lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	27122
Symbol	DKK3
Synonymous	REIC\|RIG
Full name	dickkopf WNT signaling pathway inhibitor 3
Gene description	RIG-like 5-6\|RIG-like 7-1\|dickkopf 3 homolog\|dickkopf homolog 3\|dickkopf-3\|dickkopf-related protein 3\|dkk-3\|hDkk-3\|regulated in glioma
Cytoband	11p15.2
Gene type	protein-coding
Synonymous	MIM:605416; HGNC:HGNC:2893; Ensembl:ENSG00000050165; HPRD:05659; Vega:OTTHUMG00000165709

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.202G>A; p.A68T; 11:12008381-12008381	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.113T>A; p.L38H; 11:12008470-12008470	urinary_tract; bladder	carcinoma	Substitution - Missense
c.340G>A; p.E114K; 11:12002311-12002311	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.196C>T; p.R66C; 11:12008387-12008387	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.630C>A; p.N210K; 11:11966997-11966997	urinary_tract; bladder	carcinoma	Substitution - Missense
c.630C>A; p.N210K; 11:11966997-11966997	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.195G>A; p.L65L; 11:12008388-12008388	pancreas	carcinoma	Substitution - coding silent
c.698_699CC>TT; p.P233L; 11:11965940-11965941	skin	malignant_melanoma	Substitution - Missense
c.943G>A; p.E315K; 11:11964574-11964574	skin	malignant_melanoma	Substitution - Missense
c.278G>A; p.S93N; 11:12002373-12002373	breast	carcinoma	Substitution - Missense
c.514C>T; p.R172W; 11:11968409-11968409	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.875G>A; p.R292H; 11:11964642-11964642	skin	malignant_melanoma	Substitution - Missense
c.380T>A; p.V127D; 11:11998751-11998751	prostate	adenoma	Substitution - Missense
c.636G>A; p.R212R; 11:11966991-11966991	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.636G>A; p.R212R; 11:11966991-11966991	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.739C>T; p.R247W; 11:11965900-11965900	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.375A>G; p.Q125Q; 11:11998756-11998756	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.434A>T; p.H145L; 11:11998697-11998697	urinary_tract; bladder	carcinoma	Substitution - Missense
c.999G>A; p.A333A; 11:11964518-11964518	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.725A>C; p.H242P; 11:11965914-11965914	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.566T>A; p.L189Q; 11:11967061-11967061	breast	carcinoma	Substitution - Missense
c.839_840insT; p.V281fs*13; 11:11964677-11964678	breast	carcinoma	Insertion - Frameshift
c.183G>A; p.T61T; 11:12008400-12008400	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.439T>C; p.C147R; 11:11968484-11968484	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.386C>A; p.S129*; 11:11998745-11998745	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.795C>A; p.C265*; 11:11965844-11965844	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.258C>G; p.N86K; 11:12002393-12002393	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.258C>G; p.N86K; 11:12002393-12002393	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1003A>G; p.R335G; 11:11964514-11964514	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1003A>G; p.R335G; 11:11964514-11964514	thyroid	other; neoplasm	Substitution - Missense
c.958G>C; p.E320Q; 11:11964559-11964559	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.732C>T; p.P244P; 11:11965907-11965907	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.268T>C; p.L90L; 11:12002383-12002383	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.848T>A; p.V283E; 11:11964669-11964669	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.484G>T; p.A162S; 11:11968439-11968439	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.910G>C; p.V304L; 11:11964607-11964607	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.500C>T; p.T167I; 11:11968423-11968423	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.357C>G; p.T119T; 11:11998774-11998774	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.314G>C; p.G105A; 11:12002337-12002337	pancreas	carcinoma	Substitution - Missense
c.314G>C; p.G105A; 11:12002337-12002337	pancreas	carcinoma	Substitution - Missense
c.385T>C; p.S129P; 11:11998746-11998746	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1021G>T; p.A341S; 11:11964496-11964496	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.69C>A; p.P23P; 11:12008514-12008514	thyroid	other; neoplasm	Substitution - coding silent
c.936C>T; p.S312S; 11:11964581-11964581	liver	carcinoma	Substitution - coding silent
c.314G>A; p.G105E; 11:12002337-12002337	skin	malignant_melanoma	Substitution - Missense
c.543C>A; p.D181E; 11:11967084-11967084	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.543C>A; p.D181E; 11:11967084-11967084	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Missense
c.314G>A; p.G105E; 11:12002337-12002337	skin	malignant_melanoma	Substitution - Missense
c.894C>T; p.I298I; 11:11964623-11964623	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.667C>T; p.Q223*; 11:11966960-11966960	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.922T>C; p.Y308H; 11:11964595-11964595	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.953G>A; p.R318H; 11:11964564-11964564	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.953G>A; p.R318H; 11:11964564-11964564	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.515G>A; p.R172Q; 11:11968408-11968408	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.386C>G; p.S129*; 11:11998745-11998745	breast	carcinoma; ductal_carcinoma	Substitution - Nonsense
c.990A>G; p.E330E; 11:11964527-11964527	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.685C>T; p.P229S; 11:11965954-11965954	skin	malignant_melanoma	Substitution - Missense
c.1017_1018delTG; p.A340fs*>11; 11:11964499-11964500	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.1017_1018delTG; p.A340fs*>11; 11:11964499-11964500	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.171G>A; p.L57L; 11:12008412-12008412	skin	malignant_melanoma	Substitution - coding silent
c.158A>G; p.E53G; 11:12008425-12008425	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1009C>T; p.P337S; 11:11964508-11964508	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.711G>A; p.E237E; 11:11965928-11965928	skin	malignant_melanoma	Substitution - coding silent
c.704C>T; p.P235L; 11:11965935-11965935	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.182C>T; p.T61M; 11:12008401-12008401	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1034T>C; p.L345P; 11:11964483-11964483	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.340G>T; p.E114*; 11:12002311-12002311	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.835A>G; p.S279G; 11:11964682-11964682	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.381C>G; p.V127V; 11:11998750-11998750	breast	carcinoma	Substitution - coding silent
c.673+2T>C; p.?; 11:11966952-11966952	stomach	carcinoma; intestinal_adenocarcinoma	Unknown

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation