lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3654
Symbol	IRAK1
Synonymous	IRAK\|pelle
Full name	interleukin-1 receptor-associated kinase 1
Gene description	IRAK-1\|Pelle homolog
Cytoband	Xq28
Gene type	protein-coding
Synonymous	MIM:300283; HGNC:HGNC:6112; Ensembl:ENSG00000184216; HPRD:02235; Vega:OTTHUMG00000024228

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1162C>A; p.L388M; 23:154016511-154016511	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1997G>A; p.R666Q; 23:154012612-154012612	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.590C>T; p.P197L; 23:154018738-154018738	skin	malignant_melanoma	Substitution - Missense
c.889G>A; p.E297K; 23:154018026-154018026	skin; mucosal	malignant_melanoma	Substitution - Missense
c.2074C>T; p.L692F; 23:154012535-154012535	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.2074C>T; p.L692F; 23:154012535-154012535	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1830G>A; p.L610L; 23:154013143-154013143	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.920G>T; p.C307F; 23:154017057-154017057	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.280C>T; p.R94C; 23:154019455-154019455	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1892G>T; p.W631L; 23:154013081-154013081	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1175_1176CC>TT; p.P392L; 23:154016497-154016498	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1408G>A; p.A470T; 23:154014173-154014173	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1612A>G; p.I538V; 23:154013361-154013361	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.849C>A; p.F283L; 23:154018066-154018066	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.399G>T; p.R133R; 23:154019234-154019234	breast	carcinoma	Substitution - coding silent
c.1768G>T; p.E590*; 23:154013205-154013205	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Nonsense
c.1409C>T; p.A470V; 23:154014172-154014172	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.513G>A; p.P171P; 23:154019002-154019002	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1759G>A; p.E587K; 23:154013214-154013214	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.510A>C; p.P170P; 23:154019005-154019005	breast	carcinoma	Substitution - coding silent
c.234C>T; p.A78A; 23:154019501-154019501	lung	carcinoid-endocrine_tumour; atypical	Substitution - coding silent
c.1873A>G; p.T625A; 23:154013100-154013100	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.474C>T; p.L158L; 23:154019041-154019041	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1984A>G; p.I662V; 23:154012625-154012625	breast	carcinoma	Substitution - Missense
c.483C>T; p.V161V; 23:154019032-154019032	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.443C>T; p.P148L; 23:154019072-154019072	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1579G>T; p.G527W; 23:154013394-154013394	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.369A>C; p.A123A; 23:154019264-154019264	pancreas	carcinoma	Substitution - coding silent
c.1641C>A; p.Y547*; 23:154013332-154013332	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.397_398insC; p.R133fs*25; 23:154019235-154019236	large_intestine; colon	NS	Insertion - Frameshift
c.1744C>T; p.P582S; 23:154013229-154013229	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1263G>C; p.Q421H; 23:154016071-154016071	breast	carcinoma; lobular_carcinoma	Substitution - Missense
c.1263G>C; p.Q421H; 23:154016071-154016071	breast	carcinoma; lobular_carcinoma	Substitution - Missense
c.1442G>A; p.R481K; 23:154014139-154014139	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1263G>C; p.Q421H; 23:154016071-154016071	breast	carcinoma	Substitution - Missense
c.1028+2T>C; p.?; 23:154016947-154016947	stomach	carcinoma; adenocarcinoma	Unknown
c.1564C>T; p.Q522*; 23:154013409-154013409	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.938C>T; p.P313L; 23:154017039-154017039	skin	malignant_melanoma	Substitution - Missense
c.1936G>A; p.A646T; 23:154012673-154012673	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1315G>T; p.E439*; 23:154014266-154014266	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1925T>C; p.V642A; 23:154013048-154013048	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1961C>T; p.S654L; 23:154012648-154012648	pancreas	carcinoma	Substitution - Missense
c.1971A>G; p.P657P; 23:154012638-154012638	liver	carcinoma	Substitution - coding silent
c.1615C>T; p.P539S; 23:154013358-154013358	skin	malignant_melanoma	Substitution - Missense
c.1971A>G; p.P657P; 23:154012638-154012638	liver	carcinoma	Substitution - coding silent
c.630C>A; p.H210Q; 23:154018698-154018698	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1595C>T; p.S532L; 23:154013378-154013378	thyroid	other; neoplasm	Substitution - Missense
c.325C>T; p.P109S; 23:154019308-154019308	skin	malignant_melanoma	Substitution - Missense
c.1595C>T; p.S532L; 23:154013378-154013378	thyroid	other; neoplasm	Substitution - Missense
c.1626G>A; p.P542P; 23:154013347-154013347	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.340A>G; p.T114A; 23:154019293-154019293	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1141A>T; p.T381S; 23:154016532-154016532	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1973C>T; p.P658L; 23:154012636-154012636	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1319A>G; p.E440G; 23:154014262-154014262	skin; scalp	malignant_melanoma	Substitution - Missense
c.1973C>T; p.P658L; 23:154012636-154012636	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1026G>C; p.K342N; 23:154016951-154016951	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1026G>C; p.K342N; 23:154016951-154016951	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1318G>A; p.E440K; 23:154014263-154014263	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1979T>C; p.I660T; 23:154012630-154012630	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1544A>G; p.Y515C; 23:154013429-154013429	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.1602C>A; p.A534A; 23:154013371-154013371	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1277C>T; p.T426M; 23:154016057-154016057	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.675C>T; p.C225C; 23:154018653-154018653	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2098G>A; p.D700N; 23:154011900-154011900	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.2098G>A; p.D700N; 23:154011900-154011900	pancreas	carcinoma	Substitution - Missense
c.1352G>T; p.S451I; 23:154014229-154014229	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.671G>A; p.G224E; 23:154018657-154018657	skin	malignant_melanoma	Substitution - Missense
c.880G>A; p.G294S; 23:154018035-154018035	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.963T>A; p.G321G; 23:154017014-154017014	breast	carcinoma	Substitution - coding silent
c.1969C>T; p.P657S; 23:154012640-154012640	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1997G>T; p.R666L; 23:154012612-154012612	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1750C>A; p.Q584K; 23:154013223-154013223	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.60C>A; p.Y20*; 23:154019753-154019753	thyroid	other; neoplasm	Substitution - Nonsense
c.1235T>C; p.V412A; 23:154016438-154016438	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1234G>A; p.V412M; 23:154016439-154016439	central_nervous_system; brain	glioma	Substitution - Missense
c.1234G>A; p.V412M; 23:154016439-154016439	central_nervous_system; brain	glioma	Substitution - Missense
c.1642G>A; p.V548M; 23:154013331-154013331	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2068A>G; p.S690G; 23:154012541-154012541	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2068A>G; p.S690G; 23:154012541-154012541	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.2068A>G; p.S690G; 23:154012541-154012541	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.2068A>G; p.S690G; 23:154012541-154012541	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.944G>A; p.R315Q; 23:154017033-154017033	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1962G>A; p.S654S; 23:154012647-154012647	breast	carcinoma	Substitution - coding silent
c.618C>A; p.S206S; 23:154018710-154018710	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1471C>G; p.L491V; 23:154014110-154014110	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1579G>A; p.G527R; 23:154013394-154013394	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.282T>C; p.R94R; 23:154019453-154019453	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1359G>C; p.Q453H; 23:154014222-154014222	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.34G>A; p.A12T; 23:154019779-154019779	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1619delC; p.P540fs*53; 23:154013354-154013354	oesophagus	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1619delC; p.P540fs*53; 23:154013354-154013354	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1619delC; p.P540fs*53; 23:154013354-154013354	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1328A>C; p.E443A; 23:154014253-154014253	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.895C>T; p.R299C; 23:154018020-154018020	skin	malignant_melanoma	Substitution - Missense
c.838C>T; p.Q280*; 23:154018077-154018077	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.331C>T; p.P111S; 23:154019302-154019302	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1887G>C; p.S629S; 23:154013086-154013086	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1457C>T; p.P486L; 23:154014124-154014124	NS	malignant_melanoma	Substitution - Missense
c.441T>C; p.F147F; 23:154019074-154019074	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.910-7A>G; p.?; 23:154017074-154017074	liver	carcinoma	Unknown
c.308A>C; p.H103P; 23:154019325-154019325	pancreas	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation