lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3978
Symbol	LIG1
Synonymous	-
Full name	ligase I, DNA, ATP-dependent
Gene description	DNA ligase 1\|polydeoxyribonucleotide synthase [ATP] 1
Cytoband	19q13.2-q13.3
Gene type	protein-coding
Synonymous	MIM:126391; HGNC:HGNC:6598; Ensembl:ENSG00000105486; HPRD:00534; Vega:OTTHUMG00000183187

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1906C>A; p.Q636K; 19:48127936-48127936	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1228G>A; p.D410N; 19:48137548-48137548	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1251T>C; p.S417S; 19:48137525-48137525	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1796C>T; p.P599L; 19:48131101-48131101	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2456G>T; p.S819I; 19:48117765-48117765	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1834T>C; p.S612P; 19:48128008-48128008	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.540G>A; p.Q180Q; 19:48151266-48151266	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1711_1712GG>TT; p.G571L; 19:48132995-48132996	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.454A>G; p.K152E; 19:48153884-48153884	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1961A>T; p.Q654L; 19:48127320-48127320	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.2219A>G; p.H740R; 19:48122947-48122947	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.362G>A; p.R121H; 19:48157022-48157022	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1961A>T; p.Q654L; 19:48127320-48127320	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.778C>T; p.P260S; 19:48143962-48143962	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1921C>G; p.R641G; 19:48127921-48127921	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1120G>A; p.A374T; 19:48137656-48137656	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2629C>T; p.R877*; 19:48115920-48115920	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2629C>T; p.R877*; 19:48115920-48115920	skin	malignant_melanoma	Substitution - Nonsense
c.2290G>A; p.A764T; 19:48121265-48121265	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2346C>A; p.S782S; 19:48121209-48121209	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.953C>T; p.S318F; 19:48140105-48140105	skin	malignant_melanoma	Substitution - Missense
c.662C>T; p.P221L; 19:48150123-48150123	skin	malignant_melanoma	Substitution - Missense
c.1005C>G; p.L335L; 19:48140053-48140053	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.2076G>T; p.E692D; 19:48123247-48123247	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1861G>A; p.E621K; 19:48127981-48127981	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1877A>G; p.D626G; 19:48127965-48127965	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.52A>G; p.K18E; 19:48162317-48162317	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.2382C>T; p.C794C; 19:48121173-48121173	salivary_gland; tongue	carcinoma; adenoid_cystic_carcinoma	Substitution - coding silent
c.2651C>T; p.P884L; 19:48115898-48115898	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2271G>A; p.L757L; 19:48121284-48121284	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2122G>A; p.A708T; 19:48123201-48123201	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.154C>T; p.P52S; 19:48161461-48161461	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1969T>G; p.L657V; 19:48127312-48127312	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1969T>G; p.L657V; 19:48127312-48127312	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2446G>A; p.V816M; 19:48117775-48117775	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1980C>T; p.F660F; 19:48127301-48127301	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1424A>T; p.E475V; 19:48135779-48135779	skin	malignant_melanoma	Substitution - Missense
c.999C>T; p.L333L; 19:48140059-48140059	breast	carcinoma	Substitution - coding silent
c.1959G>T; p.V653V; 19:48127322-48127322	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2562C>G; p.I854M; 19:48117659-48117659	breast	carcinoma	Substitution - Missense
c.1114G>A; p.E372K; 19:48137662-48137662	skin	malignant_melanoma	Substitution - Missense
c.582G>T; p.E194D; 19:48150203-48150203	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.370+3G>C; p.?; 19:48157011-48157011	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Unknown
c.2045T>C; p.L682P; 19:48123278-48123278	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.968C>T; p.S323L; 19:48140090-48140090	skin	malignant_melanoma	Substitution - Missense
c.2304G>T; p.R768R; 19:48121251-48121251	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.108G>A; p.K36K; 19:48161507-48161507	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1227C>T; p.R409R; 19:48137549-48137549	pancreas	carcinoma	Substitution - coding silent
c.1227C>T; p.R409R; 19:48137549-48137549	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.698-1G>T; p.?; 19:48149842-48149842	lung	carcinoma; adenocarcinoma	Unknown
c.548C>T; p.T183M; 19:48151258-48151258	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2406T>C; p.D802D; 19:48119170-48119170	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.2406T>C; p.D802D; 19:48119170-48119170	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.2364G>A; p.E788E; 19:48121191-48121191	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2029_2030insC; p.R677fs*54; 19:48123293-48123294	lung	carcinoma; non_small_cell_carcinoma	Insertion - Frameshift
c.508G>A; p.A170T; 19:48151298-48151298	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1482G>A; p.T494T; 19:48135721-48135721	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.681G>C; p.T227T; 19:48150104-48150104	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2620C>T; p.R874W; 19:48115929-48115929	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.357G>A; p.P119P; 19:48157027-48157027	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.11G>A; p.S4N; 19:48165556-48165556	breast	carcinoma	Substitution - Missense
c.409C>T; p.L137L; 19:48153929-48153929	skin	malignant_melanoma	Substitution - coding silent
c.1471G>A; p.A491T; 19:48135732-48135732	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2325C>T; p.Y775Y; 19:48121230-48121230	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.703delC; p.R235fs*9; 19:48149836-48149836	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.392G>A; p.R131Q; 19:48153946-48153946	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2199C>T; p.Y733Y; 19:48122967-48122967	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1205C>T; p.S402F; 19:48137571-48137571	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2523G>A; p.V841V; 19:48117698-48117698	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1490A>G; p.E497G; 19:48135713-48135713	thyroid	other; neoplasm	Substitution - Missense
c.1711G>A; p.G571R; 19:48132996-48132996	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.421A>G; p.S141G; 19:48153917-48153917	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2352C>T; p.D784D; 19:48121203-48121203	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2518G>T; p.A840S; 19:48117703-48117703	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2636G>C; p.R879P; 19:48115913-48115913	skin	malignant_melanoma	Substitution - Missense
c.687C>T; p.S229S; 19:48150098-48150098	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1252G>A; p.A418T; 19:48137524-48137524	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.455A>G; p.K152R; 19:48153883-48153883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.455A>G; p.K152R; 19:48153883-48153883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.455A>G; p.K152R; 19:48153883-48153883	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.455A>G; p.K152R; 19:48153883-48153883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.455A>G; p.K152R; 19:48153883-48153883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.455A>G; p.K152R; 19:48153883-48153883	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2279T>C; p.V760A; 19:48121276-48121276	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2190T>C; p.D730D; 19:48122976-48122976	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.455A>G; p.K152R; 19:48153883-48153883	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.455A>G; p.K152R; 19:48153883-48153883	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.455A>G; p.K152R; 19:48153883-48153883	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.455A>G; p.K152R; 19:48153883-48153883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2547C>T; p.L849L; 19:48117674-48117674	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1184C>A; p.P395Q; 19:48137592-48137592	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1261G>T; p.A421S; 19:48137078-48137078	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.576A>C; p.K192N; 19:48150209-48150209	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.504A>C; p.E168D; 19:48151302-48151302	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2112C>T; p.I704I; 19:48123211-48123211	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1936G>T; p.V646L; 19:48127345-48127345	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.377A>C; p.K126T; 19:48153961-48153961	skin	malignant_melanoma	Substitution - Missense
c.2600G>A; p.G867D; 19:48115949-48115949	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2600G>A; p.G867D; 19:48115949-48115949	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1669C>T; p.R557C; 19:48133038-48133038	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1479G>A; p.K493K; 19:48135724-48135724	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.990C>A; p.V330V; 19:48140068-48140068	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.436A>T; p.R146*; 19:48153902-48153902	kidney	other; neoplasm	Substitution - Nonsense
c.246G>T; p.K82N; 19:48157138-48157138	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2206G>A; p.A736T; 19:48122960-48122960	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1242C>T; p.L414L; 19:48137534-48137534	breast	carcinoma	Substitution - coding silent
c.1310C>G; p.S437*; 19:48137029-48137029	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2206G>A; p.A736T; 19:48122960-48122960	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1812C>T; p.R604R; 19:48131085-48131085	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1848C>T; p.F616F; 19:48127994-48127994	breast	carcinoma	Substitution - coding silent
c.478C>G; p.P160A; 19:48151328-48151328	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1761C>T; p.F587F; 19:48131136-48131136	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.179C>T; p.A60V; 19:48161436-48161436	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1149C>T; p.A383A; 19:48137627-48137627	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1149C>T; p.A383A; 19:48137627-48137627	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1149C>T; p.A383A; 19:48137627-48137627	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1149C>T; p.A383A; 19:48137627-48137627	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.897C>A; p.I299I; 19:48143560-48143560	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1149C>T; p.A383A; 19:48137627-48137627	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1254+2_1254+9delTGAGTGGG; p.?; 19:48137513-48137520	stomach	carcinoma; intestinal_adenocarcinoma	Unknown
c.457G>A; p.E153K; 19:48153881-48153881	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.969G>A; p.S323S; 19:48140089-48140089	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1670G>A; p.R557H; 19:48133037-48133037	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.514G>C; p.E172Q; 19:48151292-48151292	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1237A>T; p.R413W; 19:48137539-48137539	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.488G>A; p.S163N; 19:48151318-48151318	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2517C>T; p.S839S; 19:48117704-48117704	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1168C>T; p.Q390*; 19:48137608-48137608	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2330G>A; p.G777D; 19:48121225-48121225	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.717C>G; p.V239V; 19:48149822-48149822	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1502T>C; p.M501T; 19:48135701-48135701	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1887G>T; p.K629N; 19:48127955-48127955	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.681G>A; p.T227T; 19:48150104-48150104	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1743C>T; p.G581G; 19:48131154-48131154	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1342G>A; p.G448R; 19:48136115-48136115	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2353G>A; p.E785K; 19:48121202-48121202	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.880C>T; p.R294W; 19:48143577-48143577	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.904G>A; p.V302M; 19:48143553-48143553	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.619A>T; p.T207S; 19:48150166-48150166	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1836G>A; p.S612S; 19:48128006-48128006	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.319G>A; p.D107N; 19:48157065-48157065	urinary_tract; bladder	carcinoma	Substitution - Missense
c.729G>A; p.V243V; 19:48149810-48149810	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.165G>T; p.R55S; 19:48161450-48161450	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.520G>A; p.E174K; 19:48151286-48151286	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1835C>T; p.S612L; 19:48128007-48128007	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1835C>T; p.S612L; 19:48128007-48128007	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2073C>T; p.G691G; 19:48123250-48123250	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1110G>T; p.R370R; 19:48137666-48137666	breast	carcinoma	Substitution - coding silent
c.1104C>T; p.S368S; 19:48137672-48137672	skin	malignant_melanoma	Substitution - coding silent
c.1045G>A; p.V349M; 19:48140013-48140013	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1045G>A; p.V349M; 19:48140013-48140013	pancreas	carcinoma	Substitution - Missense
c.394A>G; p.T132A; 19:48153944-48153944	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.664C>T; p.R222C; 19:48150121-48150121	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2464C>T; p.P822S; 19:48117757-48117757	skin	malignant_melanoma	Substitution - Missense
c.279C>T; p.P93P; 19:48157105-48157105	skin	malignant_melanoma	Substitution - coding silent
c.155C>T; p.P52L; 19:48161460-48161460	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.751C>G; p.P251A; 19:48149788-48149788	breast	carcinoma	Substitution - Missense
c.1836G>T; p.S612S; 19:48128006-48128006	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.276G>A; p.P92P; 19:48157108-48157108	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1880G>A; p.R627Q; 19:48127962-48127962	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2376C>A; p.A792A; 19:48121179-48121179	breast	carcinoma	Substitution - coding silent
c.374G>T; p.R125L; 19:48153964-48153964	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2345C>T; p.S782F; 19:48121210-48121210	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.901G>A; p.E301K; 19:48143556-48143556	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1911G>A; p.V637V; 19:48127931-48127931	skin	malignant_melanoma	Substitution - coding silent
c.779C>T; p.P260L; 19:48143961-48143961	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1755G>T; p.K585N; 19:48131142-48131142	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2052G>T; p.E684D; 19:48123271-48123271	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1695C>G; p.C565W; 19:48133012-48133012	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.549G>A; p.T183T; 19:48151257-48151257	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.524G>A; p.G175E; 19:48151282-48151282	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.661C>T; p.P221S; 19:48150124-48150124	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1731C>T; p.H577H; 19:48131166-48131166	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1045G>C; p.V349L; 19:48140013-48140013	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.920G>A; p.R307Q; 19:48140138-48140138	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1731C>T; p.H577H; 19:48131166-48131166	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.588G>C; p.P196P; 19:48150197-48150197	liver	carcinoma	Substitution - coding silent
c.588G>C; p.P196P; 19:48150197-48150197	liver	carcinoma	Substitution - coding silent
c.1065C>G; p.L355L; 19:48139993-48139993	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.476C>A; p.T159N; 19:48151330-48151330	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.304A>C; p.N102H; 19:48157080-48157080	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.184C>A; p.R62R; 19:48161431-48161431	skin	malignant_melanoma	Substitution - coding silent
c.1019C>T; p.P340L; 19:48140039-48140039	skin; extremity	malignant_melanoma	Substitution - Missense
c.1121C>T; p.A374V; 19:48137655-48137655	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.88G>T; p.E30*; 19:48162281-48162281	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2575C>T; p.R859W; 19:48117646-48117646	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.2191G>A; p.A731T; 19:48122975-48122975	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.692T>G; p.F231C; 19:48150093-48150093	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.78T>C; p.N26N; 19:48162291-48162291	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.139T>A; p.S47T; 19:48161476-48161476	lung	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation