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Cancer metastasis database

Annotation category 5

Gene information

Gene ID 3978
Symbol

LIG1

Synonymous

-

Full name

ligase I, DNA, ATP-dependent

Gene description

DNA ligase 1|polydeoxyribonucleotide synthase [ATP] 1

Cytoband

19q13.2-q13.3

Gene type

protein-coding

Synonymous

MIM:126391; HGNC:HGNC:6598; Ensembl:ENSG00000105486; HPRD:00534; Vega:OTTHUMG00000183187

Pathway and disease

Pathways and Diseases

Detail

Pathway

Early Phase of HIV Life Cycle;PID Reactome;500724

Pathway

Cell Cycle, Mitotic;Reactome;REACT:152

Pathway

Processive synthesis on the C-strand of the telomere;PID Reactome;500671

Pathway

DNA Repair;Reactome;REACT:216

Pathway

Base excision repair;KEGG PATHWAY;hsa03410

Pathway

Chromosome Maintenance;Reactome;REACT:22172

Pathway

Mismatch repair;KEGG PATHWAY;hsa03430

Pathway

DNA replication;KEGG PATHWAY;hsa03030

Pathway

Resolution of D-loop structures through Holliday junction intermediates;PID Reactome;500052

Pathway

DNA Replication;Reactome;REACT:383

Pathway

Processive synthesis on the lagging strand;PID Reactome;500900

Pathway

Resolution of AP sites via the multiple-nucleotide patch replacement pathway;PID Reactome;500033

Pathway

Removal of DNA patch containing abasic residue;PID Reactome;500945

Pathway

Nucleotide excision repair;KEGG PATHWAY;hsa03420

Pathway

Gap-filling DNA repair synthesis and ligation in GG-NER;PID Reactome;500062

Pathway

Gap-filling DNA repair synthesis and ligation in TC-NER;PID Reactome;500067

Disease

DNA ligase I deficiency;OMIM

Disease

Immune system diseases;KEGG DISEASE

Disease

head and neck cancer lung cancer;GAD

Disease

DNA repair defect;KEGG DISEASE;H00094

Disease

CANCER;GAD

Disease

Primary immunodeficiency;KEGG DISEASE

Sequence Information

Nucleotide Sequence

>3978 : length: 4410
CTCGCGGGGGCGCTTCCACCGATTCCTCCTCTTTCCCTGCCAGTCACTCCTCAGACCCTCAGCCACACCCGCTCATCCAGGGCGAGGGAAAGCGCGGGCATTTTCCCAGTGTGCTCTGCG
GGAGGGCTCGCCCCACTTCACCCCTTTTCCCGCCCTCCTCCCATTCGGGAGACTACGACTCCCAGTGTCCTCCGCGCGACGGCGGCGGTGCGGACGGTGCCCAGGTCCCGCCCCTAGGCT
CTGCCCCGCCCCCGCCCGCAGACGTCTGCGCGCGAATGCCGTGGCGCGAACTTGGGACTGCAGAGGCGCGCCTGGCGGATCTGAGTGTGTTGCCCGGGCAGCGGCGCGCGGGACCAACGC
AAGGAGCAGCTGACAGACGAAGAAAAGTGCTGGACAGGAAGGGAGAATTCTGACGCCAACATGCAGCGAAGTATCATGTCATTTTTCCACCCCAAGAAAGAGGGTAAAGCAAAGAAGCCT
GAGAAGGAGGCATCCAATAGCAGCAGAGAGACGGAGCCCCCTCCAAAGGCGGCACTGAAGGAGTGGAATGGAGTGGTGTCCGAGAGTGACTCTCCGGTGAAGAGGCCAGGGAGGAAGGCG
GCCCGGGTCCTGGGCAGCGAAGGGGAAGAGGAGGATGAAGCCCTTAGCCCTGCTAAAGGCCAGAAGCCTGCCCTGGACTGCTCACAGGTCTCCCCGCCCCGTCCTGCCACATCTCCTGAG
AACAATGCTTCCCTCTCTGACACCTCTCCCATGGACAGTTCCCCATCAGGGATTCCGAAGCGTCGCACAGCTCGGAAGCAGCTCCCGAAACGGACCATTCAGGAAGTCCTGGAAGAGCAG
AGTGAGGACGAGGACAGAGAAGCCAAGAGGAAGAAGGAGGAGGAAGAGGAGACCCCGAAAGAAAGCCTCACAGAGGCTGAAGTGGCCACAGAGAAGGAAGGAGAAGACGGGGACCAGCCC
ACCACGCCTCCCAAGCCCCTAAAGACCTCCAAAGCAGAGACCCCGACGGAAAGCGTTTCAGAGCCTGAGGTGGCCACGAAGCAGGAACTGCAGGAGGAGGAAGAGCAGACCAAGCCTCCC
CGCAGAGCTCCCAAGACGCTCAGCAGCTTCTTCACCCCCCGGAAGCCAGCAGTCAAAAAAGAAGTGAAGGAAGAGGAGCCAGGGGCTCCAGGAAAGGAGGGAGCTGCTGAGGGACCCCTG
GATCCATCTGGTTACAATCCTGCCAAGAACAACTATCATCCCGTGGAAGATGCCTGCTGGAAACCGGGCCAGAAGGTTCCTTACCTGGCTGTGGCCCGGACGTTTGAGAAGATCGAGGAG
GTGTCTGCTCGGCTCCGGATGGTGGAGACGCTGAGCAACTTGCTGCGCTCCGTGGTGGCCCTGTCGCCTCCAGACCTCCTCCCTGTCCTCTACCTCAGCCTCAACCACCTTGGGCCACCC
CAGCAGGGCCTGGAGCTTGGCGTGGGTGATGGTGTCCTTCTCAAGGCAGTGGCCCAGGCCACAGGTCGGCAGCTGGAGTCCGTCCGGGCTGAGGCAGCCGAGAAAGGCGACGTGGGGCTG
GTGGCCGAGAACAGCCGCAGCACCCAGAGGCTCATGCTGCCACCACCTCCGCTCACTGCCTCCGGGGTCTTCAGCAAGTTCCGCGACATCGCCAGGCTCACTGGCAGTGCTTCCACAGCC
AAGAAGATAGACATCATCAAAGGCCTCTTTGTGGCCTGCCGCCACTCAGAAGCCCGGTTCATCGCTAGGTCCCTGAGCGGACGGCTGCGCCTTGGGCTGGCAGAGCAGTCGGTGCTGGCT
GCCCTCTCCCAGGCAGTGAGCCTCACGCCCCCGGGCCAAGAATTCCCACCAGCCATGGTGGATGCTGGGAAGGGCAAGACAGCAGAGGCCAGAAAGACGTGGCTGGAGGAGCAAGGCATG
ATCCTGAAGCAGACGTTCTGCGAGGTTCCCGACCTGGACCGAATTATCCCCGTGCTGCTGGAGCACGGCCTGGAACGTCTCCCGGAGCACTGCAAGCTGAGCCCAGGGATTCCCCTGAAA
CCAATGTTGGCCCATCCCACCCGGGGCATCAGCGAGGTCCTGAAACGCTTTGAGGAGGCAGCTTTCACCTGCGAATACAAATATGACGGGCAGAGGGCACAGATCCACGCCCTGGAAGGC
GGGGAGGTGAAGATCTTCAGCAGGAATCAGGAAGACAACACTGGGAAGTACCCGGACATCATCAGCCGCATCCCCAAGATTAAACTCCCATCGGTCACATCCTTCATCCTGGACACCGAA
GCCGTGGCTTGGGACCGGGAAAAGAAGCAGATCCAGCCATTCCAAGTGCTCACCACCCGCAAACGCAAGGAGGTGGATGCGTCTGAGATCCAGGTGCAGGTGTGTTTGTACGCCTTCGAC
CTCATCTACCTCAATGGAGAGTCCCTGGTACGTGAGCCCCTTTCCCGGCGCCGGCAGCTGCTCCGGGAGAACTTTGTGGAGACAGAGGGCGAGTTTGTCTTCGCCACCTCCCTGGACACC
AAGGACATCGAGCAGATCGCCGAGTTCCTGGAGCAGTCAGTGAAAGACTCCTGCGAGGGGCTGATGGTGAAGACCCTGGATGTTGATGCCACCTACGAGATCGCCAAGAGATCGCACAAC
TGGCTCAAGCTGAAGAAGGACTACCTTGATGGCGTGGGTGACACCCTGGACCTGGTGGTGATCGGCGCCTACCTGGGCCGGGGGAAGCGGGCCGGCCGGTACGGGGGCTTCCTGCTGGCC
TCCTACGACGAGGACAGTGAGGAGCTGCAGGCCATATGCAAGGTCCTGGGGAACTGGGGCTGATGGCAGAAGCAGGAGGGAAGGAGATTAGACTCCCGGGGGTATTTCCTATTGCACAAC
CCAGACCGAGGGGTGCTCACATCCCCCTGTGAAGGATCCGTTCTCCCCAGTTTTTATTTACTTTTTCTGGTTCTATGAGCAACTCTTGCTTCATATAGAAAAACAGGCTGGGATAGAAAG
ATGTCAGGAATGTGTGTCAGTGAGAGATTGAGATTAGCTACAAATAGTGGTGGCTCACATAAGAAAAGAATTTTTTTGTTATGAAATGAGAAGTGTGGAGGGGGCAGTCTGATGCCATTA
GGGATTCAGGTTCCTCCTCTCCCCACATTTTTTTTTGTCCCCACATTTTTTTTTTCTGCCATGTGCCTCTGGCCTCATCATCACAATGTGGCTGCAGGAGTTCCAGCCCTCATGGCCATG
CCTGCTCCACGCACCAGGGAAGAGCAAAGGGGGTTGGACCCTGAGTCAGCCTCAGCCAGTGAACACCTTCTGCTCAAGTTCTGTTGCTCATCACTTTGCTCCATGGCTCACCCCTAGCTG
CAAGGAATTCTGGGAAATGTAAAGTGATTTACTTTTTTTCAAGTTAAAGTTTTTCTTAAAGCTGTGCACATTTTGGACTAGATTTTCTTACGTATTTCCTATATTCCCCTCTCCAACAAA
TTTGGGTCTTTTGCCACAGAAACAGAACAAAATATCACCTAGAATCGTACCACCCAGAGACACGCAGTAGTGACATTTGAGGGAATGTTTTATTTACATTTTTGCAAAGTTGTGATCCTT
CTCTATGAGTAATTTTCTTTTCTGCCTTTTTACCCTGGAAGTACTTTGTTTTCAGTGTTGTATATGCCCTTAAGCAATATGGCAACAGGACCTGAATGCCCGCACAAGAGTTTTCAAGTG
CTGTGCCCCATAGCACATAGTGCTGTGTCCTGAACCAGCTCCCCGTGGCTGTGTGGGGAAGTTGTTGCCGGCTTTGTTCTGATGGCTTGGAACTGGCTTCAGTGATGAGGAGCTGGAGGA
GCATCACCAGAGCCTCAAGGCGCTGGTGCTGCCCAGCCCACGCCCTTACGTGCGGATAGATGGCGCTGTGATTCCCGACCACTGGCTGGACCCCAGCGCTGTGTGGGAGGTGAAGTGCGC
TGACCTCTCCCTCTCTCCCATCTACCCTGCTGCGCGGGGCCTGGTGGATAGTGACAAGGGCATCTCCCTTCGCTTCCCTCGGTTTATTCGAGTCCGTGAAGACAAGCAGCCGGAGCAGGC
CACCACCAGTGCTCAGGTGGCCTGTTTGTACCGGAAGCAAAGTCAGATTCAGAACCAACAAGGCGAGGACTCAGGCTCTGACCCTGAAGATACCTACTAAGCCCTCGCCCTCCTAGGGCC
TGGGTACAGGGCATGAGTTGGACGGACCCCAGGGTTATTATTGCCTTTGCTTTTTAGCAAATCTGCTGTGGCAGGCTGTGGATTTTGAGAGTCAGGGGAGGGGTGTGTGTGTGAGGGGGT
GGCTTACTCCGGAGTCTGGGATTCATCCCGTCATTTCTTTCAATAAATAATTATTGGATAGCTAAAAAAAAAAAAAAAAAAAAAAAAAAA

Protein Sequence

>3978 : length: 919
MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPK
RRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVK
KEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAM
VDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPD
IISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCE
GLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSA
VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGEDSGSDPEDTY