lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3577
Symbol	CXCR1
Synonymous	C-C\|C-C-CKR-1\|CD128\|CD181\|CDw128a\|CKR-1\|CMKAR1\|IL8R1\|IL8RA\|IL8RBA
Full name	chemokine (C-X-C motif) receptor 1
Gene description	C-X-C chemokine receptor type 1\|CXC-R1\|CXCR-1\|IL-8 receptor type 1\|IL-8R A\|high affinity interleukin-8 receptor A\|interleukin 8 receptor, alpha\|interleukin-8 receptor type 1\|interleukin-8 receptor type A
Cytoband	2q35
Gene type	protein-coding
Synonymous	MIM:146929; HGNC:HGNC:6026; Ensembl:ENSG00000163464; HPRD:00908; Vega:OTTHUMG00000133108

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.948C>T; p.F316F; 2:218164264-218164264	skin	malignant_melanoma	Substitution - coding silent
c.948C>T; p.F316F; 2:218164264-218164264	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.997C>T; p.R333C; 2:218164215-218164215	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.932A>C; p.N311T; 2:218164280-218164280	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.431G>A; p.R144H; 2:218164781-218164781	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.879G>A; p.L293L; 2:218164333-218164333	skin	malignant_melanoma	Substitution - coding silent
c.553C>T; p.P185S; 2:218164659-218164659	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.508C>T; p.P170S; 2:218164704-218164704	skin	malignant_melanoma	Substitution - Missense
c.970G>A; p.G324S; 2:218164242-218164242	skin; mucosal	malignant_melanoma	Substitution - Missense
c.888C>T; p.L296L; 2:218164324-218164324	skin	malignant_melanoma	Substitution - coding silent
c.538C>G; p.P180A; 2:218164674-218164674	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.672C>T; p.F224F; 2:218164540-218164540	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.988T>G; p.F330V; 2:218164224-218164224	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.126G>A; p.V42V; 2:218165086-218165086	skin	malignant_melanoma	Substitution - coding silent
c.608G>A; p.R203Q; 2:218164604-218164604	central_nervous_system; brainstem	glioma; astrocytoma_Grade_II	Substitution - Missense
c.608G>A; p.R203Q; 2:218164604-218164604	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.608G>A; p.R203Q; 2:218164604-218164604	prostate	carcinoma	Substitution - Missense
c.835C>T; p.R279C; 2:218164377-218164377	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.904C>A; p.P302T; 2:218164308-218164308	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.177G>C; p.L59L; 2:218165035-218165035	pancreas	carcinoma	Substitution - coding silent
c.835C>T; p.R279C; 2:218164377-218164377	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.208G>T; p.G70C; 2:218165004-218165004	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.637G>A; p.V213M; 2:218164575-218164575	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.637G>A; p.V213M; 2:218164575-218164575	central_nervous_system; brain	glioma	Substitution - Missense
c.808A>G; p.T270A; 2:218164404-218164404	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.571C>A; p.L191M; 2:218164641-218164641	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.571C>A; p.L191M; 2:218164641-218164641	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.768G>T; p.L256L; 2:218164444-218164444	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.911T>C; p.I304T; 2:218164301-218164301	breast	carcinoma	Substitution - Missense
c.998G>A; p.R333H; 2:218164214-218164214	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.798C>T; p.T266T; 2:218164414-218164414	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.31G>A; p.D11N; 2:218165181-218165181	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.211C>T; p.R71C; 2:218165001-218165001	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.155T>G; p.L52R; 2:218165057-218165057	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.937C>T; p.R313C; 2:218164275-218164275	skin	malignant_melanoma	Substitution - Missense
c.985G>A; p.E329K; 2:218164227-218164227	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.341C>G; p.S114*; 2:218164871-218164871	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.797C>T; p.T266I; 2:218164415-218164415	skin	malignant_melanoma	Substitution - Missense
c.686T>A; p.L229Q; 2:218164526-218164526	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.289G>A; p.A97T; 2:218164923-218164923	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.354A>C; p.E118D; 2:218164858-218164858	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.226G>A; p.V76I; 2:218164986-218164986	large_intestine; colon	NS	Substitution - Missense
c.430C>T; p.R144C; 2:218164782-218164782	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.280A>G; p.I94V; 2:218164932-218164932	thyroid	carcinoma	Substitution - Missense
c.538C>T; p.P180S; 2:218164674-218164674	skin	malignant_melanoma	Substitution - Missense
c.129C>T; p.I43I; 2:218165083-218165083	skin	malignant_melanoma	Substitution - coding silent
c.850G>T; p.G284C; 2:218164362-218164362	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.770C>A; p.P257H; 2:218164442-218164442	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.385G>A; p.A129T; 2:218164827-218164827	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.624C>G; p.T208T; 2:218164588-218164588	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.680G>A; p.R227H; 2:218164532-218164532	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.124G>T; p.V42L; 2:218165088-218165088	liver	carcinoma	Substitution - Missense
c.124G>T; p.V42L; 2:218165088-218165088	liver	carcinoma	Substitution - Missense
c.931A>C; p.N311H; 2:218164281-218164281	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.325C>T; p.L109L; 2:218164887-218164887	skin	malignant_melanoma	Substitution - coding silent
c.97G>A; p.E33K; 2:218165115-218165115	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.523C>T; p.R175C; 2:218164689-218164689	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.926G>A; p.G309D; 2:218164286-218164286	prostate	carcinoma	Substitution - Missense
c.217G>A; p.V73I; 2:218164995-218164995	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.45A>G; p.L15L; 2:218165167-218165167	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.971G>A; p.G324D; 2:218164241-218164241	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.330C>T; p.C110C; 2:218164882-218164882	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.679C>T; p.R227C; 2:218164533-218164533	pancreas	carcinoma	Substitution - Missense
c.1026G>A; p.S342S; 2:218164186-218164186	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1026G>A; p.S342S; 2:218164186-218164186	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.463T>C; p.F155L; 2:218164749-218164749	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.601G>C; p.V201L; 2:218164611-218164611	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.532T>A; p.Y178N; 2:218164680-218164680	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.318C>G; p.G106G; 2:218164894-218164894	breast	carcinoma	Substitution - coding silent
c.836G>A; p.R279H; 2:218164376-218164376	breast	carcinoma	Substitution - Missense
c.836G>A; p.R279H; 2:218164376-218164376	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.858C>T; p.A286A; 2:218164354-218164354	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.255C>T; p.D85D; 2:218164957-218164957	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.516C>T; p.F172F; 2:218164696-218164696	skin	malignant_melanoma	Substitution - coding silent
c.854G>A; p.R285Q; 2:218164358-218164358	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.661T>A; p.C221S; 2:218164551-218164551	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.993G>A; p.L331L; 2:218164219-218164219	thyroid	other; neoplasm	Substitution - coding silent
c.259C>A; p.L87I; 2:218164953-218164953	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.838C>T; p.R280C; 2:218164374-218164374	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.838C>T; p.R280C; 2:218164374-218164374	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.575G>A; p.G192E; 2:218164637-218164637	skin	malignant_melanoma	Substitution - Missense
c.575G>A; p.G192E; 2:218164637-218164637	skin; mucosal	malignant_melanoma	Substitution - Missense
c.404G>A; p.R135H; 2:218164808-218164808	pancreas	carcinoma	Substitution - Missense
c.924C>T; p.I308I; 2:218164288-218164288	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.242T>A; p.L81Q; 2:218164970-218164970	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.239_241delACC; p.N80_L81>M; 2:218164971-218164973	lung	carcinoma; non_small_cell_carcinoma	Complex - deletion inframe
c.140C>T; p.A47V; 2:218165072-218165072	skin	malignant_melanoma	Substitution - Missense
c.642G>A; p.P214P; 2:218164570-218164570	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.642G>A; p.P214P; 2:218164570-218164570	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.957C>T; p.I319I; 2:218164255-218164255	skin	malignant_melanoma	Substitution - coding silent
c.839G>A; p.R280H; 2:218164373-218164373	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.345C>T; p.L115L; 2:218164867-218164867	skin	malignant_melanoma	Substitution - coding silent
c.816G>A; p.V272V; 2:218164396-218164396	skin	malignant_melanoma	Substitution - coding silent
c.522C>T; p.F174F; 2:218164690-218164690	skin	malignant_melanoma	Substitution - coding silent
c.440C>A; p.T147N; 2:218164772-218164772	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.212G>A; p.R71H; 2:218165000-218165000	pancreas	carcinoma	Substitution - Missense
c.212G>A; p.R71H; 2:218165000-218165000	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.636C>T; p.I212I; 2:218164576-218164576	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.636C>T; p.I212I; 2:218164576-218164576	skin	malignant_melanoma	Substitution - coding silent
c.482G>T; p.W161L; 2:218164730-218164730	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation