Cancer metastasis database

Annotation category 5

Gene information

Gene ID 4049
Symbol

LTA

Synonymous

LT|TNFB|TNFSF1

Full name

lymphotoxin alpha

Gene description

LT-alpha|TNF superfamily, member 1|TNF-beta|lymphotoxin-alpha|tumor necrosis factor beta|tumor necrosis factor ligand superfamily member 1

Cytoband

6p21.3

Gene type

protein-coding

Synonymous

MIM:153440; HGNC:HGNC:6709; Ensembl:ENSG00000226979; HPRD:01084; Vega:OTTHUMG00000031135

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.227C>T; p.S76L; 6:31573302-31573302

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.249G>A; p.T83T; 6:31573324-31573324

 skinmalignant_melanomaSubstitution - coding silent

c.90T>C; p.P30P; 6:31572832-31572832

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.541C>T; p.L181L; 6:31573616-31573616

 skinmalignant_melanomaSubstitution - coding silent

c.379_380insC; p.L129fs*6; 6:31573454-31573455

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.315C>T; p.G105G; 6:31573390-31573390

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.362C>T; p.S121F; 6:31573437-31573437

 skinmalignant_melanomaSubstitution - Missense

c.400G>T; p.E134*; 6:31573475-31573475

 pancreascarcinoma; acinar_carcinomaSubstitution - Nonsense

c.61C>T; p.L21F; 6:31572803-31572803

 skinmalignant_melanomaSubstitution - Missense

c.300G>C; p.L100L; 6:31573375-31573375

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.427C>G; p.P143A; 6:31573502-31573502

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.432C>T; p.F144F; 6:31573507-31573507

 skinmalignant_melanomaSubstitution - coding silent

c.569A>C; p.H190P; 6:31573644-31573644

 breastcarcinomaSubstitution - Missense

c.248C>T; p.T83M; 6:31573323-31573323

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.405C>T; p.V135V; 6:31573480-31573480

 skinmalignant_melanomaSubstitution - coding silent

c.610G>A; p.A204T; 6:31573685-31573685

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.295C>A; p.L99I; 6:31573370-31573370

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.498G>A; p.S166S; 6:31573573-31573573

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.327C>G; p.V109V; 6:31573402-31573402

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; diffuse_large_B_cell_lymphomaSubstitution - coding silent

c.285C>A; p.S95R; 6:31573360-31573360

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.250G>A; p.D84N; 6:31573325-31573325

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.250G>A; p.D84N; 6:31573325-31573325

 breastcarcinomaSubstitution - Missense

c.3G>A; p.M1I; 6:31572745-31572745

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.213C>T; p.P71P; 6:31573288-31573288

 skinmalignant_melanomaSubstitution - coding silent

c.564C>T; p.I188I; 6:31573639-31573639

 skinmalignant_melanomaSubstitution - coding silent

c.179C>A; p.T60N; 6:31573007-31573007

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.120C>T; p.L40L; 6:31572948-31572948

 skinmalignant_melanomaSubstitution - coding silent

c.64C>T; p.L22L; 6:31572806-31572806

 skinmalignant_melanomaSubstitution - coding silent

c.388T>C; p.Y130H; 6:31573463-31573463

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.613C>A; p.L205M; 6:31573688-31573688

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.594C>G; p.V198V; 6:31573669-31573669

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.594C>G; p.V198V; 6:31573669-31573669

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.594C>G; p.V198V; 6:31573669-31573669

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.594C>G; p.V198V; 6:31573669-31573669

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.535G>C; p.D179H; 6:31573610-31573610

 pancreascarcinomaSubstitution - Missense

c.538C>A; p.Q180K; 6:31573613-31573613

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.225C>G; p.N75K; 6:31573300-31573300

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.226T>C; p.S76P; 6:31573301-31573301

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.577C>A; p.L193I; 6:31573652-31573652

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.516G>A; p.A172A; 6:31573591-31573591

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.144C>A; p.A48A; 6:31572972-31572972

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.577C>T; p.L193F; 6:31573652-31573652

 skinmalignant_melanomaSubstitution - Missense

c.383C>A; p.P128Q; 6:31573458-31573458

 biliary_tract; gallbladdercarcinoma; adenocarcinomaSubstitution - Missense

c.351G>A; p.G117G; 6:31573426-31573426

 skinmalignant_melanomaSubstitution - coding silent

c.533G>T; p.G178V; 6:31573608-31573608

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.293C>T; p.S98F; 6:31573368-31573368

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.106C>T; p.P36S; 6:31572934-31572934

 skinmalignant_melanomaSubstitution - Missense

c.324C>T; p.F108F; 6:31573399-31573399

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent