:151924467-151924467	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.731G>T; p.R244M; 23:151924395-151924395	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.284G>A; p.G95E; 23:151923948-151923948	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.657G>A; p.E219E; 23:151924321-151924321	skin	malignant_melanoma	Substitution - coding silent
c.115G>T; p.A39S; 23:151923779-151923779	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.115G>T; p.A39S; 23:151923779-151923779	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.642C>T; p.G214G; 23:151924306-151924306	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.642C>T; p.G214G; 23:151924306-151924306	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.446C>T; p.P149L; 23:151924110-151924110	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.457G>T; p.G153C; 23:151924121-151924121	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.457G>T; p.G153C; 23:151924121-151924121	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.287C>A; p.P96Q; 23:151923951-151923951	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.287C>A; p.P96Q; 23:151923951-151923951	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.732G>A; p.R244R; 23:151924396-151924396	skin	malignant_melanoma	Substitution - coding silent
c.732G>A; p.R244R; 23:151924396-151924396	skin	malignant_melanoma	Substitution - coding silent
c.163C>T; p.P55S; 23:151923827-151923827	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.839C>T; p.A280V; 23:151924503-151924503	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.140T>C; p.V47A; 23:151923804-151923804	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.794G>C; p.S265T; 23:151924458-151924458	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.303C>T; p.D101D; 23:151923967-151923967	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.296C>T; p.S99L; 23:151923960-151923960	skin; scalp	malignant_melanoma	Substitution - Missense
c.583C>T; p.Q195*; 23:151924247-151924247	skin	malignant_melanoma	Substitution - Nonsense
c.91C>G; p.P31A; 23:151923755-151923755	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.384G>A; p.K128K; 23:151924048-151924048	breast	carcinoma	Substitution - coding silent
c.742A>G; p.T248A; 23:151924406-151924406	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.159A>G; p.E53E; 23:151923823-151923823	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.592C>T; p.P198S; 23:151924256-151924256	skin	malignant_melanoma	Substitution - Missense
c.645C>A; p.D215E; 23:151924309-151924309	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.280G>A; p.E94K; 23:151923944-151923944	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.280G>A; p.E94K; 23:151923944-151923944	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.469G>A; p.E157K; 23:151924133-151924133	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.799C>T; p.P267S; 23:151924463-151924463	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.483G>A; p.M161I; 23:151924147-151924147	skin	malignant_melanoma	Substitution - Missense
c.39G>A; p.E13E; 23:151923703-151923703	skin	malignant_melanoma	Substitution - coding silent
c.458G>A; p.G153D; 23:151924122-151924122	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.939G>A; p.E313E; 23:151924603-151924603	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.474C>T; p.S158S; 23:151924138-151924138	skin	malignant_melanoma	Substitution - coding silent
c.458G>A; p.G153D; 23:151924122-151924122	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.83C>T; p.A28V; 23:151923747-151923747	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.468C>T; p.S156S; 23:151924132-151924132	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.457delG; p.G153fs*7; 23:151924121-151924121	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.546C>A; p.C182*; 23:151924210-151924210	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.174_187del14; p.E58fs*24; 23:151923838-151923851	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.830G>A; p.R277K; 23:151924494-151924494	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.156G>T; p.E52D; 23:151923820-151923820	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.406delA; p.M136fs*15; 23:151924070-151924070	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Deletion - Frameshift
c.557C>T; p.S186F; 23:151924221-151924221	skin	malignant_melanoma	Substitution - Missense
c.157G>A; p.E53K; 23:151923821-151923821	skin	malignant_melanoma	Substitution - Missense
c.643G>A; p.D215N; 23:151924307-151924307	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.615C>T; p.I205I; 23:151924279-151924279	breast	carcinoma	Substitution - coding silent
c.467C>T; p.S156F; 23:151924131-151924131	skin	malignant_melanoma	Substitution - Missense
c.467C>T; p.S156F; 23:151924131-151924131	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.922G>A; p.A308T; 23:151924586-151924586	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.517G>A; p.A173T; 23:151924181-151924181	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.309G>A; p.E103E; 23:151923973-151923973	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.663A>C; p.E221D; 23:151924327-151924327	liver	carcinoma	Substitution - Missense
c.663A>C; p.E221D; 23:151924327-151924327	liver	carcinoma	Substitution - Missense
c.640G>C; p.G214R; 23:151924304-151924304	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.943G>T; p.E315*; 23:151924607-151924607	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.376C>T; p.R126*; 23:151924040-151924040	skin	malignant_melanoma	Substitution - Nonsense
c.673G>A; p.E225K; 23:151924337-151924337	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.895C>T; p.R299C; 23:151924559-151924559	skin	malignant_melanoma	Substitution - Missense
c.895C>T; p.R299C; 23:151924559-151924559	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.118_119insC; p.V40fs*19; 23:151923782-151923783	lung	carcinoma; adenocarcinoma	Insertion - Frameshift
c.397A>C; p.K133Q; 23:151924061-151924061	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.227T>A; p.I76N; 23:151923891-151923891	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.743C>T; p.T248I; 23:151924407-151924407	skin	malignant_melanoma	Substitution - Missense
c.616G>A; p.V206I; 23:151924280-151924280	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.76G>T; p.V26L; 23:151923740-151923740	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.355C>T; p.H119Y; 23:151924019-151924019	skin	malignant_melanoma	Substitution - Missense
c.661G>A; p.E221K; 23:151924325-151924325	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.45C>T; p.G15G; 23:151923709-151923709	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.45C>T; p.G15G; 23:151923709-151923709	liver	carcinoma	Substitution - coding silent
c.661G>A; p.E221K; 23:151924325-151924325	skin	malignant_melanoma	Substitution - Missense
c.299C>T; p.P100L; 23:151923963-151923963	skin	malignant_melanoma	Substitution - Missense
c.752G>T; p.W251L; 23:151924416-151924416	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.218C>T; p.P73L; 23:151923882-151923882	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.663A>G; p.E221E; 23:151924327-151924327	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.552C>A; p.G184G; 23:151924216-151924216	skin	malignant_melanoma	Substitution - coding silent
c.803C>T; p.A268V; 23:151924467-151924467	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.10G>A; p.E4K; 23:151923674-151923674	breast	carcinoma	Substitution - Missense
c.750T>A; p.D250E; 23:151924414-151924414	kidney	other; neoplasm	Substitution - Missense
c.805C>T; p.R269C; 23:151924469-151924469	breast	carcinoma	Substitution - Missense
c.77T>G; p.V26G; 23:151923741-151923741	breast	carcinoma	Substitution - Missense
c.85C>A; p.Q29K; 23:151923749-151923749	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.248A>G; p.Q83R; 23:151923912-151923912	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.480G>T; p.K160N; 23:151924144-151924144	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.17A>G; p.K6R; 23:151923681-151923681	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.17A>G; p.K6R; 23:151923681-151923681	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.498C>T; p.D166D; 23:151924162-151924162	prostate	carcinoma	Substitution - coding silent
c.721G>T; p.G241W; 23:151924385-151924385	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.275A>T; p.E92V; 23:151923939-151923939	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.368G>A; p.R123H; 23:151924032-151924032	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.602G>T; p.G201V; 23:151924266-151924266	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.365T>C; p.L122P; 23:151924029-151924029	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.18G>A; p.K6K; 23:151923682-151923682	skin	malignant_melanoma	Substitution - coding silent
c.691G>C; p.V231L; 23:151924355-151924355	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.120_122delCTC; p.S44delS; 23:151923784-151923786	ovary	carcinoma; serous_carcinoma	Deletion - In frame
c.256G>A; p.E86K; 23:151923920-151923920	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.560A>G; p.Y187C; 23:151924224-151924224	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.256G>A; p.E86K; 23:151923920-151923920	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.562G>A; p.D188N; 23:151924226-151924226	skin	malignant_melanoma	Substitution - Missense
c.84A>G; p.A28A; 23:151923748-151923748	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.84A>G; p.A28A; 23:151923748-151923748	thyroid	other; neoplasm	Substitution - coding silent
c.650C>A; p.A217D; 23:151924314-151924314	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.590T>A; p.F197Y; 23:151924254-151924254	skin	malignant_melanoma	Substitution - Missense
c.789C>T; p.P263P; 23:151924453-151924453	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.367C>T; p.R123C; 23:151924031-151924031	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.49G>C; p.E17Q; 23:151923713-151923713	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.452T>A; p.I151N; 23:151924116-151924116	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.632C>A; p.A211E; 23:151924296-151924296	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.486C>A; p.I162I; 23:151924150-151924150	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.605T>C; p.L202P; 23:151924269-151924269	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.403_406GAAA>GAA; p.E135fs; 23:151924067-151924070	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Complex
c.403_406GAAA>GAA; p.E135fs; 23:151924067-151924070	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Complex
c.747A>C; p.Q249H; 23:151924411-151924411	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.234C>T; p.F78F; 23:151923898-151923898	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.507A>C; p.E169D; 23:151924171-151924171	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.266G>A; p.S89N; 23:151923930-151923930	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.507A>C; p.E169D; 23:151924171-151924171	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.675G>A; p.E225E; 23:151924339-151924339	skin	malignant_melanoma	Substitution - coding silent
c.36T>C; p.P12P; 23:151923700-151923700	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.896G>A; p.R299H; 23:151924560-151924560	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.896G>A; p.R299H; 23:151924560-151924560	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.777C>T; p.Y259Y; 23:151924441-151924441	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation